{"id":"https://openalex.org/W607942418","doi":"https://doi.org/10.34429/00002834","title":"Effects of Sirtinol on Early Development of the Cloned Murine Embryos","display_name":"Effects of Sirtinol on Early Development of the Cloned Murine Embryos","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W607942418","doi":"https://doi.org/10.34429/00002834","mag":"607942418"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:00842:0004398047","doi":"https://doi.org/10.34429/00002834","is_oa":true,"landing_page_url":"https://yamanashi.repo.nii.ac.jp/records/2841","pdf_url":"https://yamanashi.repo.nii.ac.jp/record/2841/files/AA11839837_23_04_02.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yamanashi medical journal","raw_type":"journal article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://yamanashi.repo.nii.ac.jp/record/2841/files/AA11839837_23_04_02.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084672132","display_name":"Shuji Hirata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuji Hirata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058491622","display_name":"Hiroko Fukasawa","orcid":"https://orcid.org/0000-0003-1723-8130","observed_orcids":["https://orcid.org/0000-0003-1723-8130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Fukasawa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1723-8130","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045722604","display_name":"Hikaru Tagaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hikaru Tagaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011856113","display_name":"Tomoko Shoda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoko Shoda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033838383","display_name":"Teruhiko Wakayama","orcid":"https://orcid.org/0000-0002-6151-2603","observed_orcids":["https://orcid.org/0000-0002-6151-2603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teruhiko Wakayama","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6151-2603","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103635166","display_name":"Kazuhiko Hoshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhiko Hoshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4539,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62039294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"23","issue":"4","first_page":"97","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirtinol","display_name":"sirtinol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/somatic-cell-nuclear-transfer","display_name":"somatic cell nuclear transfer","score":0.890999972820282},{"id":"https://openalex.org/keywords/cloned-embryos","display_name":"cloned embryos","score":0.7749999761581421},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6060000061988831},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.828000009059906},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.949999988079071},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.8809999823570251},{"id":"https://openalex.org/keywords/embryo-activation","display_name":"embryo activation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/mouse-cloning","display_name":"mouse cloning","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.7847090363502502},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.7693583965301514},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.685934841632843},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.6221103072166443},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5272166728973389},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.45696821808815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43206995725631714},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3373536169528961},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32918721437454224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18632930517196655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12104883790016174},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0685172975063324},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:00842:0004398047","doi":"https://doi.org/10.34429/00002834","is_oa":true,"landing_page_url":"https://yamanashi.repo.nii.ac.jp/records/2841","pdf_url":"https://yamanashi.repo.nii.ac.jp/record/2841/files/AA11839837_23_04_02.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yamanashi medical journal","raw_type":"journal article"},{"id":"mag:607942418","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/110007018284","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00842:0004398047","doi":"https://doi.org/10.34429/00002834","is_oa":true,"landing_page_url":"https://yamanashi.repo.nii.ac.jp/records/2841","pdf_url":"https://yamanashi.repo.nii.ac.jp/record/2841/files/AA11839837_23_04_02.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yamanashi medical journal","raw_type":"journal article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W607942418.pdf","grobid_xml":"https://content.openalex.org/works/W607942418.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1487014009","https://openalex.org/W1979933737","https://openalex.org/W1987738803","https://openalex.org/W1995539279","https://openalex.org/W2000091990","https://openalex.org/W2018221132","https://openalex.org/W2031954417","https://openalex.org/W2047220698","https://openalex.org/W2054314939","https://openalex.org/W2084162879","https://openalex.org/W2093155802","https://openalex.org/W2102635586","https://openalex.org/W2135243105","https://openalex.org/W2187842058"],"related_works":["https://openalex.org/W2067373594","https://openalex.org/W2042331003","https://openalex.org/W7099904196","https://openalex.org/W1998202420","https://openalex.org/W2405235593","https://openalex.org/W2093155802","https://openalex.org/W2058056241","https://openalex.org/W2590153988","https://openalex.org/W2756996074","https://openalex.org/W2074781740"],"abstract_inverted_index":{"Since":[0],"1996,":[1],"when":[2],"Dolly":[3],"was":[4,133],"born,":[5],"cloned":[6,77,102,157,178],"vertebrates":[7],"have":[8,84],"been":[9,69],"produced":[10],"in":[11,26,35],"many":[12],"species.":[13],"However,":[14],"the":[15,36,47,58,74,80,86,97,156,174],"success":[16],"rate":[17,30,129],"of":[18,38,44,49,57,76,88,100,130,155,177],"animal":[19,39],"cloning":[20,40],"has":[21,68],"remained":[22],"very":[23],"low":[24,29],"especially":[25],"mice.":[27,78],"This":[28],"is":[31],"a":[32,101],"severe":[33],"hindrance":[34],"application":[37],"on":[41,96,184],"various":[42],"fields":[43],"studies.":[45],"Recently,":[46],"treatment":[48,137],"reconstructed":[50,107],"embryos":[51,180],"with":[52,108,118,138,162],"trichostatin":[53],"A":[54],"(TSA),":[55],"one":[56],"inhibitors":[59],"for":[60,92,123,142],"classes":[61],"I":[62],"and":[63,112,164],"II":[64],"histone":[65],"deacetylases":[66],"(HDACs),":[67],"reported":[70],"to":[71],"significantly":[72,134],"improve":[73],"development":[75,99,176],"In":[79],"present":[81],"study,":[82],"we":[83],"investigated":[85],"effect":[87],"sirtinol,":[89,165],"an":[90,109],"inhibitor":[91],"class":[93],"III":[94],"HDAC,":[95],"early":[98,175],"murine":[103,179],"embryos.":[104],"The":[105,128],"embryos,":[106,158],"enucleated":[110],"oocyte":[111],"cumulus":[113],"cell":[114],"nucleus,":[115],"were":[116,151,160],"treated":[117,161],"sirtinol":[119,141,172],"during":[120],"activation":[121],"and/or":[122],"12":[124,143],"hr":[125,144],"after":[126,145,153],"activation.":[127,146],"blastocyst":[131],"formation":[132],"improved":[135],"by":[136],"100":[139],"\u03bcM":[140],"Moreover,":[147],"six":[148],"live":[149],"offspring":[150],"born":[152],"transfer":[154],"which":[159],"TSA":[163],"into":[166],"surrogate":[167],"mothers.":[168],"These":[169],"resultsindicate":[170],"that":[171],"improves":[173],"without":[181],"adverse":[182],"effects":[183],"subsequent":[185],"development.":[186]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}