{"id":"https://openalex.org/W60966937","doi":null,"title":"Experimental Evolution of Fission Yeast Genomes in Response to Repeated Environmental Changes","display_name":"Experimental Evolution of Fission Yeast Genomes in Response to Repeated Environmental Changes","publication_year":2013,"publication_date":"2013-08-28","ids":{"openalex":"https://openalex.org/W60966937","mag":"60966937"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1404384","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1404384/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004346098","display_name":"Van Trigt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Van Trigt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004346098"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.9860000014305115},{"id":"https://openalex.org/keywords/schizosaccharomyces-pombe","display_name":"Schizosaccharomyces pombe","score":0.9570000171661377},{"id":"https://openalex.org/keywords/heat-shock","display_name":"heat shock","score":0.734000027179718},{"id":"https://openalex.org/keywords/stress-tolerance","display_name":"stress tolerance","score":0.7229999899864197},{"id":"https://openalex.org/keywords/genome-evolution","display_name":"genome evolution","score":0.46700000762939453},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.578000009059906},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/growth-recovery","display_name":"growth recovery","score":0.41600000858306885},{"id":"https://openalex.org/keywords/population-genomics","display_name":"population genomics","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.7130764126777649},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7000077962875366},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5728247165679932},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5145891904830933},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4644581973552704},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4466731548309326},{"id":"https://openalex.org/C12294094","wikidata":"https://www.wikidata.org/wiki/Q929080","display_name":"Fission","level":3,"score":0.4362500309944153},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.43264269828796387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4072282016277313},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.38000619411468506},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3640349507331848},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2355961799621582},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C152568617","wikidata":"https://www.wikidata.org/wiki/Q2348","display_name":"Neutron","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1404384","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1404384/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:60966937","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/1404384/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W184712960","https://openalex.org/W566407040","https://openalex.org/W1480307447","https://openalex.org/W1550678611","https://openalex.org/W1798315881","https://openalex.org/W1901855704","https://openalex.org/W1964813475","https://openalex.org/W1966930245","https://openalex.org/W1971112779","https://openalex.org/W1972316915","https://openalex.org/W1972848138","https://openalex.org/W1976319140","https://openalex.org/W1977918604","https://openalex.org/W1985687704","https://openalex.org/W1986301417","https://openalex.org/W1988825409","https://openalex.org/W1992909271","https://openalex.org/W1993400812","https://openalex.org/W1995164578","https://openalex.org/W1998083475","https://openalex.org/W2006492816","https://openalex.org/W2012458247","https://openalex.org/W2012980277","https://openalex.org/W2014496483","https://openalex.org/W2018555631","https://openalex.org/W2023665511","https://openalex.org/W2023925845","https://openalex.org/W2024083852","https://openalex.org/W2025465336","https://openalex.org/W2026083933","https://openalex.org/W2027111847","https://openalex.org/W2028979517","https://openalex.org/W2031141619","https://openalex.org/W2031581341","https://openalex.org/W2039013541","https://openalex.org/W2039931639","https://openalex.org/W2043257091","https://openalex.org/W2045391589","https://openalex.org/W2047646534","https://openalex.org/W2048086011","https://openalex.org/W2053389510","https://openalex.org/W2056613057","https://openalex.org/W2060915805","https://openalex.org/W2067682358","https://openalex.org/W2067713285","https://openalex.org/W2068206509","https://openalex.org/W2068689381","https://openalex.org/W2069780164","https://openalex.org/W2069784990","https://openalex.org/W2070380923","https://openalex.org/W2071636295","https://openalex.org/W2072201802","https://openalex.org/W2073911144","https://openalex.org/W2075743026","https://openalex.org/W2077214326","https://openalex.org/W2087903825","https://openalex.org/W2094057369","https://openalex.org/W2095285341","https://openalex.org/W2097477395","https://openalex.org/W2098722656","https://openalex.org/W2100481775","https://openalex.org/W2104254337","https://openalex.org/W2107028052","https://openalex.org/W2110032040","https://openalex.org/W2112743201","https://openalex.org/W2112945902","https://openalex.org/W2113430775","https://openalex.org/W2113553538","https://openalex.org/W2116402707","https://openalex.org/W2116599270","https://openalex.org/W2118055782","https://openalex.org/W2118233702","https://openalex.org/W2120129282","https://openalex.org/W2120624021","https://openalex.org/W2128773672","https://openalex.org/W2130005065","https://openalex.org/W2131897837","https://openalex.org/W2131964524","https://openalex.org/W2134638996","https://openalex.org/W2134809769","https://openalex.org/W2138138136","https://openalex.org/W2140299962","https://openalex.org/W2141046490","https://openalex.org/W2142132211","https://openalex.org/W2143374251","https://openalex.org/W2143941462","https://openalex.org/W2144386534","https://openalex.org/W2148033110","https://openalex.org/W2150012832","https://openalex.org/W2151871788","https://openalex.org/W2153685804","https://openalex.org/W2158877641","https://openalex.org/W2162152219","https://openalex.org/W2162237438","https://openalex.org/W2162251727","https://openalex.org/W2165017975","https://openalex.org/W2165081628","https://openalex.org/W2165628852","https://openalex.org/W2167082076","https://openalex.org/W2168522547","https://openalex.org/W2170392103","https://openalex.org/W2170568588","https://openalex.org/W2170671396","https://openalex.org/W2171679524","https://openalex.org/W2171950816","https://openalex.org/W2334084376","https://openalex.org/W2883512297","https://openalex.org/W4295837538"],"related_works":["https://openalex.org/W1805449453","https://openalex.org/W6892229075","https://openalex.org/W4389023425","https://openalex.org/W2170568588","https://openalex.org/W4308253979","https://openalex.org/W7028347601","https://openalex.org/W1964278573","https://openalex.org/W7124467274","https://openalex.org/W7223421628","https://openalex.org/W7099450121"],"abstract_inverted_index":{"Evolutionary":[0],"biology":[1],"has":[2],"mainly":[3],"relied":[4],"on":[5,180],"comparative":[6],"studies.":[7],"Supported":[8],"by":[9,61,167],"the":[10,27,104,142,163,184,199,219,222,239,244,249,255,281,287,298,313],"advances":[11],"in":[12,135,170,232,238,258],"genomics,":[13],"several":[14],"groups":[15],"are":[16,187,253],"now":[17],"using":[18,204],"microorganisms":[19],"for":[20,72,86,103],"experimental":[21,45],"evolution":[22,28,46,223],"studies":[23],"to":[24,39,56,88,113,177,285,297],"directly":[25],"observe":[26],"process":[29],"and":[30,75,115,157,192,207,234],"its":[31],"genetic":[32,230],"basis.":[33],"To":[34],"understand":[35],"how":[36],"cells":[37,107,283],"adapt":[38],"an":[40],"environmental":[41],"stress,":[42],"I":[43,80],"developed":[44],"assays":[47,206],"during":[48,124],"which":[49,308],"fission":[50],"yeast":[51],"populations":[52],"were":[53,66,202,225],"repeatedly":[54],"exposed":[55],"short":[57],"heat-shocks,":[58],"followed":[59],"immediately":[60],"ideal":[62],"growth":[63,153,164,318],"conditions.":[64],"Samples":[65],"frozen":[67],"after":[68,319],"each":[69,276],"selection":[70,90,121],"cycle":[71],"subsequent":[73],"phenotypic":[74],"genotypic":[76],"analyses.":[77],"In":[78,99,260],"total,":[79],"performed":[81],"10":[82],"independent":[83,241],"such":[84],"experiments":[85,224],"up":[87],"150":[89],"cycles,":[91,122],"including":[92,141],"a":[93,109,129,147,158,301],"control":[94],"experiment":[95],"with":[96,243,262,312],"mock-treated":[97,105,143],"samples.":[98],"all":[100,139],"experiments,":[101,242],"except":[102],"control,":[106,144],"acquired":[108],"markedly":[110],"increased":[111],"survival":[112],"heat":[114,155,320],"other":[116],"stresses":[117],"within":[118],"only":[119],"10-20":[120],"while":[123],"later":[125],"cycles":[126],"there":[127],"was":[128],"more":[130,148,159,314],"subtle":[131],"but":[132],"continuous":[133],"increase":[134],"stress":[136,205],"resistance.":[137],"Surprisingly,":[138],"populations,":[140],"also":[145],"evolved":[146,200],"rapid":[149,174,288,315],"re-initiation":[150],"of":[151,162,195,198,211,221,247,291,300,305,317],"exponential":[152],"following":[154],"shock":[156],"efficient":[160],"use":[161],"medium,":[165],"reflected":[166],"higher":[168],"biomass":[169],"stationary":[171],"phase.":[172],"These":[173],"adaptations":[175],"seem":[176],"be":[178],"based":[179],"DNA":[181,208],"variations":[182],"as":[183],"new":[185,292],"phenotypes":[186,191],"stable.":[188],"The":[189],"cellular":[190],"global":[193],"regulation":[194],"gene":[196],"expression":[197],"strains":[201,213],"determined":[203,267],"microarrays.":[209],"Genomes":[210],"96":[212],"at":[214],"selected":[215],"time":[216],"points":[217],"over":[218],"course":[220],"sequenced.":[226],"We":[227],"analyzed":[228],"what":[229],"changes":[231,251],"regulatory":[233],"coding":[235],"regions":[236],"occurred":[237],"different":[240],"ultimate":[245],"goal":[246],"uncovering":[248],"specific":[250],"that":[252,272],"causing":[254],"striking":[256],"alteration":[257],"phenotype.":[259],"collaboration":[261],"Dr.":[263],"Ville":[264],"Mustonen,":[265],"we":[266],"dynamic":[268],"allele":[269],"frequency":[270],"trajectories":[271],"had":[273],"swept":[274],"through":[275],"population.":[277],"Genetic":[278],"variation":[279],"among":[280],"parental":[282],"seems":[284],"underlie":[286],"initial":[289],"adaptation":[290],"phenotypes.":[293],"This":[294],"analysis":[295],"led":[296],"discovery":[299],"common":[302],"haplotype":[303],"consisting":[304],"9":[306],"mutations,":[307],"is":[309],"likely":[310],"associated":[311],"recovery":[316],"shock.":[321]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}