{"id":"https://openalex.org/W603215748","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9618","title":"Feasibility of breast conserving treatment for breast cancer in women with germline BRCA mutations: A clinic-based series","display_name":"Feasibility of breast conserving treatment for breast cancer in women with germline BRCA mutations: A clinic-based series","publication_year":2004,"publication_date":"2004-07-15","ids":{"openalex":"https://openalex.org/W603215748","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9618","mag":"603215748"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2004.22.14_suppl.9618","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9618","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.9618","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045514288","display_name":"Mark E. Robson","orcid":"https://orcid.org/0000-0002-3109-1692","observed_orcids":["https://orcid.org/0000-0002-3109-1692"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Robson","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053789741","display_name":"T. Holcombe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Holcombe","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032257865","display_name":"Beryl L. McCormick","orcid":"https://orcid.org/0000-0002-4550-0565","observed_orcids":["https://orcid.org/0000-0002-4550-0565"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. McCormick","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038968411","display_name":"Patrick Ivan Borgen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Borgen","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109515631","display_name":"T. Gulati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Gulati","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112814076","display_name":"S.C. Jhanwar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Jhanwar","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000753119","display_name":"Noah D. Kauff","orcid":"https://orcid.org/0000-0001-7242-6156","observed_orcids":["https://orcid.org/0000-0001-7242-6156"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Kauff","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001275266","display_name":"C. Hudis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Hudis","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039225060","display_name":"Larry Norton","orcid":"https://orcid.org/0000-0003-3701-9250","observed_orcids":["https://orcid.org/0000-0003-3701-9250"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Norton","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001757617","display_name":"Kenneth Offit","orcid":"https://orcid.org/0000-0002-2180-2032","observed_orcids":["https://orcid.org/0000-0002-2180-2032"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Offit","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"14_suppl","first_page":"9618","last_page":"9618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-conserving-therapy","display_name":"breast-conserving therapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.8820000290870667},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.6320000290870667},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/germline-brca-mutation","display_name":"germline BRCA mutation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/wide-local-excision","display_name":"wide local excision","score":0.9860000014305115},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/contralateral-breast-cancer","display_name":"contralateral breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bilateral-prophylactic-mastectomy","display_name":"bilateral prophylactic mastectomy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.8240000009536743},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.5609999895095825},{"id":"https://openalex.org/keywords/young-women","display_name":"young women","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9423079490661621},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7729939222335815},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.615247905254364},{"id":"https://openalex.org/C2910039337","wikidata":"https://www.wikidata.org/wiki/Q16394661","display_name":"Prophylactic Mastectomy","level":5,"score":0.5889154672622681},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5647615194320679},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.5439978837966919},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5343377590179443},{"id":"https://openalex.org/C2780194787","wikidata":"https://www.wikidata.org/wiki/Q4836333","display_name":"BRCA mutation","level":4,"score":0.5045899152755737},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4829844534397125},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.44830620288848877},{"id":"https://openalex.org/C80227256","wikidata":"https://www.wikidata.org/wiki/Q1124169","display_name":"Genetic counseling","level":2,"score":0.41873684525489807},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2004.22.14_suppl.9618","doi":"https://doi.org/10.1200/jco.2004.22.14_suppl.9618","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.14_suppl.9618","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.1200/jco.2004.22.90140.9618","doi":"https://doi.org/10.1200/jco.2004.22.90140.9618","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2004.22.90140.9618","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1995498471","https://openalex.org/W3010340199","https://openalex.org/W7099602408","https://openalex.org/W2032628103","https://openalex.org/W2077378963","https://openalex.org/W1969778448","https://openalex.org/W2081943419","https://openalex.org/W2073129224","https://openalex.org/W2108979944","https://openalex.org/W3037426265"],"abstract_inverted_index":{"9618":[0],"Background:":[1],"The":[2,71,147,192],"management":[3],"of":[4,19,106,141,149,164,178,218,244,254],"women":[5,25,73,169,206,236],"with":[6,26,44,114,170,207,211,237],"BRCA-associated":[7],"hereditary":[8],"breast":[9,20,56,144,180],"cancer":[10,57,145,181],"(BAHBC)":[11],"remains":[12],"incompletely":[13],"defined.":[14],"We":[15],"evaluated":[16],"the":[17,176,226,232,241],"appropriateness":[18],"conserving":[21],"therapy":[22],"(BCT)":[23],"in":[24,38,205,235],"BAHBC.":[27,171],"Methods:":[28],"Between":[29],"May":[30],"1992":[31],"and":[32,67,117,126,156,187,225,246],"December":[33],"2003,":[34],"103":[35,72,174],"female":[36],"participants":[37],"genetic":[39,200],"testing":[40,201],"protocols":[41],"were":[42,65,103,134,166],"identified":[43,167],"deleterious":[45],"BRCA":[46],"mutations":[47],"(72":[48],"BRCA1,":[49,110],"31":[50],"BRCA2),":[51],"whose":[52],"initial":[53],"treatment":[54],"for":[55,76,228],"was":[58,87,123,129,151,182,202],"wide":[59],"local":[60],"excision":[61],"(WLE).":[62],"Clinical":[63],"records":[64],"reviewed":[66],"follow-up":[68,128],"updated.":[69],"Results:":[70],"underwent":[74],"WLE":[75,94,116],"115":[77],"BAHBC":[78,108,212],"(108":[79],"invasive,":[80],"7":[81],"DCIS).":[82],"In":[83,172],"17":[84],"cases,":[85],"RT":[86],"not":[88],"delivered":[89],"(16":[90],"prophylactic":[91],"mastectomy":[92,230,256],"after":[93],"but":[95],"before":[96],"RT,":[97],"1":[98],"active":[99],"ovarian":[100],"cancer).":[101],"There":[102,133],"91":[104],"cases":[105,136],"invasive":[107],"(65":[109],"26":[111],"BRCA2)":[112],"treated":[113],"both":[115],"RT.":[118],"Median":[119],"age":[120],"at":[121,153,158,184,189],"diagnosis":[122,198],"43":[124],"years,":[125],"median":[127],"65.7":[130],"months":[131,155,186],"(12.8\u2013234.6).":[132],"11":[135],"(9":[137],"DCIS,":[138],"2":[139],"invasive)":[140],"metachronous":[142],"ipsilateral":[143],"(MIBC).":[146],"risk":[148,177,217],"MIBC":[150,165,220,249],"11.5%":[152],"60":[154,185],"14.0%":[157],"120":[159,190],"months.":[160,191],"No":[161],"factors":[162],"predictive":[163],"among":[168],"all":[173],"women,":[175,224],"contralateral":[179],"13.7%":[183],"39.1%":[188],"mean":[193],"interval":[194],"from":[195],"first":[196],"BC":[197],"to":[199],"significantly":[203],"longer":[204],"CBC.":[208],"Conclusions:":[209],"Women":[210],"undergoing":[213],"BCT":[214],"have":[215],"similar":[216],"early":[219],"as":[221,234,257],"unselected":[222],"young":[223],"indications":[227],"therapeutic":[229],"are":[231],"same":[233],"non-hereditary":[238],"cancer.":[239],"However,":[240],"significant":[242],"risks":[243],"CBC":[245],"possibly":[247],"late":[248],"may":[250],"prompt":[251],"serious":[252],"consideration":[253],"bilateral":[255],"a":[258],"preventive":[259],"measure.":[260],"Author":[261],"Disclosure":[262],"Employment":[263],"or":[264,267],"Leadership":[265],"Consultant":[266],"Advisory":[268],"Stock":[269],"Ownership":[270],"Honoraria":[271],"Research":[272],"Funding":[273],"Expert":[274],"Testimony":[275],"Other":[276],"Remuneration":[277],"Myriad":[278],"Genetics":[279]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
