{"id":"https://openalex.org/W605803817","doi":null,"title":"Phosphorylation of Histone Deacetylase 6 within its C-terminal Region by Extracellular Signal Regulated Kinase 1","display_name":"Phosphorylation of Histone Deacetylase 6 within its C-terminal Region by Extracellular Signal Regulated Kinase 1","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W605803817","mag":"605803817"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-5989","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/4792","pdf_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5989&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5989&context=etd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015095741","display_name":"Kendra A. Williams","orcid":"https://orcid.org/0009-0001-1711-7622","observed_orcids":["https://orcid.org/0009-0001-1711-7622"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kendra A. Williams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015095741"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":0.9330000281333923},{"id":"https://openalex.org/keywords/erk1","display_name":"ERK1","score":0.753000020980835},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/c-terminal-region","display_name":"C-terminal region","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9020000100135803},{"id":"https://openalex.org/keywords/deacetylation","display_name":"deacetylation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tubulin-deacetylation","display_name":"tubulin deacetylation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cortactin","display_name":"cortactin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7160000205039978},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C23681527","wikidata":"https://www.wikidata.org/wiki/Q18034953","display_name":"HDAC6","level":5,"score":0.7758168578147888},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7145048975944519},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6284267902374268},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5993527770042419},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.543657660484314},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5424538254737854},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.504289984703064},{"id":"https://openalex.org/C142354902","wikidata":"https://www.wikidata.org/wiki/Q18047334","display_name":"HDAC10","level":5,"score":0.46465033292770386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42767518758773804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42310789227485657},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3393508791923523},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3370336890220642},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3012459874153137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2990504503250122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:digitalcommons.usf.edu:etd-5989","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/4792","pdf_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5989&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"pmh:oai:scholarcommons.usf.edu:etd-5989","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/4792","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=5989&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"pmh:oai:pqdtoai.proquest.com:3590299","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3590299","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3590299","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"mag:605803817","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5989&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-5989","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/4792","pdf_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=5989&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W605803817.pdf","grobid_xml":"https://content.openalex.org/works/W605803817.grobid-xml"},"referenced_works_count":135,"referenced_works":["https://openalex.org/W18353697","https://openalex.org/W140287985","https://openalex.org/W154704142","https://openalex.org/W1507957953","https://openalex.org/W1567485746","https://openalex.org/W1578523240","https://openalex.org/W1590355453","https://openalex.org/W1718435705","https://openalex.org/W1821277660","https://openalex.org/W1896007356","https://openalex.org/W1964017399","https://openalex.org/W1967100876","https://openalex.org/W1967400782","https://openalex.org/W1970512343","https://openalex.org/W1970527559","https://openalex.org/W1972149587","https://openalex.org/W1973642840","https://openalex.org/W1973962086","https://openalex.org/W1975692560","https://openalex.org/W1978810723","https://openalex.org/W1979832500","https://openalex.org/W1984720025","https://openalex.org/W1985990006","https://openalex.org/W1986753065","https://openalex.org/W1987366741","https://openalex.org/W1987769201","https://openalex.org/W1989819921","https://openalex.org/W1990011854","https://openalex.org/W1990348210","https://openalex.org/W1992027492","https://openalex.org/W1993077125","https://openalex.org/W1993243592","https://openalex.org/W1994556689","https://openalex.org/W1994659747","https://openalex.org/W1995536179","https://openalex.org/W1998499089","https://openalex.org/W1999720300","https://openalex.org/W1999931286","https://openalex.org/W2002404925","https://openalex.org/W2004800205","https://openalex.org/W2006419043","https://openalex.org/W2006466204","https://openalex.org/W2009590302","https://openalex.org/W2009826707","https://openalex.org/W2010022150","https://openalex.org/W2011826559","https://openalex.org/W2016167871","https://openalex.org/W2016360721","https://openalex.org/W2017410521","https://openalex.org/W2020484263","https://openalex.org/W2021369251","https://openalex.org/W2021536610","https://openalex.org/W2030185116","https://openalex.org/W2033559279","https://openalex.org/W2033799985","https://openalex.org/W2036256995","https://openalex.org/W2036999913","https://openalex.org/W2037793441","https://openalex.org/W2038568403","https://openalex.org/W2040196938","https://openalex.org/W2040942754","https://openalex.org/W2041827225","https://openalex.org/W2041963587","https://openalex.org/W2045696025","https://openalex.org/W2046316599","https://openalex.org/W2047809719","https://openalex.org/W2049225918","https://openalex.org/W2050748595","https://openalex.org/W2052131847","https://openalex.org/W2055380229","https://openalex.org/W2062289724","https://openalex.org/W2064959533","https://openalex.org/W2065571115","https://openalex.org/W2067297743","https://openalex.org/W2068257081","https://openalex.org/W2070089404","https://openalex.org/W2070334890","https://openalex.org/W2071715575","https://openalex.org/W2073978750","https://openalex.org/W2074687765","https://openalex.org/W2076614498","https://openalex.org/W2084343793","https://openalex.org/W2087252788","https://openalex.org/W2087650843","https://openalex.org/W2087961967","https://openalex.org/W2087966689","https://openalex.org/W2090381051","https://openalex.org/W2090786177","https://openalex.org/W2094159326","https://openalex.org/W2094464106","https://openalex.org/W2097360510","https://openalex.org/W2098688944","https://openalex.org/W2101127235","https://openalex.org/W2102650381","https://openalex.org/W2105804718","https://openalex.org/W2107495112","https://openalex.org/W2107733280","https://openalex.org/W2110787699","https://openalex.org/W2114579003","https://openalex.org/W2114819889","https://openalex.org/W2115134500","https://openalex.org/W2116146392","https://openalex.org/W2117298794","https://openalex.org/W2121296685","https://openalex.org/W2123032057","https://openalex.org/W2124008135","https://openalex.org/W2125568224","https://openalex.org/W2128151020","https://openalex.org/W2128761802","https://openalex.org/W2130473918","https://openalex.org/W2133801172","https://openalex.org/W2135830745","https://openalex.org/W2138231208","https://openalex.org/W2144796426","https://openalex.org/W2146620343","https://openalex.org/W2146671895","https://openalex.org/W2148294117","https://openalex.org/W2148495272","https://openalex.org/W2149379768","https://openalex.org/W2149555430","https://openalex.org/W2150171625","https://openalex.org/W2151445954","https://openalex.org/W2151833757","https://openalex.org/W2155045727","https://openalex.org/W2156363416","https://openalex.org/W2159594827","https://openalex.org/W2159770815","https://openalex.org/W2164763417","https://openalex.org/W2166753481","https://openalex.org/W2167118090","https://openalex.org/W2167546942","https://openalex.org/W2168448928","https://openalex.org/W2168491902","https://openalex.org/W2170411990","https://openalex.org/W2764697923"],"related_works":["https://openalex.org/W1994224177","https://openalex.org/W2778615271","https://openalex.org/W2741660838","https://openalex.org/W2763366864","https://openalex.org/W2021369251","https://openalex.org/W2119133472","https://openalex.org/W7007923058","https://openalex.org/W2090786177","https://openalex.org/W110225692","https://openalex.org/W3200164063"],"abstract_inverted_index":{"Reversible":[0],"acetylation":[1,171],"regulated":[2,163,200],"by":[3,22,164,212,294,323,438],"histone":[4,8,28],"acetyltransferases":[5],"(HATs)":[6],"and":[7,46,52,75,85,120,147,172,185,237,266,300,311,383,440,466],"deacetylases":[9],"(HDACs)":[10],"plays":[11,285],"a":[12,89,116,131,149,208,220,230,278,286,419,430,455],"major":[13,209,231,279,456],"role":[14,288],"in":[15,33,107,223,233,289,306,309,312,416],"transcriptional":[16,20,39],"regulation.":[17],"HATs":[18,45],"promote":[19,155,255,397,447],"activation":[21,330],"adding":[23],"acetyl":[24],"groups":[25],"to":[26,38,43,96,154,241,254,380,396],"the":[27,34,103,188,332,401,408,451],"tails,":[29],"while":[30,205],"HDACs":[31,47],"act":[32],"reverse":[35],"process":[36],"leading":[37],"repression.":[40],"In":[41,325,422],"addition":[42],"histones,":[44],"also":[48,162,239,413],"modify":[49],"numerous":[50,459],"proteins,":[51],"therefore":[53],"affect":[54,363],"many":[55,126],"biological":[56],"processes.":[57],"The":[58],"HDAC":[59,104],"family":[60,105],"consists":[61],"of":[62,134,190,275,282,297,319,331,348,356,373,387,444,458,463],"18":[63],"members,":[64],"which":[65,94,434],"are":[66,194],"grouped":[67],"into":[68,82],"four":[69],"classes,":[70],"namely":[71],"I,":[72],"II,":[73],"III":[74],"IV,":[76],"with":[77],"class":[78,97],"II":[79],"further":[80],"subdivided":[81],"subclass":[83],"IIa":[84],"IIb.":[86,98],"HDAC6":[87,99,129,136,160,226,253,276,283,302,320,341,349,357,364,374,388,412,427,445,467],"is":[88,100,137,152,161,207,277,321,454],"predominantly":[90],"localized":[91],"cytoplasmic":[92,117,144],"deacetylase,":[93],"belongs":[95],"unique":[101],"among":[102],"members":[106],"that":[108,151,272,284,317,329,354,411],"it":[109],"expresses":[110],"two":[111],"complete":[112],"functional":[113],"deacetylase":[114,141],"domains,":[115],"anchoring":[118],"motif,":[119,204],"an":[121,197],"ubiquitin":[122],"binding":[123],"domain.":[124],"Like":[125],"other":[127],"HDACs,":[128],"has":[130],"growing":[132],"list":[133],"substrates.":[135],"known":[138,153],"for":[139,244,407,471],"its":[140,298,394],"activity":[142,366],"towards":[143,367],"proteins":[145],"\u03b1-tubulin":[146,382],"cortactin,":[148],"function":[150],"HDAC6-":[156],"mediated":[157],"cell":[158,235,256,292,304,398,402,448],"migration.":[159,449],"post":[165],"translational":[166],"modifications":[167],"such":[168],"as,":[169],"phosphorylation,":[170],"ubiquitination.":[173],"Using":[174,308],"mass":[175],"spectrometric":[176],"analysis,":[177],"we":[178,270,315,327,352],"have":[179,216,258],"identified":[180,217,228,426],"additional":[181],"phosphorylation":[182,280,432,442],"sites,":[183],"Threonine-1031":[184],"Serine-1035,":[186],"within":[187,196],"C-terminal":[189],"HDAC6.":[191],"Both":[192],"sites":[193],"located":[195],"extracellular":[198],"signal":[199],"kinase":[201,336],"(ERK)":[202],"recognition":[203],"Serine-1035":[206,274,318,350,376,428],"site":[210,281,360,391,433],"targeted":[211],"ERK.":[213],"Previous":[214],"studies":[215],"ERK":[218,250,465],"as":[219,229,429],"pivotal":[221],"player":[222,232],"promoting":[224,234,290],"tumorgenesis.":[225],"was":[227,238],"migration,":[236],"shown":[240],"be":[242,436],"required":[243],"efficient":[245],"oncogenic":[246],"tumorigenesis.":[247],"However,":[248,371],"whether":[249],"can":[251,435,446],"regulate":[252],"migration":[257,293,305,399],"not":[259,362],"been":[260],"investigated.":[261],"Based":[262],"on":[263],"published":[264],"data":[265],"our":[267],"preliminary":[268],"results,":[269],"hypothesized":[271],"1)":[273],"critical":[287],"HDAC6-mediated":[291],"affecting":[295],"deacetylation":[296],"substrates;":[299],"2)":[301],"promotes":[303,340,414],"vivo.":[307],"vitro":[310],"vivo":[313,417],"studies,":[314],"confirmed":[316],"phosphorylated":[322,437],"ERK1.":[324],"addition,":[326],"found":[328],"ERK-mitogen":[333],"activated":[334],"protein":[335],"(MAPK)":[337],"signaling":[338,460],"axis":[339],"phosphorylation.":[342],"By":[343],"using":[344,400,418],"unphosphorylation":[345,355,372],"mimicking":[346],"mutants":[347],"site,":[351],"observed":[353],"at":[358,375,389],"this":[359,390,424,441],"does":[361],"enzymatic":[365],"histones":[368],"or":[369],"cortactin.":[370],"hinders":[377],"HDAC6\u2019s":[378],"ability":[379,395],"deacetylate":[381],"\u03b2-catenin.":[384],"Importantly,":[385],"hypo-phosphorylation":[386],"significantly":[392],"attenuates":[393],"lines":[403],"model.":[404,421],"We":[405],"showed":[406],"first":[409],"time":[410],"metastasis":[415],"mouse":[420],"conclusion,":[423],"study":[425],"novel":[431],"ERK1,":[439],"status":[443],"Since":[450],"ERK-MAPK":[452],"pathway":[453],"target":[457],"events,":[461],"inhibitors":[462],"both":[464],"may":[468],"prove":[469],"beneficial":[470],"future":[472],"research":[473],"directions.":[474]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}