{"id":"https://openalex.org/W60539822","doi":"https://doi.org/10.1007/978-3-540-70941-1_11","title":"Engineering Nucleobases and Polymerases for an Expanded Genetic Alphabet","display_name":"Engineering Nucleobases and Polymerases for an Expanded Genetic Alphabet","publication_year":2009,"publication_date":"2009-01-06","ids":{"openalex":"https://openalex.org/W60539822","doi":"https://doi.org/10.1007/978-3-540-70941-1_11","mag":"60539822"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-540-70941-1_11","doi":"https://doi.org/10.1007/978-3-540-70941-1_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-540-70941-1_11","pdf_url":null,"source":{"id":"https://openalex.org/S4210194239","display_name":"Nucleic acids and molecular biology","issn_l":"0933-1891","issn":["0933-1891","1869-2486"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids and Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4205124343","display_name":"Protein Engineering"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047874372","display_name":"Aaron M. Leconte","orcid":"https://orcid.org/0000-0002-5789-9147","observed_orcids":["https://orcid.org/0000-0002-5789-9147"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. M. Leconte","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, La Jolla, USA","THE SCRIPPS RESEARCH INSTITUTE;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"THE SCRIPPS RESEARCH INSTITUTE;","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025948470","display_name":"Floyd E. Romesberg","orcid":"https://orcid.org/0000-0001-6317-1315","observed_orcids":["https://orcid.org/0000-0001-6317-1315"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. E. Romesberg","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, La Jolla, USA","THE SCRIPPS RESEARCH INSTITUTE;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, La Jolla, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"THE SCRIPPS RESEARCH INSTITUTE;","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":1.582,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.81100514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"291","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expanded-genetic-alphabet","display_name":"expanded genetic alphabet","score":0.984000027179718},{"id":"https://openalex.org/keywords/unnatural-nucleobases","display_name":"unnatural nucleobases","score":0.7860000133514404},{"id":"https://openalex.org/keywords/shape-complementarity","display_name":"shape complementarity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.42800000309944153},{"id":"https://openalex.org/keywords/dna-hybridization","display_name":"DNA hybridization","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C202269582","wikidata":"https://www.wikidata.org/wiki/Q2644277","display_name":"Complementarity (molecular biology)","level":2,"score":0.6516506671905518},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.61469966173172},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.6019623875617981},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5635538697242737},{"id":"https://openalex.org/C185581394","wikidata":"https://www.wikidata.org/wiki/Q145911","display_name":"Base pair","level":3,"score":0.5605329275131226},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5385367274284363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5339775085449219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48493364453315735},{"id":"https://openalex.org/C112876837","wikidata":"https://www.wikidata.org/wiki/Q837518","display_name":"Alphabet","level":2,"score":0.4644380211830139},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.41672825813293457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15756991505622864},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0781775712966919},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-540-70941-1_11","doi":"https://doi.org/10.1007/978-3-540-70941-1_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-540-70941-1_11","pdf_url":null,"source":{"id":"https://openalex.org/S4210194239","display_name":"Nucleic acids and molecular biology","issn_l":"0933-1891","issn":["0933-1891","1869-2486"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids and Molecular Biology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W139877098","https://openalex.org/W1566430606","https://openalex.org/W1581466567","https://openalex.org/W1967625585","https://openalex.org/W1967941593","https://openalex.org/W1969847419","https://openalex.org/W1970518586","https://openalex.org/W1973488583","https://openalex.org/W1978649037","https://openalex.org/W1978910509","https://openalex.org/W1985790087","https://openalex.org/W1990734020","https://openalex.org/W1991900407","https://openalex.org/W1996371195","https://openalex.org/W1998588829","https://openalex.org/W2001668844","https://openalex.org/W2004535059","https://openalex.org/W2012797635","https://openalex.org/W2013194374","https://openalex.org/W2013408567","https://openalex.org/W2014926979","https://openalex.org/W2016066488","https://openalex.org/W2022280116","https://openalex.org/W2025962542","https://openalex.org/W2039901169","https://openalex.org/W2044199954","https://openalex.org/W2046294135","https://openalex.org/W2046387060","https://openalex.org/W2052781717","https://openalex.org/W2054436276","https://openalex.org/W2055528600","https://openalex.org/W2058317622","https://openalex.org/W2061465687","https://openalex.org/W2063308005","https://openalex.org/W2063735256","https://openalex.org/W2065164352","https://openalex.org/W2070226713","https://openalex.org/W2073775872","https://openalex.org/W2074588113","https://openalex.org/W2080480370","https://openalex.org/W2081612586","https://openalex.org/W2082807207","https://openalex.org/W2083050412","https://openalex.org/W2086293791","https://openalex.org/W2088880971","https://openalex.org/W2089891949","https://openalex.org/W2089898350","https://openalex.org/W2092836572","https://openalex.org/W2100531374","https://openalex.org/W2101606283","https://openalex.org/W2103311193","https://openalex.org/W2107956226","https://openalex.org/W2108841871","https://openalex.org/W2121907606","https://openalex.org/W2125609304","https://openalex.org/W2126466006","https://openalex.org/W2131286114","https://openalex.org/W2133282256","https://openalex.org/W2134952259","https://openalex.org/W2137713778","https://openalex.org/W2142513910","https://openalex.org/W2143064529","https://openalex.org/W2144107858","https://openalex.org/W2144464722","https://openalex.org/W2152049155","https://openalex.org/W2152304921","https://openalex.org/W2156113162","https://openalex.org/W2157902582","https://openalex.org/W2159943506","https://openalex.org/W2165639777","https://openalex.org/W2168957998","https://openalex.org/W2416194960"],"related_works":["https://openalex.org/W2001319413","https://openalex.org/W2016066488","https://openalex.org/W2050857594","https://openalex.org/W2065164352","https://openalex.org/W2766664307","https://openalex.org/W2621582391","https://openalex.org/W7119490235","https://openalex.org/W4385368835","https://openalex.org/W2727349514","https://openalex.org/W2073880037"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}