{"id":"https://openalex.org/W600765365","doi":null,"title":"Biological Insights from Single-Particle Tracking in Living Cells","display_name":"Biological Insights from Single-Particle Tracking in Living Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W600765365","mag":"600765365"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-229342","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229342","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229342","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035533045","display_name":"Arash Sanamrad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Arash Sanamrad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035533045"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10288","display_name":"Fractional Differential Equations Solutions","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-particle-tracking","display_name":"single-particle tracking","score":0.9929999709129333},{"id":"https://openalex.org/keywords/intracellular-diffusion","display_name":"intracellular diffusion","score":0.8550000190734863},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cytoplasmic-diffusion","display_name":"cytoplasmic diffusion","score":0.7129999995231628},{"id":"https://openalex.org/keywords/trajectory-simulation","display_name":"trajectory simulation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ribosomal-subunits","display_name":"ribosomal subunits","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nucleoid","display_name":"nucleoid","score":0.6230000257492065},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.4749999940395355},{"id":"https://openalex.org/keywords/nucleoid-compaction","display_name":"nucleoid compaction","score":0.7009999752044678},{"id":"https://openalex.org/keywords/photoconvertible-fluorescent-proteins","display_name":"photoconvertible fluorescent proteins","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C53642103","wikidata":"https://www.wikidata.org/wiki/Q459485","display_name":"Nucleoid","level":4,"score":0.9756715297698975},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.8027129769325256},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.614854097366333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6049143671989441},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.5747132301330566},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5084313750267029},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42476382851600647},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.42024195194244385},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.41464605927467346},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3981623649597168},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3570701777935028},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.3558337092399597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2802359461784363}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-229342","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229342","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:600765365","doi":null,"is_oa":false,"landing_page_url":"https://uu.diva-portal.org/smash/get/diva2:736592/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-229342","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229342","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W64946708","https://openalex.org/W88241651","https://openalex.org/W1515304043","https://openalex.org/W1568597106","https://openalex.org/W1585402634","https://openalex.org/W1586165461","https://openalex.org/W1695535299","https://openalex.org/W1883779479","https://openalex.org/W1967407306","https://openalex.org/W1969302126","https://openalex.org/W1971144253","https://openalex.org/W1974251842","https://openalex.org/W1975497257","https://openalex.org/W1978249718","https://openalex.org/W1978270801","https://openalex.org/W1980695770","https://openalex.org/W1981765336","https://openalex.org/W1982070906","https://openalex.org/W1988278060","https://openalex.org/W1990867102","https://openalex.org/W1992858116","https://openalex.org/W1993645665","https://openalex.org/W1997377016","https://openalex.org/W1999187172","https://openalex.org/W2003409413","https://openalex.org/W2003453431","https://openalex.org/W2004225393","https://openalex.org/W2007971802","https://openalex.org/W2008490130","https://openalex.org/W2008507782","https://openalex.org/W2009448652","https://openalex.org/W2012350022","https://openalex.org/W2012732176","https://openalex.org/W2014293907","https://openalex.org/W2014361215","https://openalex.org/W2017934591","https://openalex.org/W2018639243","https://openalex.org/W2020431548","https://openalex.org/W2032579724","https://openalex.org/W2034876354","https://openalex.org/W2035578856","https://openalex.org/W2039062180","https://openalex.org/W2040204840","https://openalex.org/W2040714740","https://openalex.org/W2053101927","https://openalex.org/W2054241952","https://openalex.org/W2054455698","https://openalex.org/W2055214702","https://openalex.org/W2058946062","https://openalex.org/W2060177007","https://openalex.org/W2062651595","https://openalex.org/W2066383202","https://openalex.org/W2068372433","https://openalex.org/W2069813642","https://openalex.org/W2070353646","https://openalex.org/W2071051512","https://openalex.org/W2071647127","https://openalex.org/W2073805463","https://openalex.org/W2074759798","https://openalex.org/W2075234068","https://openalex.org/W2076353383","https://openalex.org/W2076452367","https://openalex.org/W2077835601","https://openalex.org/W2084312697","https://openalex.org/W2084456919","https://openalex.org/W2085620516","https://openalex.org/W2086128646","https://openalex.org/W2087346416","https://openalex.org/W2091634027","https://openalex.org/W2092591295","https://openalex.org/W2095442369","https://openalex.org/W2095658523","https://openalex.org/W2099051954","https://openalex.org/W2101336703","https://openalex.org/W2101703936","https://openalex.org/W2105110539","https://openalex.org/W2108330014","https://openalex.org/W2109168096","https://openalex.org/W2110648715","https://openalex.org/W2111745935","https://openalex.org/W2115737236","https://openalex.org/W2116137883","https://openalex.org/W2123589399","https://openalex.org/W2125577771","https://openalex.org/W2132328962","https://openalex.org/W2134153749","https://openalex.org/W2139004845","https://openalex.org/W2143539785","https://openalex.org/W2148051631","https://openalex.org/W2148192047","https://openalex.org/W2150381125","https://openalex.org/W2152763121","https://openalex.org/W2157189708","https://openalex.org/W2161435888","https://openalex.org/W2165149777","https://openalex.org/W2171539493","https://openalex.org/W2339523664"],"related_works":["https://openalex.org/W2022437289","https://openalex.org/W1873473567","https://openalex.org/W2149481268","https://openalex.org/W2810456980","https://openalex.org/W7043297636","https://openalex.org/W2913128502","https://openalex.org/W2346313207","https://openalex.org/W3004763904","https://openalex.org/W3217100096","https://openalex.org/W2886851586"],"abstract_inverted_index":{"Single-particle":[0,71,152],"tracking":[1,63,72,87,153,192],"is":[2,164,287],"a":[3,66,69,110,185],"technique":[4],"that":[5,139,243,285,290,304],"allows":[6,292],"for":[7,184],"quantitative":[8],"analysis":[9],"of":[10,15,29,44,54,80,95,136,202,217,219,245,258,307,316],"the":[11,27,52,78,93,96,123,134,169,200,215,237,251,255,279,301,305,313,323],"localization":[12],"and":[13,25,62,88,145,179,213,221,260,303],"movement":[14],"particles.":[16,81],"In":[17],"this":[18],"technique,":[19],"trajectories":[20],"are":[21,107,146,233,275,310],"constructed":[22],"by":[23,50,312],"determining":[24],"connecting":[26],"positions":[28],"individual":[30,48,162,207],"particles":[31,45,53,138],"from":[32,236,278],"consecutive":[33],"images.":[34],"Recent":[35],"advances":[36],"have":[37],"made":[38],"it":[39,286],"possible":[40],"to":[41,76,91,132,158,198,295,319],"track":[42],"hundreds":[43],"in":[46,100,113,122,193,322],"an":[47,161],"cell":[49],"labeling":[51],"interest":[55],"with":[56,109,143,262],"photoactivatable":[57],"or":[58,65,166,182,211],"photoconvertible":[59],"fluorescent":[60,97],"proteins":[61],"one":[64],"few":[67],"at":[68,118,148],"time.":[70,187],"can":[73,129,140,154,248],"be":[74,130,141,156],"used":[75,131,157],"study":[77,92,133],"diffusion":[79,94,135],"Here,":[82,188],"we":[83,189],"use":[84,190],"intracellular":[85,137],"single-particle":[86,191],"trajectory":[89],"simulations":[90],"protein":[98],"mEos2":[99,115,144],"living":[101,194],"Escherichia":[102],"coli":[103,125,196],"cells.":[104],"Our":[105,127],"data":[106],"consistent":[108],"simple":[111],"model":[112],"which":[114,253],"diffuses":[116,172],"normally":[117,291],"13":[119],"\u00b5m2":[120],"s\u22121":[121],"E.":[124,195],"cytoplasm.":[126],"approach":[128],"labeled":[142],"present":[147],"high":[149],"copy":[150],"numbers.":[151],"also":[155,266],"determine":[159,199],"whether":[160],"particle":[163,171],"bound":[165,181,220,229],"free":[167,170,183,203,210,222,231,272],"if":[168],"significantly":[173],"faster":[174],"than":[175],"its":[176],"binding":[177],"targets":[178],"remains":[180],"long":[186],"cells":[197],"fractions":[201],"ribosomal":[204,293,317],"subunits,":[205,230],"classify":[206],"subunits":[208,223,232,294,318],"as":[209],"mRNA-bound,":[212],"quantify":[214],"degree":[216],"exclusion":[218],"separately.":[224],"We":[225,265],"show":[226,267],"that,":[227,268],"unlike":[228],"not":[234],"excluded":[235,277],"nucleoid.":[238,281,325],"This":[239,282],"finding":[240,283],"strongly":[241],"suggests":[242],"translation":[244,270,289,308],"nascent":[246,298,320],"mRNAs":[247,299,321],"start":[249],"throughout":[250,300],"nucleoid,":[252],"reconciles":[254],"spatial":[256],"separation":[257],"DNA":[259],"ribosomes":[261],"co-transcriptional":[263],"translation.":[264],"after":[269],"inhibition,":[271],"subunit":[273],"precursors":[274],"partially":[276],"compacted":[280,324],"indicates":[284],"active":[288],"assemble":[296],"on":[297],"nucleoid":[302],"effects":[306],"inhibitors":[309],"enhanced":[311],"limited":[314],"access":[315]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}