{"id":"https://openalex.org/W609294460","doi":null,"title":"A Meta-Analysis of Association Between One-Carbon Metabolism Gene Polymorphisms and Risk of Prostate Cancer","display_name":"A Meta-Analysis of Association Between One-Carbon Metabolism Gene Polymorphisms and Risk of Prostate Cancer","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W609294460","mag":"609294460"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.waldenu.edu:dissertations-1405","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.waldenu.edu/dissertations/406","pdf_url":"https://scholarworks.waldenu.edu/dissertations/406","source":{"id":"https://openalex.org/S4377196507","display_name":"ScholarWorks (Walden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80046288","host_organization_name":"Walden University","host_organization_lineage":["https://openalex.org/I80046288"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Walden Dissertations and Doctoral Studies","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.waldenu.edu/dissertations/406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026156423","display_name":"Mahmood Tazari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80046288","display_name":"Walden University","ror":"https://ror.org/02qp2hh41","country_code":"US","type":"education","lineage":["https://openalex.org/I80046288"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mahmood Tazari","raw_affiliation_strings":["Walden Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walden Univ","institution_ids":["https://openalex.org/I80046288"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026156423"],"corresponding_institution_ids":["https://openalex.org/I80046288"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.49390000104904175,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.49390000104904175,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.08590000122785568,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.984000027179718},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9829999804496765},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5879999995231628},{"id":"https://openalex.org/keywords/genetic-epidemiology","display_name":"genetic epidemiology","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7819234728813171},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7112438678741455},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6686939001083374},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5745791792869568},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5310379266738892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4432871639728546},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40243202447891235},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.39991259574890137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39600658416748047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37799710035324097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32253390550613403},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.282368928194046}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.waldenu.edu:dissertations-1405","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.waldenu.edu/dissertations/406","pdf_url":"https://scholarworks.waldenu.edu/dissertations/406","source":{"id":"https://openalex.org/S4377196507","display_name":"ScholarWorks (Walden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80046288","host_organization_name":"Walden University","host_organization_lineage":["https://openalex.org/I80046288"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Walden Dissertations and Doctoral Studies","raw_type":"text"},{"id":"mag:609294460","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.waldenu.edu/cgi/viewcontent.cgi?article=1405&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarworks.waldenu.edu:dissertations-1405","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.waldenu.edu/dissertations/406","pdf_url":"https://scholarworks.waldenu.edu/dissertations/406","source":{"id":"https://openalex.org/S4377196507","display_name":"ScholarWorks (Walden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80046288","host_organization_name":"Walden University","host_organization_lineage":["https://openalex.org/I80046288"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Walden Dissertations and Doctoral Studies","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W609294460.pdf","grobid_xml":"https://content.openalex.org/works/W609294460.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W71228264","https://openalex.org/W92486268","https://openalex.org/W114200160","https://openalex.org/W194334592","https://openalex.org/W214964446","https://openalex.org/W1504213150","https://openalex.org/W1512714371","https://openalex.org/W1522407177","https://openalex.org/W1548668976","https://openalex.org/W1556838594","https://openalex.org/W1572079547","https://openalex.org/W1574663401","https://openalex.org/W1583327278","https://openalex.org/W1652923215","https://openalex.org/W1667831672","https://openalex.org/W1714723801","https://openalex.org/W1844223813","https://openalex.org/W1866291481","https://openalex.org/W1933482556","https://openalex.org/W1964887086","https://openalex.org/W1965766790","https://openalex.org/W1966095410","https://openalex.org/W1972123809","https://openalex.org/W1986226965","https://openalex.org/W1990239685","https://openalex.org/W1992147444","https://openalex.org/W1992332433","https://openalex.org/W1998039754","https://openalex.org/W1998977949","https://openalex.org/W2000432796","https://openalex.org/W2002146355","https://openalex.org/W2016686641","https://openalex.org/W2017571991","https://openalex.org/W2017844394","https://openalex.org/W2020720070","https://openalex.org/W2022641359","https://openalex.org/W2029513761","https://openalex.org/W2032580335","https://openalex.org/W2045746568","https://openalex.org/W2047798313","https://openalex.org/W2048165403","https://openalex.org/W2052355595","https://openalex.org/W2055432411","https://openalex.org/W2060967205","https://openalex.org/W2063575312","https://openalex.org/W2065989613","https://openalex.org/W2066179736","https://openalex.org/W2067548721","https://openalex.org/W2067722551","https://openalex.org/W2072126757","https://openalex.org/W2076100784","https://openalex.org/W2079585801","https://openalex.org/W2095792612","https://openalex.org/W2101606555","https://openalex.org/W2103906122","https://openalex.org/W2110836885","https://openalex.org/W2111628008","https://openalex.org/W2112226957","https://openalex.org/W2123869442","https://openalex.org/W2125435699","https://openalex.org/W2125947442","https://openalex.org/W2126602143","https://openalex.org/W2128785207","https://openalex.org/W2128883808","https://openalex.org/W2133234163","https://openalex.org/W2136721576","https://openalex.org/W2137008366","https://openalex.org/W2137339256","https://openalex.org/W2141325183","https://openalex.org/W2141794685","https://openalex.org/W2144798584","https://openalex.org/W2150943090","https://openalex.org/W2152579567","https://openalex.org/W2153298670","https://openalex.org/W2153501396","https://openalex.org/W2154103858","https://openalex.org/W2155053630","https://openalex.org/W2155708732","https://openalex.org/W2156852925","https://openalex.org/W2159803932","https://openalex.org/W2162923066","https://openalex.org/W2185159407","https://openalex.org/W2189426875","https://openalex.org/W2523609793","https://openalex.org/W4234973412","https://openalex.org/W4235457469"],"related_works":["https://openalex.org/W2074056530","https://openalex.org/W1981772710","https://openalex.org/W2006367514","https://openalex.org/W1537282572","https://openalex.org/W1986226965","https://openalex.org/W2913977356","https://openalex.org/W4391261632","https://openalex.org/W2472250032","https://openalex.org/W2077122054","https://openalex.org/W2306353282"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,6,34,121,169],"is":[2],"the":[3,41,44,68,77,90,97,105,123,131,138,141,154,177,183],"most":[4],"common":[5],"among":[7],"men.":[8],"The":[9,36,46,80],"purpose":[10],"of":[11,26,108,119,125,134,151,156,167,179,216],"this":[12],"quantitative,":[13],"meta-analysis":[14,86],"study":[15,102,187,227],"was":[16,112,163],"to":[17,28,95,101,189,201,225],"examine":[18],"one-carbon":[19],"metabolism":[20],"gene":[21],"polymorphisms":[22],"in":[23,76,170,182],"a":[24,85,113,145,213],"group":[25],"genes":[27],"determine":[29],"their":[30],"association":[31,115,147],"with":[32,212],"prostate":[33,120,152,168,207],"risk.":[35],"genetic":[37],"epidemiology":[38],"theory":[39],"provided":[40],"framework":[42],"for":[43,62,206],"study.":[45],"data":[47,65,81],"collected":[48],"were":[49,60,82],"from":[50,92],"published":[51],"articles.":[52],"From":[53],"over":[54],"2,800":[55],"individual":[56],"studies,":[57],"20":[58],"articles":[59],"retained":[61],"results":[63,91,103],"and":[64,72,122,130,159,222],"abstraction,":[66],"following":[67],"title,":[69],"abstract":[70],"screen,":[71],"full":[73],"text":[74],"screening":[75,204],"second":[78],"phase.":[79],"analyzed":[83],"by":[84,104,173,193],"statistical":[87],"method,":[88],"combining":[89],"selected":[93],"studies":[94,211],"estimate":[96],"overall":[98],"association.":[99],"According":[100],"adjusted":[106,142,174],"p-values":[107,143],"fixed":[109,184],"model,":[110,140],"there":[111],"significant":[114,146],"between":[116,148],"decreased":[117,149],"risk":[118,150,166],"variant":[124,155,178],"Allele":[126],"T,":[127],"Genotype":[128,157,180],"TT,":[129,158],"recessive":[132,160],"model":[133],"C667T":[135],"polymorphism.":[136],"In":[137],"random":[139],"show":[144],"cancer,":[153],"model.":[161,185],"There":[162],"an":[164,197],"increased":[165],"A1298C":[171],"polymorphism":[172],"p-value":[175],"on":[176,196],"AC,":[181],"This":[186],"leads":[188],"positive":[190],"social":[191],"change":[192],"providing":[194],"information":[195],"optimization":[198],"surveillance":[199],"strategy":[200],"ensure":[202],"valid":[203],"test":[205],"disease":[208],"reporting.":[209],"Future":[210],"greater":[214],"number":[215],"samples":[217],"are":[218],"needed,":[219],"including":[220],"gene-gene":[221],"gene-environment":[223],"interaction":[224],"verify":[226],"results.":[228]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}