{"id":"https://openalex.org/W610074159","doi":"https://doi.org/10.71781/28553","title":"Effet de la RNase HI sur l\u2019expression g\u00e9nique et sur le surenroulement de l\u2019ADN chez Escherichia coli","display_name":"Effet de la RNase HI sur l\u2019expression g\u00e9nique et sur le surenroulement de l\u2019ADN chez Escherichia coli","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W610074159","doi":"https://doi.org/10.71781/28553","mag":"610074159"},"language":"fr","primary_location":{"id":"pmh:doi:10.71781/28553","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1866/3981","pdf_url":"https://umontreal.scholaris.ca/bitstreams/c6756f18-34e9-49c4-9f12-383b9eb78787/download","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://umontreal.scholaris.ca/bitstreams/c6756f18-34e9-49c4-9f12-383b9eb78787/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073398437","display_name":"Flora Nolent","orcid":"https://orcid.org/0000-0002-3623-690X","observed_orcids":["https://orcid.org/0000-0002-3623-690X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nolent, Flora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073398437"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnase-hi","display_name":"RNase HI","score":0.9150000214576721},{"id":"https://openalex.org/keywords/r-loops","display_name":"R-loops","score":0.902999997138977},{"id":"https://openalex.org/keywords/dna-supercoiling","display_name":"DNA supercoiling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/topoisomerase-iv","display_name":"topoisomerase IV","score":0.7519999742507935},{"id":"https://openalex.org/keywords/topa","display_name":"topA","score":0.5120000243186951},{"id":"https://openalex.org/keywords/gyrase-inhibition","display_name":"gyrase inhibition","score":0.7929999828338623},{"id":"https://openalex.org/keywords/rna-degradation","display_name":"RNA degradation","score":0.5320000052452087},{"id":"https://openalex.org/keywords/truncated-protein","display_name":"truncated protein","score":0.8809999823570251},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8619999885559082},{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.4350000023841858},{"id":"https://openalex.org/keywords/dna-topology","display_name":"DNA topology","score":0.49000000953674316},{"id":"https://openalex.org/keywords/antibiotic-targets","display_name":"antibiotic targets","score":0.4050000011920929},{"id":"https://openalex.org/keywords/topoisomerase-inhibitors","display_name":"topoisomerase inhibitors","score":0.4950000047683716},{"id":"https://openalex.org/keywords/topoisomerase-iv-inhibitors","display_name":"topoisomerase IV inhibitors","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.8527106046676636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40514370799064636},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36241415143013},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34142228960990906}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:doi:10.71781/28553","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1866/3981","pdf_url":"https://umontreal.scholaris.ca/bitstreams/c6756f18-34e9-49c4-9f12-383b9eb78787/download","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:oai:papyrus.bib.umontreal.ca:1866/3981","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1866/3981","pdf_url":"http://hdl.handle.net/1866/3981","source":{"id":"https://openalex.org/S4306402422","display_name":"Papyrus : Institutional Repository (Universit\u00e9 de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70931966","host_organization_name":"Universit\u00e9 de Montr\u00e9al","host_organization_lineage":["https://openalex.org/I70931966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Th\u00e8se ou M\u00e9moire num\u00e9rique / Electronic Thesis or Dissertation"},{"id":"pmh:oai:umontreal.scholaris.ca:1866/3981","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1866/3981","pdf_url":null,"source":{"id":"https://openalex.org/S4306402422","display_name":"Papyrus : Institutional Repository (Universit\u00e9 de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70931966","host_organization_name":"Universit\u00e9 de Montr\u00e9al","host_organization_lineage":["https://openalex.org/I70931966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"doi:10.71781/28553","doi":"https://doi.org/10.71781/28553","is_oa":true,"landing_page_url":"https://doi.org/10.71781/28553","pdf_url":null,"source":{"id":"https://openalex.org/S4306402422","display_name":"Papyrus : Institutional Repository (Universit\u00e9 de Montr\u00e9al)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I70931966","host_organization_name":"Universit\u00e9 de Montr\u00e9al","host_organization_lineage":["https://openalex.org/I70931966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:610074159","doi":null,"is_oa":false,"landing_page_url":"https://papyrus.bib.umontreal.ca/xmlui/handle/1866/3981","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:doi:10.71781/28553","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1866/3981","pdf_url":"https://umontreal.scholaris.ca/bitstreams/c6756f18-34e9-49c4-9f12-383b9eb78787/download","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W610074159.pdf","grobid_xml":"https://content.openalex.org/works/W610074159.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2021738044"],"related_works":["https://openalex.org/W7067040485","https://openalex.org/W637997329","https://openalex.org/W1934544675","https://openalex.org/W2021738044","https://openalex.org/W2040843438","https://openalex.org/W1988621347","https://openalex.org/W2054197881","https://openalex.org/W2015818551","https://openalex.org/W2042240051","https://openalex.org/W2034973272"],"abstract_inverted_index":{"Les":[0],"R-loops":[1,77,142,198],"g\u00e9n\u00e9r\u00e9s":[2],"durant":[3,170],"la":[4,13,15,45,68,107,116,125,129,173,177,195,202,219,234,237,241,253,281],"transcription":[5,174],"sont":[6,151],"impliqu\u00e9s":[7],"dans":[8,128],"de":[9,34,47,65,70,98,115,124,133,172,197,201,207,221,243,252,258,266,277,289],"nombreuse":[10],"fonctions":[11],"incluant":[12],"r\u00e9plication,":[14],"recombinaison":[16],"et":[17,37,67,216,245],"l\u2019expression":[18,145,246],"g\u00e9nique":[19],"tant":[20],"chez":[21,25,295],"les":[22,26,61,121,141,148,296],"procaryotes":[23],"que":[24,140,189,276],"eucaryotes.":[27,298],"Plusieurs":[28],"\u00e9tudes":[29,227,285],"ont":[30,54,137],"montr\u00e9":[31,95,139],"qu\u2019un":[32],"exc\u00e8s":[33],"supertours":[35],"n\u00e9gatifs":[36],"des":[38,76,110,168,179,214,239,292],"s\u00e9quences":[39],"riches":[40],"en":[41],"bases":[42],"G":[43],"induisent":[44],"formation":[46,69,196,220,238],"R-loops.":[48,71],"Jusqu\u2019\u00e0":[49],"maintenant,":[50],"nos":[51],"r\u00e9sultats":[52,136],"nous":[53,187],"permis":[55],"d\u2019\u00e9tablir":[56],"un":[57],"lien":[58,231],"direct":[59],"entre":[60,233],"topoisom\u00e9rases,":[62],"le":[63,73,83,184],"niveau":[64],"surenroulement":[66,132],"Cependant,":[72,147],"r\u00f4le":[74],"physiologique":[75],"est":[78,273],"encore":[79,152,263],"largement":[80],"inconnu.":[81],"Dans":[82,183],"premier":[84],"article,":[85,186],"une":[86,102,211],"\u00e9tude":[87],"d\u00e9taill\u00e9e":[88],"du":[89,131],"double":[90],"mutant":[91],"topA":[92],"rnhA":[93],"a":[94],"qu\u2019une":[96],"d\u00e9pl\u00e9tion":[97],"RNase":[99,126,235],"HI":[100,127],"induit":[101],"r\u00e9ponse":[103],"cellulaire":[104],"qui":[105],"emp\u00eache":[106],"gyrase":[108,259],"d\u2019introduire":[109],"supertours.":[111],"Il":[112],"s\u2019agit":[113],"ici,":[114],"plus":[117],"forte":[118],"\u00e9vidence":[119],"supportant":[120],"r\u00f4les":[122],"majeurs":[123],"r\u00e9gulation":[130],"l\u2019ADN.":[134],"Nos":[135],"\u00e9galement":[138,288],"pouvaient":[143],"inhiber":[144],"g\u00e9nique.":[146,247],"m\u00e9canismes":[149],"exacts":[150],"mal":[153],"connus.":[154],"L\u2019accumulation":[155],"d\u2019ARNs":[156,160],"courts":[157],"au":[158],"d\u00e9triment":[159],"pleine":[161,181],"longueur":[162],"peut":[163,192],"\u00eatre":[164],"caus\u00e9e":[165],"soit":[166,175],"par":[167,176],"blocages":[169],"l\u2019\u00e9longation":[171],"d\u00e9gradation":[178,212],"ARNs":[180,215],"longueur.":[182],"deuxi\u00e8me":[185],"montrons":[188],"l\u2019hypersurenroulement":[190],"n\u00e9gatif":[191],"mener":[193],"\u00e0":[194,218,291],"non-sp\u00e9cifiques":[199],"(ind\u00e9pendants":[200],"s\u00e9quence":[203],"nucl\u00e9otidique).":[204],"La":[205],"pr\u00e9sence":[206,254],"ces":[208,226,284],"derniers,":[209],"engendre":[210],"massive":[213],"ultimement":[217],"prot\u00e9ines":[222],"tronqu\u00e9es.":[223],"En":[224],"conclusion,":[225],"montrent":[228],"l\u2019\u00e9vidence":[229],"d\u2019un":[230,255,261],"\u00e9troit":[232],"HI,":[236],"R-loops,":[240],"topologie":[242],"l\u2019ADN":[244],"De":[248],"plus,":[249],"elles":[250],"attestent":[251],"nouvel":[256],"inhibiteur":[257],"ou":[260],"m\u00e9canisme":[262],"inconnu":[264],"capable":[265],"r\u00e9guler":[267],"son":[268],"activit\u00e9.":[269],"Cette":[270],"surprenante":[271],"d\u00e9couverte":[272],"\u00e9l\u00e9mentaire":[274],"sachant":[275],"nombreux":[278],"antibiotiques":[279],"ciblent":[280],"gyrase.":[282],"Finalement,":[283],"pourront":[286],"servir":[287],"base":[290],"recherches":[293],"similaires":[294],"cellules":[297]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}