{"id":"https://openalex.org/W610485274","doi":null,"title":"Attenuation of morphine tolerance and dependence by thymoquinone in mice.","display_name":"Attenuation of morphine tolerance and dependence by thymoquinone in mice.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W610485274","mag":"610485274","pmid":"https://pubmed.ncbi.nlm.nih.gov/27247922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4884218"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4884218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4884218/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4884218/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna J Phytomed","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4884218/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015123190","display_name":"Hossein Hosseinzadeh","orcid":"https://orcid.org/0000-0002-3483-851X","observed_orcids":["https://orcid.org/0000-0002-3483-851X","https://orcid.org/0000-0002-7755-2204"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Hosseinzadeh","raw_affiliation_strings":["Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069854860","display_name":"Siavash Parvardeh","orcid":"https://orcid.org/0000-0002-5001-4633","observed_orcids":["https://orcid.org/0000-0002-5001-4633"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Siavash Parvardeh","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022609461","display_name":"Alireza Masoudi","orcid":"https://orcid.org/0000-0002-5598-9384","observed_orcids":["https://orcid.org/0000-0002-5598-9384"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Alireza Masoudi","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051391749","display_name":"Mahsa Moghimi","orcid":"https://orcid.org/0000-0003-3387-9560","observed_orcids":["https://orcid.org/0000-0003-3387-9560"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahsa Moghimi","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074250021","display_name":"Fatemeh Mahboobifard","orcid":"https://orcid.org/0000-0002-0259-0994","observed_orcids":["https://orcid.org/0000-0002-0259-0994"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Mahboobifard","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0898,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.94124824,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"55","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12750","display_name":"Nigella sativa pharmacological applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymoquinone","display_name":"thymoquinone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/morphine-tolerance","display_name":"morphine tolerance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/morphine-dependence","display_name":"morphine dependence","score":0.9879999756813049},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nigella-sativa","display_name":"Nigella sativa","score":0.9649999737739563},{"id":"https://openalex.org/keywords/naloxone-precipitated-withdrawal","display_name":"naloxone-precipitated withdrawal","score":0.8180000185966492},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8769999742507935},{"id":"https://openalex.org/keywords/motor-coordination","display_name":"motor coordination","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2779034068","wikidata":"https://www.wikidata.org/wiki/Q7799650","display_name":"Thymoquinone","level":3,"score":0.997905969619751},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.8337030410766602},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.681660532951355},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6779195666313171},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5907225012779236},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5269941687583923},{"id":"https://openalex.org/C2779985140","wikidata":"https://www.wikidata.org/wiki/Q1425425","display_name":"Drug tolerance","level":2,"score":0.4270384907722473},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.42579153180122375},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.4080141484737396},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35143953561782837},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2999590039253235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2056809663772583},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.08899739384651184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08533331751823425},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4884218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4884218/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4884218/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna J Phytomed","raw_type":"Text"},{"id":"pmid:27247922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27247922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna journal of phytomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:04fdaf2c69b94c34b3497c498d27a8f5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/04fdaf2c69b94c34b3497c498d27a8f5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Avicenna Journal of Phytomedicine, Vol 6, Iss 1, Pp 55-66 (2016)","raw_type":"article"},{"id":"mag:610485274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27247922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4884218","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4884218/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4884218/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna J Phytomed","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322855","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W610485274.pdf","grobid_xml":"https://content.openalex.org/works/W610485274.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1220703212","https://openalex.org/W1508011597","https://openalex.org/W1525713084","https://openalex.org/W1533049658","https://openalex.org/W1546931972","https://openalex.org/W1965255926","https://openalex.org/W1967361627","https://openalex.org/W1967465059","https://openalex.org/W1967990977","https://openalex.org/W1970870018","https://openalex.org/W1972849285","https://openalex.org/W1976824192","https://openalex.org/W1981372048","https://openalex.org/W1986782073","https://openalex.org/W1992347077","https://openalex.org/W1996815764","https://openalex.org/W1999494700","https://openalex.org/W2003153343","https://openalex.org/W2003382388","https://openalex.org/W2005415366","https://openalex.org/W2010455608","https://openalex.org/W2013785469","https://openalex.org/W2014555168","https://openalex.org/W2019467534","https://openalex.org/W2034394968","https://openalex.org/W2034440843","https://openalex.org/W2034921413","https://openalex.org/W2041770290","https://openalex.org/W2042796908","https://openalex.org/W2050248524","https://openalex.org/W2051675043","https://openalex.org/W2056318565","https://openalex.org/W2064860822","https://openalex.org/W2066505787","https://openalex.org/W2073181814","https://openalex.org/W2076715577","https://openalex.org/W2079708017","https://openalex.org/W2091017805","https://openalex.org/W2094881225","https://openalex.org/W2098498160","https://openalex.org/W2105499414","https://openalex.org/W2115378219","https://openalex.org/W2119656743","https://openalex.org/W2122057982","https://openalex.org/W2127097613","https://openalex.org/W2135404848","https://openalex.org/W2139374204","https://openalex.org/W2149659974","https://openalex.org/W2150254599","https://openalex.org/W2154853392","https://openalex.org/W2168339235","https://openalex.org/W2170015971","https://openalex.org/W2180405818","https://openalex.org/W2183038680","https://openalex.org/W2189210838","https://openalex.org/W2259858526","https://openalex.org/W2261491331","https://openalex.org/W2314352141","https://openalex.org/W2323537065","https://openalex.org/W2468250950","https://openalex.org/W2599913737","https://openalex.org/W2915343749","https://openalex.org/W2950649552","https://openalex.org/W3148954841"],"related_works":["https://openalex.org/W2022149076","https://openalex.org/W2041770290","https://openalex.org/W2468613100","https://openalex.org/W2493920959","https://openalex.org/W2170948133","https://openalex.org/W2001062253","https://openalex.org/W2504394926","https://openalex.org/W1559846837","https://openalex.org/W2089638316","https://openalex.org/W2810909099"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Dependence":[1],"and":[2,33,49,58,67,115,148,167,173,200,240],"tolerance":[3,34,83,114,186,239],"are":[4],"major":[5,24],"restricting":[6],"factors":[7],"in":[8,37,100,128,158],"the":[9,16,19,23,85,104,109,135,154,182,188,195,217,236],"clinical":[10],"use":[11],"of":[12,21,26,54,88,111,124,140,145,156,164,177,191,194,212,220,238],"opioid":[13],"analgesics.":[14],"In":[15],"present":[17],"study,":[18],"effects":[20,87,110,206],"thymoquinone,":[22],"constituent":[25],"Nigella":[27],"sativa":[28],"seeds,":[29],"on":[30,62,113,181,207,226],"morphine":[31,55,105,159],"dependence":[32,116,241],"were":[35,46,126],"investigated":[36],"mice.":[38,129],"MATERIALS":[39],"AND":[40],"METHODS:":[41],"Male":[42],"adult":[43],"NMRI":[44],"mice":[45],"made":[47],"tolerant":[48],"dependent":[50,160],"by":[51,216],"repeated":[52,122,143],"injections":[53],"(50,":[56],"50,":[57],"75":[59],"mg/kg,":[60,92,150,169,180],"i.p.":[61],"9":[63],"a.m.,":[64],"1":[65],"p.m.,":[66,69],"5":[68],"respectively)":[70],"during":[71],"a":[72],"3-day":[73],"administration":[74,163],"schedule.":[75],"The":[76],"hot-plate":[77],"test":[78],"was":[79,94,131,214],"used":[80,132],"to":[81,84,96,102,117,133,187,242],"assess":[82,103,134],"analgesic":[86,189],"morphine.":[89,192,243],"Naloxone":[90],"(2":[91],"i.p.)":[93,151],"injected":[95],"precipitate":[97],"withdrawal":[98],"syndrome":[99],"order":[101],"dependence.":[106],"To":[107],"evaluate":[108],"thymoquinone":[112,125,146,165,178,196,221,234],"morphine,":[118],"different":[119],"single":[120,141,175],"or":[121,142],"doses":[123,144,197],"administered":[127],"Rotarod":[130],"motor":[136],"coordination.":[137],"RESULTS:":[138],"Administration":[139],"(20":[147,166],"40":[149,168,201],"significantly":[152],"decreased":[153],"number":[155],"jumps":[157],"animals.":[161],"Repeated":[162],"for":[170],"3":[171],"days)":[172],"also":[174],"injection":[176],"(40":[179,222],"fourth":[183],"day)":[184],"attenuated":[185],"effect":[190],"None":[193],"(10,":[198],"20,":[199],"mg/kg)":[202],"produced":[203],"any":[204],"antinociceptive":[205],"their":[208],"own.":[209],"Motor":[210],"coordination":[211],"animals":[213],"impaired":[215],"high":[218],"dose":[219],"mg/kg).":[223],"CONCLUSION:":[224],"Based":[225],"these":[227],"results,":[228],"it":[229],"can":[230],"be":[231],"concluded":[232],"that":[233],"prevents":[235],"development":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}