{"id":"https://openalex.org/W612142883","doi":"https://doi.org/10.1016/j.neuropharm.2015.05.023","title":"Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice","display_name":"Effects of orally-bioavailable short-acting kappa opioid receptor-selective antagonist LY2456302 on nicotine withdrawal in mice","publication_year":2015,"publication_date":"2015-06-04","ids":{"openalex":"https://openalex.org/W612142883","doi":"https://doi.org/10.1016/j.neuropharm.2015.05.023","mag":"612142883","pmid":"https://pubmed.ncbi.nlm.nih.gov/26044637","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4537361"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuropharm.2015.05.023","doi":"https://doi.org/10.1016/j.neuropharm.2015.05.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2015.05.023","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4537361","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081095090","display_name":"Kia J. Jackson","orcid":"https://orcid.org/0000-0002-3913-8774","observed_orcids":["https://orcid.org/0000-0002-3913-8774"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kia J. Jackson","raw_affiliation_strings":["Department of Psychiatry, Virginia Commonwealth University, 800 E. Leigh St., Suite 390A, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Virginia Commonwealth University, 800 E. Leigh St., Suite 390A, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078284278","display_name":"Asti B. Jackson","orcid":"https://orcid.org/0000-0002-0263-7262","observed_orcids":["https://orcid.org/0000-0002-0263-7262"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asti Jackson","raw_affiliation_strings":["Department of Pharmacology/Toxicology, Virginia Commonwealth University, 1220 E. Broad St., MMRB, Box 980613, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology/Toxicology, Virginia Commonwealth University, 1220 E. Broad St., MMRB, Box 980613, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112366469","display_name":"Frank Ivy Carroll","orcid":"https://orcid.org/0000-0001-9510-765X","observed_orcids":["https://orcid.org/0000-0001-9510-765X"]},"institutions":[{"id":"https://openalex.org/I180297670","display_name":"RTI International","ror":"https://ror.org/052tfza37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Ivy Carroll","raw_affiliation_strings":["Research Triangle Institute, Research Triangle Park, NC, USA","[Res. Triangle Inst., Research Triangle Park, NC, USA]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Triangle Institute, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I180297670"]},{"raw_affiliation_string":"[Res. Triangle Inst., Research Triangle Park, NC, USA]","institution_ids":["https://openalex.org/I180297670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036036065","display_name":"Mohamad Imad Damaj","orcid":"https://orcid.org/0000-0002-8859-029X","observed_orcids":["https://orcid.org/0000-0002-8859-029X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Imad Damaj","raw_affiliation_strings":["Department of Pharmacology/Toxicology, Virginia Commonwealth University, 1220 E. Broad St., MMRB, Box 980613, Richmond, VA 23219, USA. Electronic address: mdamaj@vcu.edu","Department of Pharmacology/Toxicology, Virginia Commonwealth University, 1220 E. Broad St., MMRB, Box 980613, Richmond, VA 23219, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology/Toxicology, Virginia Commonwealth University, 1220 E. Broad St., MMRB, Box 980613, Richmond, VA 23219, USA. Electronic address: mdamaj@vcu.edu","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Pharmacology/Toxicology, Virginia Commonwealth University, 1220 E. Broad St., MMRB, Box 980613, Richmond, VA 23219, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036036065"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":null,"fwci":1.7996,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.82214822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"97","issue":null,"first_page":"270","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kappa-opioid-receptor-antagonist","display_name":"kappa opioid receptor antagonists","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nicotine-withdrawal","display_name":"nicotine withdrawal","score":0.953000009059906},{"id":"https://openalex.org/keywords/nicotine-dependence","display_name":"nicotine dependence","score":0.621999979019165},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.6980000138282776},{"id":"https://openalex.org/keywords/conditioned-place-aversion","display_name":"conditioned place aversion","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nor-binaltorphimine","display_name":"nor-binaltorphimine","score":0.847000002861023},{"id":"https://openalex.org/keywords/jdtic","display_name":"JDTic","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.460999995470047},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.8205037117004395},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6669842004776001},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6229444146156311},{"id":"https://openalex.org/C2779177420","wikidata":"https://www.wikidata.org/wiki/Q3961638","display_name":"Nicotine withdrawal","level":3,"score":0.4966474175453186},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.41956087946891785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4127044379711151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3157813251018524},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2473827302455902},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.2368660271167755}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013037","descriptor_name":"Spatial Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013037","descriptor_name":"Spatial Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014029","descriptor_name":"Tobacco Use Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014029","descriptor_name":"Tobacco Use Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuropharm.2015.05.023","doi":"https://doi.org/10.1016/j.neuropharm.2015.05.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2015.05.023","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:26044637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26044637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3998052","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4537361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4537361","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4537361","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuropharmacology","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3998052","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4537361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4424055690","display_name":"Monoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders","funder_award_id":"R01DA032933","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4647910996","display_name":"Genes and molecular pathways in nicotine dependence and withdrawal","funder_award_id":"R01DA032246","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6673034537","display_name":null,"funder_award_id":"N01DA-12-8904","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W155846689","https://openalex.org/W1490652616","https://openalex.org/W1508965698","https://openalex.org/W1963557453","https://openalex.org/W1965573444","https://openalex.org/W1981629237","https://openalex.org/W1990309411","https://openalex.org/W1992950273","https://openalex.org/W2010158373","https://openalex.org/W2010222907","https://openalex.org/W2010455608","https://openalex.org/W2012738237","https://openalex.org/W2016371102","https://openalex.org/W2023924110","https://openalex.org/W2024063816","https://openalex.org/W2024791543","https://openalex.org/W2039689448","https://openalex.org/W2040931588","https://openalex.org/W2043184629","https://openalex.org/W2052443455","https://openalex.org/W2053472601","https://openalex.org/W2054092950","https://openalex.org/W2054388960","https://openalex.org/W2055686857","https://openalex.org/W2066848874","https://openalex.org/W2073674800","https://openalex.org/W2085217701","https://openalex.org/W2085473545","https://openalex.org/W2093282262","https://openalex.org/W2096891361","https://openalex.org/W2102502501","https://openalex.org/W2112994833","https://openalex.org/W2123802262","https://openalex.org/W2132736053","https://openalex.org/W2147360737","https://openalex.org/W2159202946","https://openalex.org/W2162992969","https://openalex.org/W4322696862"],"related_works":["https://openalex.org/W1992950273","https://openalex.org/W4321004482","https://openalex.org/W2010222907","https://openalex.org/W2093282262","https://openalex.org/W2016371102","https://openalex.org/W2085473545","https://openalex.org/W3103250094","https://openalex.org/W4384493121","https://openalex.org/W4242998058","https://openalex.org/W1983271098"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}