{"id":"https://openalex.org/W613396043","doi":"https://doi.org/10.1038/srep10856","title":"KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage","display_name":"KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage","publication_year":2015,"publication_date":"2015-06-03","ids":{"openalex":"https://openalex.org/W613396043","doi":"https://doi.org/10.1038/srep10856","mag":"613396043","pmid":"https://pubmed.ncbi.nlm.nih.gov/26039276","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4454167"},"language":"en","primary_location":{"id":"doi:10.1038/srep10856","doi":"https://doi.org/10.1038/srep10856","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep10856","pdf_url":"https://www.nature.com/articles/srep10856.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep10856.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111373536","display_name":"Eun-Yeung Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eun-Yeung Gong","raw_affiliation_strings":["Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K","institution_ids":["https://openalex.org/I4210143228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047402317","display_name":"Veronique A. J. Smits","orcid":"https://orcid.org/0000-0002-9160-4525","observed_orcids":["https://orcid.org/0000-0002-9160-4525"]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Veronique A. J. Smits","raw_affiliation_strings":["Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna 38320, Tenerife, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna 38320, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084413170","display_name":"Felipe Fumagallo-Reading","orcid":"https://orcid.org/0000-0001-6682-6612","observed_orcids":["https://orcid.org/0000-0001-6682-6612"]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Felipe Fumagallo","raw_affiliation_strings":["Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna 38320, Tenerife, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna 38320, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071280015","display_name":"Desir\u00e8e Piscitello","orcid":"https://orcid.org/0000-0002-2510-4717","observed_orcids":["https://orcid.org/0000-0002-2510-4717"]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Desiree Piscitello","raw_affiliation_strings":["Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K","institution_ids":["https://openalex.org/I4210143228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028009861","display_name":"Nick A. MORRICE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Morrice","raw_affiliation_strings":["Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K","institution_ids":["https://openalex.org/I4210143228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083487166","display_name":"Raimundo Freire","orcid":"https://orcid.org/0000-0003-4473-8894","observed_orcids":["https://orcid.org/0000-0003-4473-8894"]},"institutions":[{"id":"https://openalex.org/I2800401438","display_name":"Hospital Universitario de Canarias","ror":"https://ror.org/05qndj312","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800401438"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raimundo Freire","raw_affiliation_strings":["Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna 38320, Tenerife, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna 38320, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario de Canarias, Instituto de Tecnolog\u00edas Biom\u00e9dicas, Ofra s/n, La Cuesta, La Laguna, Tenerife, Spain","institution_ids":["https://openalex.org/I2800401438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055844538","display_name":"David A. Gillespie","orcid":"https://orcid.org/0000-0002-6338-0544","observed_orcids":["https://orcid.org/0000-0002-6338-0544"]},"institutions":[{"id":"https://openalex.org/I158438070","display_name":"Universidad de La Laguna","ror":"https://ror.org/01r9z8p25","country_code":"ES","type":"education","lineage":["https://openalex.org/I158438070"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"David A. Gillespie","raw_affiliation_strings":["Instituto de Tecnolog\u00edas Biom\u00e9dicas, Centro de Investigaciones Biom\u00e9dicas de Canarias, Facultad de Medicina, Campus Ciencias de la Salud, Universidad de La Laguna, La Laguna 38071, Tenerife, Spain","Instituto de Tecnolog\u00edas Biom\u00e9dicas, Centro de Investigaciones Biom\u00e9dicas de Canarias, Facultad de Medicina, Campus Ciencias de la Salud, Universidad de La Laguna, La Laguna, Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Centro de Investigaciones Biom\u00e9dicas de Canarias, Facultad de Medicina, Campus Ciencias de la Salud, Universidad de La Laguna, La Laguna 38071, Tenerife, Spain","institution_ids":["https://openalex.org/I158438070"]},{"raw_affiliation_string":"Instituto de Tecnolog\u00edas Biom\u00e9dicas, Centro de Investigaciones Biom\u00e9dicas de Canarias, Facultad de Medicina, Campus Ciencias de la Salud, Universidad de La Laguna, La Laguna, Tenerife, Spain","institution_ids":["https://openalex.org/I158438070"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055844538"],"corresponding_institution_ids":["https://openalex.org/I158438070"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.923,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.70563824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"10856","last_page":"10856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-terminal-regulatory-domain","display_name":"C-terminal regulatory domain","score":0.8009999990463257},{"id":"https://openalex.org/keywords/constitutive-kinase-activity","display_name":"constitutive kinase activity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/g2-cell-cycle-arrest","display_name":"G2 cell cycle arrest","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protein-kinase-structure","display_name":"protein kinase structure","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6849361062049866},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6654190421104431},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6052267551422119},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5833041667938232},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.5818143486976624},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5759197473526001},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.568318247795105},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5407398343086243},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.5305811762809753},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5135317444801331},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.44602835178375244},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.43529611825942993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4030631184577942},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3642246425151825},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3408157229423523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3373376131057739},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.29701992869377136},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.20399045944213867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19249114394187927}],"mesh":[{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020664","descriptor_name":"Son of Sevenless Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020664","descriptor_name":"Son of Sevenless Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020664","descriptor_name":"Son of Sevenless Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059565","descriptor_name":"G2 Phase Cell Cycle Checkpoints","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep10856","doi":"https://doi.org/10.1038/srep10856","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep10856","pdf_url":"https://www.nature.com/articles/srep10856.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:26039276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26039276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4454167","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4454167/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:eprints.gla.ac.uk:107643","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/view/author/31533.html>,","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Articles"}],"best_oa_location":{"id":"doi:10.1038/srep10856","doi":"https://doi.org/10.1038/srep10856","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep10856","pdf_url":"https://www.nature.com/articles/srep10856.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2853181987","display_name":null,"funder_award_id":"FP7-REGPOT-2012-CT2012-31637-IMBRAIN","funder_id":"https://openalex.org/F4320338351","funder_display_name":"FP7 Research Potential of Convergence Regions"},{"id":"https://openalex.org/G4314142598","display_name":null,"funder_award_id":"31637","funder_id":"https://openalex.org/F4320338351","funder_display_name":"FP7 Research Potential of Convergence Regions"},{"id":"https://openalex.org/G6518970744","display_name":null,"funder_award_id":"22311","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320338351","display_name":"FP7 Research Potential of Convergence Regions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W613396043.pdf","grobid_xml":"https://content.openalex.org/works/W613396043.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1553367038","https://openalex.org/W1994909028","https://openalex.org/W1995815026","https://openalex.org/W2004228538","https://openalex.org/W2008477400","https://openalex.org/W2012677683","https://openalex.org/W2020347983","https://openalex.org/W2023860520","https://openalex.org/W2033497590","https://openalex.org/W2034570201","https://openalex.org/W2041185002","https://openalex.org/W2045305010","https://openalex.org/W2047806985","https://openalex.org/W2059182662","https://openalex.org/W2076314401","https://openalex.org/W2086038348","https://openalex.org/W2092499625","https://openalex.org/W2092904031","https://openalex.org/W2095027692","https://openalex.org/W2097404112","https://openalex.org/W2105592350","https://openalex.org/W2110429847","https://openalex.org/W2111403239","https://openalex.org/W2112190173","https://openalex.org/W2115020362","https://openalex.org/W2117273743","https://openalex.org/W2117314668","https://openalex.org/W2118266991","https://openalex.org/W2123955384","https://openalex.org/W2134547388","https://openalex.org/W2146741358","https://openalex.org/W2150857270","https://openalex.org/W2151180466","https://openalex.org/W2172106590"],"related_works":["https://openalex.org/W2008477400","https://openalex.org/W2042883687","https://openalex.org/W2034570201","https://openalex.org/W2023860520","https://openalex.org/W2246803876","https://openalex.org/W2059182662","https://openalex.org/W1969431807","https://openalex.org/W3149286975","https://openalex.org/W2086038348","https://openalex.org/W2763372195"],"abstract_inverted_index":{"The":[0],"Chk1":[1,40,66,82,145],"protein":[2,50,55],"kinase":[3,116],"is":[4,28,120,137],"activated":[5],"in":[6,53,90,99],"response":[7],"to":[8,68,124],"DNA":[9,94],"damage":[10],"through":[11],"ATR-mediated":[12,157],"phosphorylation":[13,127],"at":[14],"multiple":[15,54],"serine-glutamine":[16],"(SQ)":[17],"residues":[18],"within":[19],"the":[20,25,74,91,103,129,143,154],"C-terminal":[21],"regulatory":[22,132,159],"domain,":[23,46],"however":[24,126],"molecular":[26],"mechanism":[27],"not":[29,138],"understood.":[30],"Modelling":[31],"indicates":[32],"a":[33,42,47],"high":[34],"probability":[35],"that":[36],"this":[37],"region":[38],"of":[39,73,80,93,102,128],"contains":[41],"kinase-associated":[43],"1":[44],"(KA1)":[45],"small,":[48],"compact":[49],"fold":[51],"found":[52],"kinases":[56],"including":[57],"SOS2,":[58],"AMPK":[59],"and":[60],"MARK3.":[61],"We":[62],"introduced":[63],"mutations":[64,141],"into":[65],"designed":[67],"disrupt":[69],"specific":[70],"structural":[71],"elements":[72],"predicted":[75],"KA1":[76,83,146],"domain.":[77],"Remarkably,":[78],"six":[79],"seven":[81],"mutants":[84,113],"exhibit":[85],"constitutive":[86,149],"biological":[87,150],"activity":[88,151],"(Chk1-CA)":[89],"absence":[92],"damage,":[95],"profoundly":[96],"arresting":[97],"cells":[98],"G2":[100],"phase":[101],"cell":[104],"cycle.":[105],"Cell":[106],"cycle":[107],"arrest":[108],"induced":[109],"by":[110,152],"selected":[111],"Chk1-CA":[112],"depends":[114],"on":[115],"catalytic":[117],"activity,":[118],"which":[119],"increased":[121],"several-fold":[122],"compared":[123],"wild-type,":[125],"key":[130],"ATR":[131],"site":[133],"serine":[134],"345":[135],"(S345)":[136],"required.":[139],"Thus,":[140],"targeting":[142],"putative":[144],"domain":[147],"confer":[148],"circumventing":[153],"need":[155],"for":[156],"positive":[158],"phosphorylation.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}