{"id":"https://openalex.org/W60487933","doi":null,"title":"TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes.","display_name":"TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes.","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W60487933","mag":"60487933","pmid":"https://pubmed.ncbi.nlm.nih.gov/11431443"},"language":"en","primary_location":{"id":"pmid:11431443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11431443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023120074","display_name":"G\u00fclg\u00fcn Tezel","orcid":"https://orcid.org/0000-0001-7153-979X","observed_orcids":["https://orcid.org/0000-0001-7153-979X","https://orcid.org/0000-0001-6125-9583"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Tezel","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. tezelg@vision.wustl.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. tezelg@vision.wustl.edu","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070271390","display_name":"Lin Ya Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Y Li","raw_affiliation_strings":["From the Departments of Ophthalmology and Visual Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and Visual Sciences and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"R V Patil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R V Patil","raw_affiliation_strings":["Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033711503","display_name":"Martin B. Wax","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M B Wax","raw_affiliation_strings":["From the Departments of Ophthalmology and Visual Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Ophthalmology and Visual Sciences and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.0444,"has_fulltext":false,"cited_by_count":399,"citation_normalized_percentile":{"value":0.99187906,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"42","issue":"8","first_page":"1787","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tnf-receptor-1","display_name":"TNF receptor 1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.9520000219345093},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8920000195503235},{"id":"https://openalex.org/keywords/inner-retina","display_name":"inner retina","score":0.7170000076293945},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.8022316694259644},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.758903443813324},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6758569478988647},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5650123357772827},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4869721829891205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4623291492462158},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.449042946100235},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.4225567579269409},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.41066765785217285},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3923550248146057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3511252701282501},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3467365503311157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31937259435653687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3008677363395691},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2267933487892151},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.21571078896522522},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09851604700088501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.044873982667922974},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11431443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11431443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:60487933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11431443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3683612259","display_name":"HEAT SHOCK PROTEINS AND THEIR ANTIBODIES IN GLAUCOMA","funder_award_id":"R01EY012314","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W4657569","https://openalex.org/W52361882","https://openalex.org/W98985237","https://openalex.org/W1231432958","https://openalex.org/W1487068141","https://openalex.org/W1509884519","https://openalex.org/W1531683153","https://openalex.org/W1539182279","https://openalex.org/W1601103168","https://openalex.org/W1613790181","https://openalex.org/W1624269173","https://openalex.org/W1683598352","https://openalex.org/W1964830665","https://openalex.org/W1967754061","https://openalex.org/W1971668430","https://openalex.org/W1972254081","https://openalex.org/W1977259886","https://openalex.org/W1978438594","https://openalex.org/W1980655887","https://openalex.org/W1986647322","https://openalex.org/W1989759348","https://openalex.org/W1991763618","https://openalex.org/W1993051562","https://openalex.org/W1996002031","https://openalex.org/W1996846717","https://openalex.org/W2008343355","https://openalex.org/W2010057617","https://openalex.org/W2012049966","https://openalex.org/W2015235156","https://openalex.org/W2016591325","https://openalex.org/W2019132331","https://openalex.org/W2020793434","https://openalex.org/W2021426605","https://openalex.org/W2023249515","https://openalex.org/W2028340150","https://openalex.org/W2034882426","https://openalex.org/W2036528355","https://openalex.org/W2037254721","https://openalex.org/W2039768122","https://openalex.org/W2040070598","https://openalex.org/W2040957577","https://openalex.org/W2044569533","https://openalex.org/W2047173690","https://openalex.org/W2052615942","https://openalex.org/W2054555689","https://openalex.org/W2059450704","https://openalex.org/W2068089215","https://openalex.org/W2069132198","https://openalex.org/W2070360570","https://openalex.org/W2074783627","https://openalex.org/W2076339827","https://openalex.org/W2076369272","https://openalex.org/W2077900427","https://openalex.org/W2082409249","https://openalex.org/W2083401716","https://openalex.org/W2084352924","https://openalex.org/W2087850181","https://openalex.org/W2122175586","https://openalex.org/W2122477596","https://openalex.org/W2123446167","https://openalex.org/W2124964170","https://openalex.org/W2125506149","https://openalex.org/W2126998721","https://openalex.org/W2127338217","https://openalex.org/W2129229503","https://openalex.org/W2129575632","https://openalex.org/W2129801260","https://openalex.org/W2134769368","https://openalex.org/W2135388629","https://openalex.org/W2147122201","https://openalex.org/W2153126147","https://openalex.org/W2163455134","https://openalex.org/W2163828800","https://openalex.org/W2170147408","https://openalex.org/W2199768547","https://openalex.org/W2319735638","https://openalex.org/W2415499460","https://openalex.org/W2417691476","https://openalex.org/W2582398023","https://openalex.org/W2883780929"],"related_works":["https://openalex.org/W7100619960","https://openalex.org/W2019132331","https://openalex.org/W2081703291","https://openalex.org/W4250002568","https://openalex.org/W1563498244","https://openalex.org/W2134769368","https://openalex.org/W2369926565","https://openalex.org/W1170725541","https://openalex.org/W2041241532","https://openalex.org/W2035619140"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"the":[3,16,62,65,68,131,147,159,181],"expression":[4,31],"and":[5,12,20,26,32,36,51,67,120,167],"localization":[6,33],"of":[7,18,34,47,54,64,70,83,90,122,165,184],"tumor":[8],"necrosis":[9],"factor":[10],"(TNF)-alpha":[11],"TNF-alpha":[13,35,37,74,102,104,123,125,142,153,166],"receptor-1":[14,38,105,126,154,169],"in":[15,27,41,80,87,110,114,146,158,170,180],"retina":[17,42,81,172],"normal":[19,56,92],"glaucomatous":[21,84,111,171],"eyes.":[22,117],"METHODS:":[23],"Using":[24],"immunohistochemistry":[25],"situ":[28,95],"hybridization,":[29],"retinal":[30,133,139,160],"were":[39,78,106,127],"studied":[40],"sections":[43,82],"from":[44],"20":[45,52],"eyes":[46,53,85,89,112],"donors":[48],"with":[49],"glaucoma,":[50],"age-matched":[55,91,115],"donors.":[57,93],"RESULTS:":[58],"According":[59],"to":[60,130],"immunohistochemistry,":[61],"intensity":[63],"immunostaining":[66,140,151],"number":[69],"labeled":[71],"cells":[72],"for":[73,101,141,152],"or":[75,103,124],"its":[76,168],"receptor":[77],"greater":[79],"than":[86,113],"control":[88,116],"In":[94],"hybridization":[96],"showed":[97],"that":[98,138,174],"mRNA":[99,121],"signals":[100],"similarly":[107],"more":[108],"intense":[109],"Both":[118],"protein":[119],"predominantly":[128,144],"localized":[129],"inner":[132],"layers.":[134],"Double-immunofluorescence":[135],"labeling":[136],"demonstrated":[137],"was":[143,155],"positive":[145,157],"glial":[148],"cells,":[149],"whereas":[150],"mainly":[156],"ganglion":[161],"cells.":[162],"CONCLUSIONS:":[163],"Upregulation":[164],"suggest":[173],"TNF-alpha-mediated":[175],"cell":[176],"death":[177],"is":[178],"involved":[179],"neurodegeneration":[182],"process":[183],"glaucoma.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":24}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
