{"id":"https://openalex.org/W60865655","doi":null,"title":"The role of HEB and E2A in the regulation of T Lymphocyte development and proliferation","display_name":"The role of HEB and E2A in the regulation of T Lymphocyte development and proliferation","publication_year":2007,"publication_date":"2007-05-10","ids":{"openalex":"https://openalex.org/W60865655","mag":"60865655"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/214","pdf_url":"http://hdl.handle.net/10161/214","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/214","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026606048","display_name":"Jason Wojciechowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jason Wojciechowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026606048"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heb","display_name":"HEB","score":0.9750000238418579},{"id":"https://openalex.org/keywords/e2a","display_name":"E2A","score":0.996999979019165},{"id":"https://openalex.org/keywords/e-protein","display_name":"E protein","score":0.8429999947547913},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.9789999723434448},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/thymocyte-proliferation","display_name":"thymocyte proliferation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/conditional-knockout","display_name":"conditional knockout","score":0.7070000171661377},{"id":"https://openalex.org/keywords/functional-redundancy","display_name":"functional redundancy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/il-7-signaling","display_name":"IL-7 signaling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pre-t-cell-receptor","display_name":"pre-T cell receptor","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2777045944","wikidata":"https://www.wikidata.org/wiki/Q12170198","display_name":"Zh\u00e0ng","level":3,"score":0.5610240697860718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5009193420410156},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.44315677881240845},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.38223761320114136},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.35763809084892273},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.33278924226760864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2963797450065613},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.24239769577980042},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.236200213432312},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.12095648050308228},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09587818384170532},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.056629329919815063},{"id":"https://openalex.org/C191935318","wikidata":"https://www.wikidata.org/wiki/Q148","display_name":"China","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/214","pdf_url":"http://hdl.handle.net/10161/214","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:60865655","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/handle/10161/214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/214","pdf_url":"http://hdl.handle.net/10161/214","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W60865655.pdf","grobid_xml":"https://content.openalex.org/works/W60865655.grobid-xml"},"referenced_works_count":188,"referenced_works":["https://openalex.org/W3203413","https://openalex.org/W14592976","https://openalex.org/W26449728","https://openalex.org/W258316223","https://openalex.org/W1479718839","https://openalex.org/W1486421511","https://openalex.org/W1505072532","https://openalex.org/W1507229894","https://openalex.org/W1522876936","https://openalex.org/W1527612372","https://openalex.org/W1532051891","https://openalex.org/W1536953298","https://openalex.org/W1575016278","https://openalex.org/W1576142340","https://openalex.org/W1579102917","https://openalex.org/W1605939038","https://openalex.org/W1646719553","https://openalex.org/W1668774261","https://openalex.org/W1692495181","https://openalex.org/W1719259611","https://openalex.org/W1748564991","https://openalex.org/W1763915099","https://openalex.org/W1773480859","https://openalex.org/W1775427038","https://openalex.org/W1834788462","https://openalex.org/W1841999755","https://openalex.org/W1879871130","https://openalex.org/W1920024920","https://openalex.org/W1964490621","https://openalex.org/W1968561263","https://openalex.org/W1968566025","https://openalex.org/W1970693469","https://openalex.org/W1971496886","https://openalex.org/W1972044265","https://openalex.org/W1972658032","https://openalex.org/W1975092706","https://openalex.org/W1976811239","https://openalex.org/W1977812814","https://openalex.org/W1978798271","https://openalex.org/W1982086162","https://openalex.org/W1983507527","https://openalex.org/W1984683131","https://openalex.org/W1988278983","https://openalex.org/W1989297216","https://openalex.org/W1992031335","https://openalex.org/W1992048975","https://openalex.org/W1992438206","https://openalex.org/W1993358535","https://openalex.org/W1996015314","https://openalex.org/W1996713852","https://openalex.org/W1996822762","https://openalex.org/W1997936885","https://openalex.org/W1998373798","https://openalex.org/W1999582446","https://openalex.org/W2002573132","https://openalex.org/W2002964039","https://openalex.org/W2009063507","https://openalex.org/W2010639752","https://openalex.org/W2010731453","https://openalex.org/W2014067834","https://openalex.org/W2015216415","https://openalex.org/W2015446431","https://openalex.org/W2016136969","https://openalex.org/W2016293652","https://openalex.org/W2018038111","https://openalex.org/W2019112133","https://openalex.org/W2019552337","https://openalex.org/W2020002041","https://openalex.org/W2020330574","https://openalex.org/W2023990373","https://openalex.org/W2028412132","https://openalex.org/W2028735719","https://openalex.org/W2029350186","https://openalex.org/W2032427842","https://openalex.org/W2034433166","https://openalex.org/W2034980526","https://openalex.org/W2035532250","https://openalex.org/W2041742410","https://openalex.org/W2043408306","https://openalex.org/W2044057392","https://openalex.org/W2044248487","https://openalex.org/W2048721919","https://openalex.org/W2049470832","https://openalex.org/W2055446110","https://openalex.org/W2056392767","https://openalex.org/W2056429839","https://openalex.org/W2058203815","https://openalex.org/W2061183445","https://openalex.org/W2064302244","https://openalex.org/W2064629639","https://openalex.org/W2065025453","https://openalex.org/W2065163855","https://openalex.org/W2065388713","https://openalex.org/W2065733932","https://openalex.org/W2065797900","https://openalex.org/W2067194336","https://openalex.org/W2067467034","https://openalex.org/W2067557830","https://openalex.org/W2068903461","https://openalex.org/W2070552972","https://openalex.org/W2070640889","https://openalex.org/W2071894403","https://openalex.org/W2077799380","https://openalex.org/W2080230456","https://openalex.org/W2082670705","https://openalex.org/W2082694975","https://openalex.org/W2083195750","https://openalex.org/W2083612972","https://openalex.org/W2084659477","https://openalex.org/W2085555998","https://openalex.org/W2085723888","https://openalex.org/W2087760361","https://openalex.org/W2087832707","https://openalex.org/W2089633707","https://openalex.org/W2091403769","https://openalex.org/W2094222260","https://openalex.org/W2094859123","https://openalex.org/W2095016279","https://openalex.org/W2095960380","https://openalex.org/W2096632716","https://openalex.org/W2099546426","https://openalex.org/W2100765613","https://openalex.org/W2102391679","https://openalex.org/W2102670644","https://openalex.org/W2103054294","https://openalex.org/W2103917924","https://openalex.org/W2108491220","https://openalex.org/W2108559706","https://openalex.org/W2109663412","https://openalex.org/W2109769177","https://openalex.org/W2110074960","https://openalex.org/W2111613650","https://openalex.org/W2114700924","https://openalex.org/W2115419666","https://openalex.org/W2115622973","https://openalex.org/W2116242175","https://openalex.org/W2118010774","https://openalex.org/W2118988718","https://openalex.org/W2119483052","https://openalex.org/W2120141012","https://openalex.org/W2120223283","https://openalex.org/W2121619780","https://openalex.org/W2123836839","https://openalex.org/W2125131118","https://openalex.org/W2126464081","https://openalex.org/W2126846584","https://openalex.org/W2128037490","https://openalex.org/W2128197399","https://openalex.org/W2128591721","https://openalex.org/W2131443076","https://openalex.org/W2131670992","https://openalex.org/W2132207544","https://openalex.org/W2137500713","https://openalex.org/W2137931232","https://openalex.org/W2139056292","https://openalex.org/W2140489687","https://openalex.org/W2141231618","https://openalex.org/W2143771791","https://openalex.org/W2144148102","https://openalex.org/W2144328523","https://openalex.org/W2144447876","https://openalex.org/W2145158048","https://openalex.org/W2149627687","https://openalex.org/W2149939821","https://openalex.org/W2150876347","https://openalex.org/W2152028923","https://openalex.org/W2152547527","https://openalex.org/W2153030091","https://openalex.org/W2153188235","https://openalex.org/W2153713615","https://openalex.org/W2156423848","https://openalex.org/W2157853291","https://openalex.org/W2158169658","https://openalex.org/W2158849813","https://openalex.org/W2159511823","https://openalex.org/W2159659449","https://openalex.org/W2162743131","https://openalex.org/W2163427031","https://openalex.org/W2164309169","https://openalex.org/W2165495560","https://openalex.org/W2166314938","https://openalex.org/W2171824690","https://openalex.org/W2182786267","https://openalex.org/W2183322892","https://openalex.org/W4255925221","https://openalex.org/W4298304887","https://openalex.org/W4313333773","https://openalex.org/W4313347722"],"related_works":["https://openalex.org/W2099546426","https://openalex.org/W2026020120","https://openalex.org/W2009063507","https://openalex.org/W1920024920","https://openalex.org/W2100765613","https://openalex.org/W2042397730","https://openalex.org/W2109769177","https://openalex.org/W2010480407","https://openalex.org/W2142951057","https://openalex.org/W2952034057"],"abstract_inverted_index":{"Thymocyte":[0],"development":[1,201,225],"is":[2],"a":[3,47,55,83,167,174,221,238,249],"complex":[4],"process":[5],"that":[6,122,202,212,274,307],"requires":[7],"precise":[8],"regulation":[9],"of\\ndifferentiation":[10],"and":[11,29,32,57,71,76,103,141,152,197,217,262,276,315],"proliferation.":[12,316],"Basic":[13],"helix-loop-helix":[14],"(bHLH)":[15],"transcription":[16],"factors\\nhave":[17],"been":[18],"shown":[19],"to":[20,153,178,229,269,292,300,311],"be":[21],"crucial":[22],"for":[23,52,195,282],"proper":[24],"T":[25,72,156,285],"cell":[26,73,157,286],"development.":[27,185],"HEB":[28,196,216,277],"E2A":[30,198,218,275],"are\\nstructurally":[31],"functionally":[33],"related":[34],"E":[35,89,97,106,125,146,308],"proteins":[36,98],"of":[37,46,49,63,69,82,93,105,160,215,251],"the":[38,44,67,101,155,227,283],"bHLH":[39],"family.":[40],"These":[41,254],"proteins\\ndirectly":[42],"regulate":[43],"expression":[45],"number":[48],"genes":[50],"essential":[51],"lymphocyte\\ndevelopment":[53],"in":[54,66,117,199,205,220,241,247,260,267,296],"lineage-":[56],"stage-specific":[58],"manner.":[59],"Abrogation":[60],"or":[61],"compromise":[62],"their\\nfunction":[64],"results":[65,219,305],"manifestation":[68],"B":[70],"developmental":[74,234],"defects.\\nGenetic":[75],"biochemical":[77],"studies":[78],"have":[79],"provided":[80],"evidence":[81],"significant":[84],"degree":[85],"of\\nfunctional":[86],"redundancy":[87],"among":[88],"proteins.":[90],"The":[91],"existence":[92],"compensational":[94],"abilities\\namong":[95],"different":[96],"has":[99],"hampered":[100],"investigation":[102],"elucidation":[104],"protein\\nfunction.":[107],"As":[108],"such,":[109],"single":[110,207],"gene":[111,133,208],"knockouts":[112,121,134],"demonstrate":[113],"only":[114,280],"limited":[115],"defects":[116,143],"lymphocyte\\ndevelopment.":[118],"Double":[119],"E2A-HEB":[120],"could":[123],"eliminate":[124,149],"protein":[126,147],"redundancy\\nare":[127],"embryonic":[128],"lethal.":[129],"In":[130],"addition,":[131],"conventional":[132],"are":[135,278,289],"not":[136,279],"well-suited":[137],"for\\ndiscerning":[138],"between":[139],"intrinsic":[140,158],"extrinsic":[142],"caused":[144],"by":[145,237],"disruption.\\nTo":[148],"functional":[150],"compensation":[151],"test":[154],"roles":[159,194],"E\\nproteins":[161],"during":[162,182],"thymocyte":[163,184,200,313],"development,":[164],"we":[165,172,189],"developed":[166],"conditional":[168],"HEB-E2A":[169],"double\\nknockout.":[170],"Specifically,":[171],"employed":[173],"loxP/Lck-Cre":[175],"recombinase":[176],"system":[177],"drive":[179],"E\\nprotein":[180],"deletion":[181,214],"early":[183],"Using":[186],"this":[187],"approach,":[188],"were":[190],"able\\nto":[191],"reveal":[192],"overlapping":[193],"had":[203],"been\\nobscured":[204],"previous":[206],"knockout":[209],"studies.\\nWe":[210],"find":[211],"simultaneous":[213],"severe":[222],"block":[223,235],"in\\nthymocyte":[224],"at":[226],"DN":[228],"DP":[230],"stage":[231],"transition.":[232],"This":[233],"is\\naccompanied":[236],"dramatic":[239,263],"decrease":[240],"total":[242],"thymic":[243],"cellularity,":[244],"an":[245],"increase":[246],"apoptosis,\\nand":[248],"reduction":[250],"pT\u03b1":[252],"expression.":[253,302],"developmentally":[255],"arrested":[256],"thymocytes":[257,295],"exhibit\\nincreased":[258],"proliferation":[259],"vivo":[261,266],"expansion":[264],"ex":[265],"response":[268],"IL-7\\nsignaling.":[270],"Our":[271],"findings":[272],"suggest":[273],"critical":[281],"regulation\\nof":[284],"differentiation":[287,314],"but":[288],"also":[290],"necessary":[291],"retain":[293],"developing":[294],"cell\\ncycle":[297],"arrest":[298],"prior":[299],"pre-TCR":[301],"Together,":[303],"these":[304],"imply":[306],"proteins\\nare":[309],"required":[310],"coordinate":[312]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}