{"id":"https://openalex.org/W608628564","doi":null,"title":"The Significance of Dehydroepiandrosterone for Fatigue in primary Sj\u00f6gren\u2019s Syndrome and Systemic Lupus Erythematosus","display_name":"The Significance of Dehydroepiandrosterone for Fatigue in primary Sj\u00f6gren\u2019s Syndrome and Systemic Lupus Erythematosus","publication_year":2014,"publication_date":"2014-11-11","ids":{"openalex":"https://openalex.org/W608628564","mag":"608628564"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/299917","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/299917","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/299917","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073922172","display_name":"A Hartkamp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A Hartkamp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073922172"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.34130001068115234,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.34130001068115234,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.24979999661445618,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.23360000550746918,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dhea-supplementation","display_name":"DHEA supplementation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.7279999852180481},{"id":"https://openalex.org/keywords/primary-sjogren-syndrome","display_name":"primary Sj\u00f6gren's syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/dhea-sulfate","display_name":"DHEA sulfate","score":0.8650000095367432},{"id":"https://openalex.org/keywords/well-being","display_name":"well-being","score":0.8420000076293945},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.7839999794960022},{"id":"https://openalex.org/keywords/placebo-effect","display_name":"placebo effect","score":0.7490000128746033},{"id":"https://openalex.org/keywords/subjective-symptoms","display_name":"subjective symptoms","score":0.4650000035762787},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6290000081062317},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cognitive-behavioral-therapy","display_name":"cognitive behavioral therapy","score":0.6850000023841858},{"id":"https://openalex.org/keywords/adrenal-hormones","display_name":"adrenal hormones","score":0.546999990940094},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7908580303192139},{"id":"https://openalex.org/C2779566273","wikidata":"https://www.wikidata.org/wiki/Q209733","display_name":"Chronic fatigue syndrome","level":2,"score":0.7097899913787842},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.7059091925621033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6307491064071655},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5746481418609619},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5094714760780334},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4558523893356323},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4500109851360321},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.4190395474433899},{"id":"https://openalex.org/C2777031586","wikidata":"https://www.wikidata.org/wiki/Q131749","display_name":"Anorexia nervosa","level":3,"score":0.41748136281967163},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.4121948480606079},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.40639764070510864},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.27354615926742554},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24461087584495544},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15539300441741943},{"id":"https://openalex.org/C2776394216","wikidata":"https://www.wikidata.org/wiki/Q373822","display_name":"Eating disorders","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/299917","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/299917","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/299917","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/299917","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/299917","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/299917","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:608628564","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/1874/299917/1/hartkamp.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/299917","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/299917","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W3008177","https://openalex.org/W63743305","https://openalex.org/W73999194","https://openalex.org/W99378873","https://openalex.org/W110953900","https://openalex.org/W120212396","https://openalex.org/W126866256","https://openalex.org/W151453973","https://openalex.org/W172676584","https://openalex.org/W614531583","https://openalex.org/W1495995879","https://openalex.org/W1525187255","https://openalex.org/W1537631996","https://openalex.org/W1592959032","https://openalex.org/W1824111805","https://openalex.org/W1826489341","https://openalex.org/W1871029534","https://openalex.org/W1875064638","https://openalex.org/W1890791367","https://openalex.org/W1922088893","https://openalex.org/W1930926117","https://openalex.org/W1965952042","https://openalex.org/W1968899278","https://openalex.org/W1969503589","https://openalex.org/W1970025509","https://openalex.org/W1971345242","https://openalex.org/W1974195695","https://openalex.org/W1978912458","https://openalex.org/W1986029976","https://openalex.org/W1992072556","https://openalex.org/W1995936060","https://openalex.org/W1997807118","https://openalex.org/W2003239266","https://openalex.org/W2005432482","https://openalex.org/W2005656145","https://openalex.org/W2006747562","https://openalex.org/W2009794436","https://openalex.org/W2012980964","https://openalex.org/W2013667866","https://openalex.org/W2014713032","https://openalex.org/W2021723318","https://openalex.org/W2022970599","https://openalex.org/W2025227305","https://openalex.org/W2025516095","https://openalex.org/W2025948881","https://openalex.org/W2032491522","https://openalex.org/W2035947631","https://openalex.org/W2037166637","https://openalex.org/W2038169210","https://openalex.org/W2039514754","https://openalex.org/W2045402270","https://openalex.org/W2048547196","https://openalex.org/W2052504531","https://openalex.org/W2056930167","https://openalex.org/W2065529690","https://openalex.org/W2068439980","https://openalex.org/W2070207717","https://openalex.org/W2073650658","https://openalex.org/W2074569521","https://openalex.org/W2074953761","https://openalex.org/W2079279434","https://openalex.org/W2079611807","https://openalex.org/W2085116286","https://openalex.org/W2085759552","https://openalex.org/W2085954924","https://openalex.org/W2087484885","https://openalex.org/W2087740801","https://openalex.org/W2090975241","https://openalex.org/W2094694548","https://openalex.org/W2098007542","https://openalex.org/W2103067426","https://openalex.org/W2104594053","https://openalex.org/W2105331461","https://openalex.org/W2111859264","https://openalex.org/W2113314714","https://openalex.org/W2117480041","https://openalex.org/W2120713232","https://openalex.org/W2121174488","https://openalex.org/W2125439077","https://openalex.org/W2130095506","https://openalex.org/W2134829737","https://openalex.org/W2136811290","https://openalex.org/W2138758697","https://openalex.org/W2142820105","https://openalex.org/W2146789264","https://openalex.org/W2151093863","https://openalex.org/W2165211289","https://openalex.org/W2167385753","https://openalex.org/W2167497163","https://openalex.org/W2170332928","https://openalex.org/W2172287852","https://openalex.org/W2215806678","https://openalex.org/W2253364553","https://openalex.org/W2321306700","https://openalex.org/W2324268873","https://openalex.org/W2328771548","https://openalex.org/W2399315936","https://openalex.org/W2413863715","https://openalex.org/W2416910035","https://openalex.org/W2419091689","https://openalex.org/W2464525413","https://openalex.org/W2467637424","https://openalex.org/W2587926148"],"related_works":["https://openalex.org/W2104594053","https://openalex.org/W2467637424","https://openalex.org/W2335416205","https://openalex.org/W2025227305","https://openalex.org/W2079611807","https://openalex.org/W2121174488","https://openalex.org/W4295539249","https://openalex.org/W2120713232","https://openalex.org/W2006747562","https://openalex.org/W2116468155"],"abstract_inverted_index":{"Fatigue":[0],"is":[1,86],"a":[2,27,87,192,327],"prevalent":[3],"and":[4,19,41,73,105,122,140,147,153,172,174,180,189,208,216,229,233,243,261,274,282,321,334,336,370,376],"debilitating":[5],"symptom":[6],"in":[7,57,75,131,176,182,191,241,272,277,289,326,346,349,351,372],"patients":[8,76,132,144,213,245,269,290,331,373],"with":[9,133,145,178,214,302,310,332,374],"the":[10,37,54,90,97,165,197,303,338,341,386],"chronic":[11,137],"inflammatory":[12],"autoimmune":[13],"diseases":[14,25],"primary":[15],"Sj\u00f6gren\u2019s":[16],"syndrome":[17,139],"(pSS)":[18],"systemic":[20],"lupus":[21],"erythematosus":[22],"(SLE).":[23],"Both":[24],"have":[26,127,306],"female":[28,186],"preponderance":[29],"(women":[30],"to":[31,47,61,114,184,220,250,268,305,367],"men":[32],"ratio":[33],"9:1).":[34],"Doctors":[35],"recognize":[36],"existence":[38],"of":[39,53,65,112,151,199,201,265,280,296,319,330,340,343,365,388],"fatigue":[40,138,173,281,297,320,369],"its":[42,154,311],"consequences,":[43],"but":[44],"are":[45,160],"unable":[46],"treat":[48],"it.":[49],"The":[50,81,294],"main":[51],"objective":[52],"studies":[55,108,315,360,384],"described":[56,130],"this":[58],"thesis":[59,163],"was":[60,254,298],"study":[62,196],"whether":[63],"administration":[64,111,200],"DHEA":[66,85,113,152,202,267,308,366],"has":[67],"positive":[68,125],"effects":[69,126,198,286,387],"on":[70,205,353,385],"fatigue,":[71,123,206,226],"well-being":[72,175,232,322,371],"functioning":[74],"suffering":[77],"from":[78,89],"these":[79,262],"conditions.":[80],"weak":[82],"androgenic":[83],"hormone":[84],"product":[88],"human":[91],"adrenal":[92],"glands.":[93],"In":[94,143,378],"peripheral":[95],"tissues,":[96],"compound":[98],"can":[99,117,323],"be":[100,324],"converted":[101],"into":[102],"active":[103],"androgens":[104],"estrogens.":[106],"Several":[107],"reported":[109],"that":[110,212,317],"elderly":[115],"people":[116],"improve":[118],"age-related":[119],"decreased":[120],"vitality":[121],"whereas":[124],"also":[128],"been":[129],"depression,":[134],"anorexia":[135],"nervosa,":[136],"Addison\u2019s":[141],"disease.":[142],"pSS":[146,179,215,242,273,335,375],"SLE,":[148],"serum":[149,170,239],"levels":[150,171,240],"sulphate":[155],"ester":[156],"DHEAS":[157],"not":[158,362],"infrequently":[159],"decreased.":[161],"This":[162],"evaluated":[164],"association":[166],"between":[167,258],"endogenous":[168],"DHEA-S":[169,238,259],"women":[177],"SLE":[181,217,244,275,333],"comparison":[183],"healthy":[185,221,251],"age-matched":[187],"controls":[188],"examined":[190],"randomized":[193],"double-blind":[194],"placebo-controlled":[195],"200":[203],"mg/day":[204],"well-being,":[207],"functioning.":[209,235],"We":[210],"found":[211,288],"report,":[218],"compared":[219,249],"controls,":[222,252],"far":[223],"more":[224,300],"general":[225],"depressed":[227],"mood":[228],"reduced":[230,325],"mental":[231],"physical":[234],"However,":[236,284],"although":[237],"were":[246,287],"significantly":[247],"lower":[248],"there":[253],"no":[255],"significant":[256,278,328],"correlation":[257],"level":[260],"manifestations.":[263],"Administration":[264],"exogenous":[266],"resulted,":[270],"both":[271],"patients,":[276],"improvement":[279,295],"well-being.":[283],"similar":[285],"who":[291],"received":[292],"placebo.":[293],"associated":[299],"strongly":[301],"belief":[304],"used":[307],"than":[309],"actual":[312],"use.":[313],"Our":[314],"indicate":[316],"complaints":[318],"number":[329],"illustrate":[337],"importance":[339],"inclusion":[342],"placebo":[344],"groups":[345],"clinical":[347],"studies,":[348],"particular":[350],"those":[352],"subjective":[354],"manifestations":[355],"like":[356],"fatigue.":[357],"Unfortunately,":[358],"our":[359,380],"do":[361],"support":[363,382],"use":[364],"influence":[368],"SLE.":[377],"contrast,":[379],"results":[381],"future":[383],"cognitive":[389],"behavioral":[390],"therapy.":[391]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
