{"id":"https://openalex.org/W611900406","doi":null,"title":"Role of Cell-cell Interactions and Palmitate on \u03b2-cells Function","display_name":"Role of Cell-cell Interactions and Palmitate on \u03b2-cells Function","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W611900406","mag":"611900406"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-230841","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230841","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230841","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078647024","display_name":"Azazul Islam Chowdhury","orcid":"https://orcid.org/0000-0002-9022-714X","observed_orcids":["https://orcid.org/0000-0002-9022-714X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Azazul Chowdhury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078647024"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.9039999842643738},{"id":"https://openalex.org/keywords/palmitate","display_name":"palmitate","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pseudoislets","display_name":"pseudoislets","score":0.8510000109672546},{"id":"https://openalex.org/keywords/min6-cells","display_name":"MIN6 cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9580000042915344},{"id":"https://openalex.org/keywords/socs2","display_name":"SOCS2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pias1","display_name":"PIAS1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.6830000281333923},{"id":"https://openalex.org/keywords/acetyl-coa","display_name":"acetyl-CoA","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8130000233650208},{"id":"https://openalex.org/keywords/islet-dysfunction","display_name":"islet dysfunction","score":0.718999981880188},{"id":"https://openalex.org/keywords/saturated-free-fatty-acids","display_name":"saturated free fatty acids","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.709364116191864},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6110329627990723},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5783379077911377},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.543718695640564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5034355521202087},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.46090659499168396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44038230180740356},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43160852789878845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41185060143470764},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27094095945358276},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.1917388141155243},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16695654392242432},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07978549599647522}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-230841","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230841","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:611900406","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A742080","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-230841","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230841","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":173,"referenced_works":["https://openalex.org/W176352299","https://openalex.org/W1488478985","https://openalex.org/W1499384204","https://openalex.org/W1567146796","https://openalex.org/W1572077460","https://openalex.org/W1583798678","https://openalex.org/W1602234554","https://openalex.org/W1612279088","https://openalex.org/W1661605701","https://openalex.org/W1668039320","https://openalex.org/W1827691446","https://openalex.org/W1934809504","https://openalex.org/W1944558458","https://openalex.org/W1945252427","https://openalex.org/W1964466523","https://openalex.org/W1964832108","https://openalex.org/W1965549524","https://openalex.org/W1967286688","https://openalex.org/W1970193357","https://openalex.org/W1970398807","https://openalex.org/W1970925130","https://openalex.org/W1971413372","https://openalex.org/W1971713572","https://openalex.org/W1972051140","https://openalex.org/W1972114957","https://openalex.org/W1973837499","https://openalex.org/W1974408786","https://openalex.org/W1974842079","https://openalex.org/W1977858765","https://openalex.org/W1978883490","https://openalex.org/W1981747327","https://openalex.org/W1985149672","https://openalex.org/W1985386582","https://openalex.org/W1985599023","https://openalex.org/W1985723042","https://openalex.org/W1987417071","https://openalex.org/W1987840126","https://openalex.org/W1990865579","https://openalex.org/W1991697379","https://openalex.org/W1992002046","https://openalex.org/W1993520606","https://openalex.org/W1993847893","https://openalex.org/W1995802547","https://openalex.org/W1998002161","https://openalex.org/W2001145569","https://openalex.org/W2001252698","https://openalex.org/W2004140559","https://openalex.org/W2006062639","https://openalex.org/W2007653885","https://openalex.org/W2010993435","https://openalex.org/W2012260744","https://openalex.org/W2014032285","https://openalex.org/W2014887370","https://openalex.org/W2015038984","https://openalex.org/W2019133751","https://openalex.org/W2019283908","https://openalex.org/W2020110583","https://openalex.org/W2021925516","https://openalex.org/W2021961757","https://openalex.org/W2022228039","https://openalex.org/W2022915573","https://openalex.org/W2024851295","https://openalex.org/W2025143098","https://openalex.org/W2025202899","https://openalex.org/W2025890197","https://openalex.org/W2031652675","https://openalex.org/W2032175501","https://openalex.org/W2032255728","https://openalex.org/W2036848107","https://openalex.org/W2037802736","https://openalex.org/W2040595653","https://openalex.org/W2041129796","https://openalex.org/W2042621509","https://openalex.org/W2044191529","https://openalex.org/W2044437167","https://openalex.org/W2045312491","https://openalex.org/W2049372068","https://openalex.org/W2049564955","https://openalex.org/W2050720508","https://openalex.org/W2052311839","https://openalex.org/W2052964822","https://openalex.org/W2056784230","https://openalex.org/W2058194924","https://openalex.org/W2061952617","https://openalex.org/W2065351763","https://openalex.org/W2069570437","https://openalex.org/W2069711307","https://openalex.org/W2069730743","https://openalex.org/W2069895399","https://openalex.org/W2070319873","https://openalex.org/W2071546758","https://openalex.org/W2071918897","https://openalex.org/W2074528335","https://openalex.org/W2076686883","https://openalex.org/W2077399654","https://openalex.org/W2078594804","https://openalex.org/W2079508317","https://openalex.org/W2083227753","https://openalex.org/W2085901707","https://openalex.org/W2088430561","https://openalex.org/W2089865773","https://openalex.org/W2090038705","https://openalex.org/W2091389339","https://openalex.org/W2091758912","https://openalex.org/W2093090129","https://openalex.org/W2095252238","https://openalex.org/W2096663326","https://openalex.org/W2096679913","https://openalex.org/W2102964449","https://openalex.org/W2103174300","https://openalex.org/W2105497606","https://openalex.org/W2106437575","https://openalex.org/W2106794670","https://openalex.org/W2109216839","https://openalex.org/W2113307670","https://openalex.org/W2114580401","https://openalex.org/W2117074858","https://openalex.org/W2117327695","https://openalex.org/W2117637410","https://openalex.org/W2117716503","https://openalex.org/W2119553344","https://openalex.org/W2119596771","https://openalex.org/W2119702318","https://openalex.org/W2120163083","https://openalex.org/W2121338998","https://openalex.org/W2121428233","https://openalex.org/W2122568821","https://openalex.org/W2124360636","https://openalex.org/W2124971376","https://openalex.org/W2126393987","https://openalex.org/W2126610675","https://openalex.org/W2128326754","https://openalex.org/W2133162233","https://openalex.org/W2134646045","https://openalex.org/W2136454890","https://openalex.org/W2137976281","https://openalex.org/W2140188411","https://openalex.org/W2140300073","https://openalex.org/W2140793658","https://openalex.org/W2141431389","https://openalex.org/W2144579086","https://openalex.org/W2144803025","https://openalex.org/W2145855884","https://openalex.org/W2145937373","https://openalex.org/W2146157811","https://openalex.org/W2146272458","https://openalex.org/W2146460118","https://openalex.org/W2146544786","https://openalex.org/W2148175667","https://openalex.org/W2149227688","https://openalex.org/W2150019992","https://openalex.org/W2151570019","https://openalex.org/W2151706465","https://openalex.org/W2152000177","https://openalex.org/W2152429535","https://openalex.org/W2153599475","https://openalex.org/W2153673003","https://openalex.org/W2156460405","https://openalex.org/W2157627155","https://openalex.org/W2158788992","https://openalex.org/W2161144814","https://openalex.org/W2161834501","https://openalex.org/W2162887701","https://openalex.org/W2163323666","https://openalex.org/W2163406329","https://openalex.org/W2165047972","https://openalex.org/W2166998713","https://openalex.org/W2176847545","https://openalex.org/W2323026271","https://openalex.org/W2404711019","https://openalex.org/W4234663921","https://openalex.org/W4240412720","https://openalex.org/W4241091589"],"related_works":["https://openalex.org/W2156460405","https://openalex.org/W2228066206","https://openalex.org/W1999240103","https://openalex.org/W4315645202","https://openalex.org/W7099984330","https://openalex.org/W2061421745","https://openalex.org/W2913438530","https://openalex.org/W649708299","https://openalex.org/W2160154061","https://openalex.org/W2154238184"],"abstract_inverted_index":{"The":[0,53],"islets":[1,24,175],"of":[2,10,27,32,43,55,63,75,103,148,170,192,194,201,206,210,220,244],"Langerhans":[3],"secrets":[4],"insulin":[5,92,185],"in":[6,30,37,96,113,141,178],"response":[7],"to":[8,50,59,99,132,151],"fluctuations":[9],"blood":[11],"glucose":[12,108],"level":[13,219],"and":[14,40,66,87,136,162,198,225,246],"efficient":[15],"secretion":[16,93,186],"requires":[17],"extensive":[18],"intra-islet":[19],"communication.":[20],"Secretory":[21],"failure":[22],"from":[23],"is":[25,58,188],"one":[26],"the":[28,61,73,145,168],"hallmark":[29],"progression":[31],"type":[33],"2":[34],"diabetes.":[35],"Changes":[36],"islet":[38],"structure":[39],"high":[41],"levels":[42,102,130],"saturated":[44],"free":[45],"fatty":[46],"acids":[47],"may":[48,251],"contribute":[49],"this":[51,56],"failure.":[52],"aim":[54],"thesis":[57],"study":[60],"role":[62,74,169],"cell-cell":[64,76],"interactions":[65,77],"palmitate":[67,171,182,235],"on":[68,78,154,172],"\u03b2-cells":[69,79,173,253],"functions.":[70],"To":[71,166],"address":[72,167],"functions":[80],"MIN6":[81],"cells":[82,123],"were":[83,124,139,176],"cultured":[84,177],"as":[85,88,106,126],"monolayers":[86,152],"pseudoislets.":[89,114,127,142],"Glucose":[90],"stimulated":[91],"was":[94,111,120],"higher":[95,112],"pseudoislets":[97,149],"compared":[98,150],"monolayers.":[100],"Transcript":[101],"mitochondrial":[104],"metabolism":[105],"well":[107],"oxidation":[109],"rate":[110],"Insulin":[115],"receptor":[116],"substrate-1":[117],"(IRS-1)":[118],"phosphorylation":[119,209],"altered":[121],"when":[122],"grown":[125],"Proteins":[128],"expression":[129],"related":[131],"glycolysis,":[133],"cellular":[134],"connections":[135],"translational":[137],"regulations":[138],"up-regulated":[140],"We":[143,231],"propose":[144,232],"superior":[146],"capacity":[147],"depend":[153],"metabolism,":[155],"cell":[156],"coupling,":[157],"gene":[158],"translation,":[159],"protein":[160,199,218],"turnover":[161],"differential":[163],"IRS-1":[164],"phosphorylation.":[165],"human":[174],"palmitate.":[179],"Long":[180],"term":[181,234],"treatment":[183,236],"decreased":[184,208,217],"which":[187,250],"associated":[189],"with":[190],"up-regulation":[191],"suppressor":[193],"cytokine":[195],"signaling-2":[196],"(SOCS2)":[197],"inhibitor":[200],"activated":[202],"STAT-1":[203],"(PIAS1).":[204],"Up-regulation":[205],"SOCS2":[207],"Akt":[211],"at":[212],"site":[213],"T308,":[214],"whereas":[215],"PIAS1":[216],"ATP-":[221],"citrate":[222],"lyase":[223],"(ACLY)":[224],"ATP":[226,248],"synthase":[227],"subunit":[228],"B":[229],"(ATP5B).":[230],"long":[233],"reduces":[237],"phosphatidylinositol":[238],"3-kinase":[239],"(PI3K)":[240],"activity,":[241],"attenuates":[242],"formation":[243],"acetyl-CoA":[245],"decreases":[247],"synthesis":[249],"aggravate":[252],"dysfunction.":[254]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}