{"id":"https://openalex.org/W61189259","doi":null,"title":"Chrono-neuroendocrinological aspects of physiological aging and senile dementia.","display_name":"Chrono-neuroendocrinological aspects of physiological aging and senile dementia.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W61189259","mag":"61189259","pmid":"https://pubmed.ncbi.nlm.nih.gov/7924632"},"language":"en","primary_location":{"id":"pmid:7924632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7924632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chronobiologia","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083967896","display_name":"D. Dori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Dori","raw_affiliation_strings":["Dipartimento di Medicina Interna e Terapia Medica, Universit\u00e0 di Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Terapia Medica, Universit\u00e0 di Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112740803","display_name":"G Casale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Casale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074382189","display_name":"Sebastiano Bruno Solerte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S B Solerte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049812298","display_name":"Mario Fioravanti","orcid":"https://orcid.org/0000-0002-3707-3081","observed_orcids":["https://orcid.org/0000-0002-3707-3081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Fioravanti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089806100","display_name":"Giuseppe Migliorati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Migliorati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108518810","display_name":"Gianni Cuzzoni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Cuzzoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103229026","display_name":"Elena Ferrari","orcid":"https://orcid.org/0000-0003-3273-7173","observed_orcids":["https://orcid.org/0000-0003-3273-7173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Ferrari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6201,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.56481836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":"1-2","first_page":"121","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.7202000021934509,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.22509999573230743,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senile-dementia","display_name":"senile dementia","score":0.7990000247955322},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/multi-infarct-dementia","display_name":"multi-infarct dementia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.699999988079071},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.953000009059906},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9120000004768372},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dexamethasone-suppression-test","display_name":"dexamethasone suppression test","score":0.972000002861023},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.7670000195503235},{"id":"https://openalex.org/keywords/neuroendocrinology","display_name":"neuroendocrinology","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8247148990631104},{"id":"https://openalex.org/C2776476923","wikidata":"https://www.wikidata.org/wiki/Q7725","display_name":"Evening","level":2,"score":0.7766096591949463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7108496427536011},{"id":"https://openalex.org/C2780455818","wikidata":"https://www.wikidata.org/wiki/Q1207196","display_name":"Dexamethasone suppression test","level":3,"score":0.6496469974517822},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6339278221130371},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.6218829154968262},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5487438440322876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.539426326751709},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.4761671721935272},{"id":"https://openalex.org/C2777334680","wikidata":"https://www.wikidata.org/wiki/Q1607611","display_name":"Nocturnal","level":2,"score":0.4497976005077362},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4329685568809509},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42510196566581726},{"id":"https://openalex.org/C2993097608","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Senile dementia","level":4,"score":0.41644272208213806},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.28588414192199707},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10405924916267395},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7924632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7924632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chronobiologia","raw_type":"Clinical Trial"},{"id":"mag:61189259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7924632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2036931212","https://openalex.org/W2049560229","https://openalex.org/W2043982245","https://openalex.org/W2049358643","https://openalex.org/W1993246378","https://openalex.org/W2164865501","https://openalex.org/W2163998633","https://openalex.org/W2116341786","https://openalex.org/W2072612731","https://openalex.org/W2015776877"],"abstract_inverted_index":{"The":[0],"circadian":[1,103,117],"pattern":[2],"of":[3,13,23,62,112,126,139,181,187,227,231],"melatonin":[4,100,116,140],"and":[5,29,77,88,101,166,177,208,240,253],"cortisol":[6,102,153,221],"secretion":[7],"was":[8,119,201,237],"evaluated":[9],"in":[10,108,122,149,204,210,243,248,254],"two":[11,124],"groups":[12,111,125],"elderly":[14,127,145,206],"subjects":[15,128,252],"(aged":[16],"66-90":[17],"years),":[18],"one":[19],"with":[20,81,131,216],"Alzheimer's":[21],"type":[22],"multiinfarct":[24],"dementia":[25],"(n":[26,35],"=":[27,36],"27)":[28],"the":[30,63,92,109,115,123,136,174,178,185,188],"other":[31],"without":[32],"cognitive":[33],"impairment":[34,138],"16);":[37],"13":[38],"clinically":[39],"healthy":[40,250],"women":[41],"aged":[42],"20":[43],"to":[44,59,83,135,160,191,223],"30":[45],"years":[46],"were":[47,73,78,155],"chosen":[48],"as":[49,75],"controls.":[50,218],"All":[51,67],"demented":[52,150,212,245],"patients":[53,246],"had":[54],"severe":[55],"mental":[56],"impairment,":[57],"corresponding":[58],"stage":[60],"6":[61],"Global":[64],"Deterioration":[65],"Scale.":[66],"subjects,":[68],"either":[69],"young":[70,132,161,217,255],"or":[71],"aged,":[72],"studied":[74],"in-patients":[76],"well":[79],"synchronized":[80],"respect":[82],"meal":[84],"timing,":[85],"diurnal":[86],"activity":[87],"nocturnal":[89,141],"rest.":[90],"At":[91],"population":[93],"mean":[94],"cosinor":[95],"analysis":[96],"(Halberg,":[97],"1969)":[98],"both":[99,144,205],"rhythms":[104],"reached":[105],"statistical":[106],"significance":[107],"three":[110],"subjects.":[113],"However,":[114],"profile":[118],"clearly":[120],"flattened":[121],"by":[129,158,214],"comparison":[130,159,215],"controls,":[133,162],"due":[134],"selective":[137],"secretion.":[142],"In":[143],"groups,":[146,207],"but":[147],"particularly":[148,163],"patients,":[151,213],"plasma":[152,182,220],"levels":[154],"significantly":[156,202,238],"higher":[157,239],"at":[164,199],"evening":[165],"night":[167],"time.":[168],"A":[169],"significant":[170],"direct":[171],"relationship":[172],"linked":[173],"subjects'":[175],"age":[176],"nadir":[179],"values":[180],"cortisol.":[183],"Furthermore,":[184],"sensitivity":[186],"hypothalamo-pituitary-adrenal":[189],"axis":[190],"dexamethasone":[192],"(DXM)":[193],"suppression":[194],"test":[195],"(1":[196],"mg":[197],"orally":[198],"2300)":[200],"reduced":[203],"especially":[209],"old":[211,244,251],"Finally,":[219],"response":[222],"pulse":[224],"i.v.":[225],"injection":[226],"a":[228],"small":[229],"dose":[230],"synthetic":[232],"corticotropin":[233],"(Synacthen":[234],"2,500":[235],"ng)":[236],"more":[241],"prolonged":[242],"than":[247],"mentally":[249],"controls.(ABSTRACT":[256],"TRUNCATED":[257],"AT":[258],"250":[259],"WORDS)":[260]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}