{"id":"https://openalex.org/W608354086","doi":null,"title":"Handbook of Pharmaceutical Biotechnology","display_name":"Handbook of Pharmaceutical Biotechnology","publication_year":2003,"publication_date":"2003-03-31","ids":{"openalex":"https://openalex.org/W608354086","mag":"608354086"},"language":"en","primary_location":{"id":"mag:608354086","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/ncid/BA74525627","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"book","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002462952","display_name":"Stan G. Louie","orcid":"https://orcid.org/0000-0001-5941-6690","observed_orcids":["https://orcid.org/0000-0001-5941-6690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stan G. Louie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5941-6690","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108248447","display_name":"Rho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004440779","display_name":"Jay P. Rho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay P. Rho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3016,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63473054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.17589999735355377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.17479999363422394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmaceutical-biotechnology","display_name":"pharmaceutical biotechnology","score":0.9210000038146973},{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.9049999713897705},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hybridoma-technology","display_name":"hybridoma technology","score":0.7269999980926514},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.6970000267028809},{"id":"https://openalex.org/keywords/factor-ix","display_name":"factor IX","score":0.8080000281333923},{"id":"https://openalex.org/keywords/thrombolytic-enzymes","display_name":"thrombolytic enzymes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7720000147819519},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.753000020980835},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.9279999732971191},{"id":"https://openalex.org/keywords/colony-stimulating-factors","display_name":"colony-stimulating factors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8489999771118164},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9629999995231628},{"id":"https://openalex.org/keywords/oligonucleotide-therapeutics","display_name":"oligonucleotide therapeutics","score":0.9160000085830688},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.699999988079071},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/gene-delivery-systems","display_name":"gene delivery systems","score":0.843999981880188},{"id":"https://openalex.org/keywords/antisense-therapy","display_name":"antisense therapy","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5734773278236389},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.517268717288971},{"id":"https://openalex.org/C2780790693","wikidata":"https://www.wikidata.org/wiki/Q3933703","display_name":"Reteplase","level":4,"score":0.4181448221206665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4114590883255005},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36768102645874023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3370811939239502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29053109884262085},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17369255423545837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10559457540512085},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08048641681671143},{"id":"https://openalex.org/C2776336681","wikidata":"https://www.wikidata.org/wiki/Q416485","display_name":"Streptokinase","level":3,"score":0.07216763496398926},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:608354086","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/ncid/BA74525627","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W296016125","https://openalex.org/W2038052242","https://openalex.org/W2996078914","https://openalex.org/W589242123","https://openalex.org/W1863802532","https://openalex.org/W1992629832","https://openalex.org/W1524733670","https://openalex.org/W2087069281","https://openalex.org/W598828149","https://openalex.org/W643567337"],"abstract_inverted_index":{"*":[0,4,6,12,20,25,30,33,36,41,43,46,49,52,55,58,61,64,69,71,76,79,84,89,98,103,112,114,117,120,122,124,128,138,140,143,145,147,150,155,159,161,165,171,178,185,187,190,193,197,204,210,212,214],"About":[1],"the":[2],"Editors":[3],"Contributors":[5],"Chapter":[7,37,65,104,129,156,179],"1.":[8],"Introduction":[9,42,70,113,139,160,186],"to":[10],"Biotechnology":[11],"Delivery":[13,195],"of":[14,27,109],"Recombinant":[15,28,72],"DNA":[16],"into":[17],"Expression":[18,23],"Vectors":[19],"Host":[21],"or":[22],"Cells":[24],"Development":[26],"Protein":[29,177],"Hybridoma":[31],"Technology":[32],"Chimerization":[34],"Process":[35],"2.":[38],"Monoclonal":[39],"Antibodies":[40],"Abciximab":[44],"(Reopro(R))":[45],"Muromonab-CD3":[47],"(Orthoclone(R))":[48],"Basiliximab":[50],"(Simulect(R))":[51],"Daclizumab":[53],"(Zenapax(R))":[54],"Rituximab":[56],"(Rituxan(R))":[57],"Trastuzumab":[59],"(Herceptin(R))":[60],"Palivizumab":[62],"(Synagis(R))":[63],"3.":[66],"Clotting":[67],"Factors":[68,149],"Factor":[73,77,81,86,93,99,153,168],"VIII":[74,78],"(NovoSeven(R))":[75],"Antihemophilic":[80,85],"(Recombinant)":[82,87],"(Recombinate(t))":[83],"(Kogenate(R))":[88],"Recombinant,":[90],"B-Domain":[91],"Deleted":[92],"VIII,":[94],"r-FVIII":[95],"SQ":[96],"(Refacto(R))":[97],"IX":[100],"rFIX":[101],"(Benefix(R))":[102],"4.":[105],"Enzymes":[106],"and":[107,135,182],"Regulators":[108],"Enzyme":[110],"Activity":[111],"Alteplase":[115],"(Activase(R))":[116],"Reteplase":[118],"(Retavase(R))":[119],"Lanoteplase":[121],"Tenecteplase":[123],"Dornase":[125],"Alfa":[126],"(Pulmozyme(R))":[127],"5.":[130],"Cytokines":[131],"(Stan":[132],"G.":[133],"Louie":[134],"Parul":[136],"Patel)":[137],"Interleukin":[141],"2":[142],"Interleukin-11":[144],"Interferons":[146],"Colony-Stimulating":[148],"Platelet-Derived":[151],"Growth":[152],"BB":[154],"6.":[157],"Anticytokines":[158],"Interleukin-1":[162],"Receptor":[163,170,174],"Antagonist":[164],"Tumor":[166],"Necrosis":[167],"Soluble":[169,173],"TNF-":[172],"p55-IgG1":[175],"Fusion":[176],"7.":[180],"Oligonucleotide":[181,188],"Gene":[183,194,202,208],"Therapy":[184,189,192,203,209],"ras-Antisense":[191],"Systems":[196],"Current":[198],"Strategies":[199],"for":[200],"Cancer":[201],"Clinical":[205],"Trials":[206],"with":[207],"Conclusion":[211],"Index":[213],"Reference":[215],"Notes":[216],"Included":[217]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2016-06-24T00:00:00"}
