{"id":"https://openalex.org/W60533858","doi":null,"title":"Antioxidant protection against hypochlorous acid in human plasma.","display_name":"Antioxidant protection against hypochlorous acid in human plasma.","publication_year":1993,"publication_date":"1993-02-01","ids":{"openalex":"https://openalex.org/W60533858","mag":"60533858","pmid":"https://pubmed.ncbi.nlm.nih.gov/8381845"},"language":"en","primary_location":{"id":"pmid:8381845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8381845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105520177","display_name":"Miao\u2010Lin Hu","orcid":"https://orcid.org/0000-0002-9927-4209","observed_orcids":["https://orcid.org/0000-0002-9927-4209"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M L Hu","raw_affiliation_strings":["Department of Pulmonary-Critical Care Medicine, University of California-Davis Medical Center, Sacramento 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary-Critical Care Medicine, University of California-Davis Medical Center, Sacramento 95817","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091645401","display_name":"Samuel Louie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Louie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110140495","display_name":"CE Cross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C E Cross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061252646","display_name":"Paul A. Motchnik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Motchnik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053726981","display_name":"Barry B. Halliwell","orcid":"https://orcid.org/0000-0002-3560-7123","observed_orcids":["https://orcid.org/0000-0002-3560-7123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Halliwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0567,"has_fulltext":false,"cited_by_count":310,"citation_normalized_percentile":{"value":0.957902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"121","issue":"2","first_page":"257","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.21850000321865082,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypochlorous-acid","display_name":"hypochlorous acid","score":1.0},{"id":"https://openalex.org/keywords/hypochlorite","display_name":"hypochlorite","score":0.7699999809265137},{"id":"https://openalex.org/keywords/human-plasma","display_name":"human plasma","score":0.6240000128746033},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.8159999847412109},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9879999756813049},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.5529999732971191},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ubiquinol-10","display_name":"ubiquinol-10","score":0.9300000071525574},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.828000009059906},{"id":"https://openalex.org/keywords/vitamin-c-supplementation","display_name":"vitamin C supplementation","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.8715722560882568},{"id":"https://openalex.org/C2780908991","wikidata":"https://www.wikidata.org/wiki/Q407318","display_name":"Hypochlorous acid","level":2,"score":0.8170427680015564},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7592060565948486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6910097002983093},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6482837200164795},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5990316867828369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5923686623573303},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5462521910667419},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.5117904543876648},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.5013484954833984},{"id":"https://openalex.org/C2776573510","wikidata":"https://www.wikidata.org/wiki/Q3922210","display_name":"Pro-oxidant","level":3,"score":0.4561946988105774},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.45038795471191406},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4299390912055969},{"id":"https://openalex.org/C56783068","wikidata":"https://www.wikidata.org/wiki/Q172867","display_name":"Scavenger","level":3,"score":0.41405731439590454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17253640294075012},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1227683424949646},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.11961135268211365},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.059102535247802734}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006997","descriptor_name":"Hypochlorous Acid","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006997","descriptor_name":"Hypochlorous Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8381845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8381845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:60533858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8381845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6343528144","display_name":"LUNG SURFACE ANTIOXIDANT DEFENSES AGAINST AIR POLLUTANTS","funder_award_id":"R01HL047628","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005337709","https://openalex.org/W1529656635","https://openalex.org/W1233091568","https://openalex.org/W2279694726","https://openalex.org/W1997731166","https://openalex.org/W2362510050","https://openalex.org/W2012600746","https://openalex.org/W2089772634","https://openalex.org/W2059913529","https://openalex.org/W2534844345"],"abstract_inverted_index":{"Hypochlorous":[0],"acid":[1,38,111,147],"(HOCI)":[2],"is":[3],"a":[4,79,128,151],"powerful":[5],"oxidizing":[6],"and":[7,39,137,179],"chlorinating":[8],"agent":[9],"produced":[10,88],"by":[11,118,133],"the":[12,62,119],"neutrophil":[13],"enzyme":[14],"myeloperoxidase.":[15],"The":[16],"antioxidant":[17],"defenses":[18],"of":[19,29,36,45,66,97,105,131],"freshly":[20],"prepared":[21],"human":[22],"plasma":[23,32,73,94,138],"against":[24,84],"HOCI/OCI-":[25,30,87,134],"were":[26,60],"explored.":[27],"Addition":[28],"to":[31,54,72,77,108],"caused":[33,74],"rapid":[34],"oxidation":[35],"ascorbic":[37],"thiol":[40],"(-SH)":[41],"groups":[42,50,126],"but":[43,68],"not":[44],"uric":[46],"acid.":[47],"Plasma":[48],"-SH":[49,125],"(which":[51],"are":[52,127],"known":[53],"be":[55,141,164],"largely":[56],"located":[57],"on":[58],"albumin)":[59],"quantitatively":[61],"most":[63],"important":[64,81,143,165],"scavenger":[65],"HOCI/OCI-,":[67],"adding":[69],"extra":[70],"ascorbate":[71],"this":[75,159],"molecule":[76],"have":[78],"more":[80],"scavenging":[82],"role":[83],"HOCI/OCI-.":[85],"Added":[86],"no":[89],"detectable":[90],"lipid":[91],"peroxidation":[92],"in":[93,135,155,166],"or":[95,101],"depletion":[96],"lipid-soluble":[98],"antioxidants":[99],"(alpha-tocopherol":[100],"ubiquinol-10).":[102],"No":[103],"evidence":[104],"oxidative":[106],"damage":[107],"protein":[109],"amino":[110],"residues":[112],"(other":[113],"than":[114],"-SH)":[115],"was":[116],"detected":[117],"carbonyl":[120],"assay.":[121],"It":[122],"seems":[123],"that":[124],"major":[129],"target":[130],"attack":[132],"vivo,":[136],"albumin":[139,171],"may":[140],"an":[142],"protective":[144,152],"antioxidant.":[145],"Ascorbic":[146],"might":[148,162],"also":[149,163],"play":[150],"role,":[153],"especially":[154],"individuals":[156],"supplemented":[157],"with":[158,169],"vitamin.":[160],"Ascorbate":[161],"extracellular":[167],"fluids":[168],"low":[170],"concentrations":[172],"such":[173],"as":[174],"synovial,":[175],"respiratory":[176],"tract":[177],"lining,":[178],"cerebrospinal":[180],"fluids.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
