{"id":"https://openalex.org/W60688671","doi":null,"title":"[Sulphur amino acids, vitamin B12 and folic acid in children with chronic renal failure].","display_name":"[Sulphur amino acids, vitamin B12 and folic acid in children with chronic renal failure].","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W60688671","mag":"60688671","pmid":"https://pubmed.ncbi.nlm.nih.gov/10897644"},"language":"pl","primary_location":{"id":"pmid:10897644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10897644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065022925","display_name":"Mieczys\u0142aw Litwin","orcid":"https://orcid.org/0000-0002-5241-2483","observed_orcids":["https://orcid.org/0000-0002-5241-2483"]},"institutions":[{"id":"https://openalex.org/I4210114383","display_name":"Children's Memorial Health Institute","ror":"https://ror.org/020atbp69","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210114383"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M Litwin","raw_affiliation_strings":["Kliniki Dializoterapii i Transplantacji Nerek, Instytut-Pomnik Centrum Zdrowia Dziecka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kliniki Dializoterapii i Transplantacji Nerek, Instytut-Pomnik Centrum Zdrowia Dziecka","institution_ids":["https://openalex.org/I4210114383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012551207","display_name":"Mahmoud Abuauba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Abuauba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031224719","display_name":"Zbigniew T. Wawer","orcid":"https://orcid.org/0000-0002-8866-4578","observed_orcids":["https://orcid.org/0000-0002-8866-4578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z T Wawer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032575345","display_name":"Ryszard Grenda","orcid":"https://orcid.org/0000-0002-6814-6589","observed_orcids":["https://orcid.org/0000-0002-6814-6589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Grenda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065950381","display_name":"Tomasz Kury\u0142","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kury\u0142","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110048961","display_name":"Ewa Pietraszek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Pietraszek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8018,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71470173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"46","first_page":"268","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sulphur-amino-acids","display_name":"sulphur amino acids","score":0.8550000190734863},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serine","display_name":"serine","score":0.996999979019165},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.8579999804496765},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":1.0},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.734000027179718},{"id":"https://openalex.org/keywords/plasma-amino-acid-profile","display_name":"plasma amino acid profile","score":0.7670000195503235},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.3799999952316284},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.5080000162124634},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.5649999976158142},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.7889999747276306},{"id":"https://openalex.org/keywords/uremic-toxins","display_name":"uremic toxins","score":0.49900001287460327},{"id":"https://openalex.org/keywords/uremic-prerenal-syndrome","display_name":"uremic prerenal syndrome","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6384342908859253},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6209648847579956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5676171183586121},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.5284968018531799},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.5225350856781006},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49802231788635254},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4508377015590668},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4492012858390808},{"id":"https://openalex.org/C2780678043","wikidata":"https://www.wikidata.org/wiki/Q743241","display_name":"Group A","level":2,"score":0.4381939470767975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38246822357177734},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.34830087423324585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3133586049079895}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000603","descriptor_name":"Amino Acids, Sulfur","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000603","descriptor_name":"Amino Acids, Sulfur","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D020138","descriptor_name":"Hyperhomocysteinemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10897644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10897644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego","raw_type":"English Abstract"},{"id":"mag:60688671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10897644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987092724","https://openalex.org/W2382185862","https://openalex.org/W2059440411","https://openalex.org/W2352979586","https://openalex.org/W2082022423","https://openalex.org/W2062956590","https://openalex.org/W332806224","https://openalex.org/W2062472178","https://openalex.org/W2049489625","https://openalex.org/W2952263175"],"abstract_inverted_index":{"UNLABELLED:":[0],"Aim":[1],"of":[2,11,192,212,285,306],"the":[3,101,122],"study":[4],"was":[5,151],"to:":[6],"1)":[7,178,198,219],"estimate":[8],"plasma":[9,72,304],"profile":[10],"sulphur":[12,236,307],"AA":[13,237],"in":[14,22,103,128,148,171,253,277],"children":[15,23],"with":[16,33,44,47,56,83,249,303],"chronic":[17],"renal":[18],"failure":[19],"(CRF)":[20],"and":[21,27,38,64,88,113,137,159,184,204,225,238,240,255,268,287,293,299],"on":[24,67,282],"hemodialysis":[25],"(HD),":[26],"2)":[28,112,136,183,203,224],"to":[29],"evaluate":[30],"any":[31],"correlation":[32,234],"serum":[34],"folic":[35],"acid":[36],"(FA)":[37],"vitamin":[39],"B12.":[40],"PATIENTS:":[41],"32":[42],"pts":[43,66,248,281],"CRF:":[45],"9":[46,55,109],"GFR":[48,57,269],">":[49],"20":[50,59,114],"ml/min/1.73":[51,60],"m2":[52,61],"(group":[53,62,69,111,116,135,140,157,162,177,182,187,197,202,207,218,223,228],"1),":[54],"<":[58,266,271],"2),":[63,158],"14":[65],"HD":[68,283],"3).":[70,188],"METHODS:":[71],"homocysteine":[73],"(Hcys),":[74],"methionine":[75],"(Met),":[76],"cysteine":[77],"(Cys),":[78],"serine":[79],"(Ser)":[80],"were":[81,91,100,126,169,194,215,232],"measured":[82,92],"gas":[84],"chromatography.":[85],"Serum":[86],"FA":[87,193,239,292],"vit.":[89,213,241,294],"B12":[90,214,242,295],"using":[93],"MEIA":[94],"method.":[95],"RESULTS:":[96],"median":[97,172,190],"Hcys":[98,250],"concentrations":[99,191,211,296,305],"lowest":[102,123],"group":[104,129,149],"1:":[105],"5":[106],"mumol/l":[107,110,115,134,139,153,156,161,176,181,186],"vs":[108,132,154,179,199,220,262],"3)":[117,141,163,208,229],"(p":[118,142,164,270],"=":[119,143,165],"0.03).":[120],"Similarly,":[121],"Met":[124,259,286],"levels":[125,251,284],"observed":[127],"1--26":[130],"mumol/l,":[131,264],"66":[133],"281":[138],"0.001).":[144],"Median":[145,210],"Cys":[146,288],"level":[147],"1":[150],"98":[152],"54":[155],"122":[160],"0.02).":[166],"No":[167],"differences":[168],"found":[170],"Ser":[173],"levels:":[174],"153":[175],"239":[180],"240":[185],"The":[189,244],"6.3":[195],"ng/ml":[196,201,206],"8":[200],"15":[205],"(NS).":[209,230],"256":[216],"pg/ml":[217,222,227],"379":[221],"322":[226],"There":[231],"no":[233],"between":[235,247],"levels.":[243],"only":[245],"difference":[246],"remaining":[252],"lower":[254],"upper":[256],"quartile":[257],"concerned":[258],"concentration":[260],"(38":[261],"263":[263],"p":[265],"0.02)":[267],"0.01).":[272],"CONCLUSIONS:":[273],"Hyperhomocysteinemia":[274],"develops":[275],"already":[276],"moderate":[278],"CRF.":[279],"In":[280],"are":[289,297],"also":[290],"raised.":[291],"normal":[298],"do":[300],"not":[301],"correlate":[302],"AA.":[308]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}