{"id":"https://openalex.org/W61003746","doi":null,"title":"Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.","display_name":"Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.","publication_year":1987,"publication_date":"1987-07-01","ids":{"openalex":"https://openalex.org/W61003746","mag":"61003746","pmid":"https://pubmed.ncbi.nlm.nih.gov/3114201"},"language":"en","primary_location":{"id":"pmid:3114201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3114201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022838755","display_name":"Kunihiko Tatsumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tatsumi","raw_affiliation_strings":["Biwako Research Institute, Otsuka Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biwako Research Institute, Otsuka Pharmaceutical Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112318990","display_name":"Masakazu Fukushima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Fukushima","raw_affiliation_strings":["Biwako Research Institute, Otsuka Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biwako Research Institute, Otsuka Pharmaceutical Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113793342","display_name":"Tetsuhiko Shirasaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Shirasaka","raw_affiliation_strings":["Biwako Research Institute, Otsuka Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biwako Research Institute, Otsuka Pharmaceutical Co., Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113490253","display_name":"Setsuro Fujii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Fujii","raw_affiliation_strings":["Biwako Research Institute, Otsuka Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biwako Research Institute, Otsuka Pharmaceutical Co., Ltd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.697,"has_fulltext":false,"cited_by_count":260,"citation_normalized_percentile":{"value":0.64916164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"78","issue":"7","first_page":"748","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.890999972820282},{"id":"https://openalex.org/keywords/pyrimidine-derivatives","display_name":"pyrimidine derivatives","score":0.9409999847412109},{"id":"https://openalex.org/keywords/barbiturates","display_name":"barbiturates","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pyridine-derivatives","display_name":"pyridine derivatives","score":0.9869999885559082},{"id":"https://openalex.org/keywords/5-substituted-uracils","display_name":"5-substituted uracils","score":0.8059999942779541},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2779793070","wikidata":"https://www.wikidata.org/wiki/Q410278","display_name":"Barbituric acid","level":2,"score":0.8365246057510376},{"id":"https://openalex.org/C2779554091","wikidata":"https://www.wikidata.org/wiki/Q182990","display_name":"Uracil","level":3,"score":0.7285071015357971},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.7226184010505676},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.5902022123336792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.586259126663208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49706605076789856},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.48564612865448},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38207772374153137},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.04532930254936218}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001463","descriptor_name":"Barbiturates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044925","descriptor_name":"Oxidoreductases Acting on CH-CH Group Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050744","descriptor_name":"Dihydrouracil Dehydrogenase (NAD+)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3114201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3114201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"},{"id":"mag:61003746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3114201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W83596241","https://openalex.org/W172055697","https://openalex.org/W1508983572","https://openalex.org/W1513611671","https://openalex.org/W1515227788","https://openalex.org/W1518352470","https://openalex.org/W1547366939","https://openalex.org/W1625790154","https://openalex.org/W1843522751","https://openalex.org/W1996141616","https://openalex.org/W2008794028","https://openalex.org/W2040428778","https://openalex.org/W2097466281","https://openalex.org/W2124608634","https://openalex.org/W2233869306","https://openalex.org/W2324513233","https://openalex.org/W2328073148","https://openalex.org/W2339778209","https://openalex.org/W2766031866"],"related_works":["https://openalex.org/W1526757995","https://openalex.org/W2008794028","https://openalex.org/W763496143","https://openalex.org/W1984282740","https://openalex.org/W2040428778","https://openalex.org/W2955333116","https://openalex.org/W1992976919","https://openalex.org/W2124608634","https://openalex.org/W2310743441","https://openalex.org/W1971722547"],"abstract_inverted_index":{"The":[0,23,63],"inhibitory":[1,24,64],"effects":[2],"of":[3,26,43,66,74,93,109,116,138],"about":[4],"30":[5],"compounds,":[6,124],"mainly":[7],"pyrimidine":[8],"and":[9,96,120,126,143],"pyridine":[10],"derivatives,":[11,58],"on":[12],"5-fluorouracil":[13],"degradation":[14],"catalyzed":[15],"by":[16],"dihydrouracil":[17],"dehydrogenase":[18,137],"(DHU":[19],"dehydrogenase)":[20],"were":[21,50,128],"investigated.":[22],"activities":[25],"5-substituted":[27],"uracil":[28],"derivatives":[29,49,115],"decreased":[30],"time-dependently":[31],"during":[32,79],"preincubation":[33],"with":[34,132],"liver":[35],"extracts,":[36],"indicating":[37,81],"that":[38,73,82,98],"these":[39,110,123],"compounds":[40],"are":[41],"substrates":[42],"DHU":[44,94,136],"dehydrogenase.":[45],"During":[46],"preincubation,":[47,80],"4,6-dihydroxypyrimidine":[48],"found":[51],"to":[52,55],"be":[53,102],"converted":[54],"barbituric":[56,117],"acid":[57],"which":[59,69],"have":[60],"stronger":[61,71],"activities.":[62],"activity":[65],"2,4-dihydroxypyridine":[67,119],"(3-deazauracil),":[68],"was":[70],"than":[72],"uracil,":[75],"did":[76],"not":[77,86],"change":[78],"this":[83],"compound":[84],"is":[85,90],"a":[87,103],"substrate":[88],"but":[89],"an":[91],"inhibitor":[92],"dehydrogenase,":[95],"suggesting":[97],"2,6-dihydroxypyridine":[99],"(1-deazauracil)":[100],"could":[101],"potent":[104],"inhibitor.":[105],"In":[106],"the":[107,129],"light":[108],"findings,":[111],"we":[112],"examined":[113],"various":[114],"acid,":[118],"2,6-dihydroxypyridine.":[121],"Among":[122],"3-cyano-2,6-dihydroxypyridine":[125],"5-chloro-2,4-dihydroxypyridine":[127],"strongest":[130],"inhibitors":[131],"Ki":[133],"values":[134],"for":[135],"2.3":[139],"X":[140,145],"10(-7)":[141,146],"M":[142],"3.6":[144],"M,":[147],"respectively.":[148]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}