{"id":"https://openalex.org/W60068208","doi":null,"title":"Diet and sudden cardiac death.","display_name":"Diet and sudden cardiac death.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W60068208","mag":"60068208","pmid":"https://pubmed.ncbi.nlm.nih.gov/11458288"},"language":"en","primary_location":{"id":"pmid:11458288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11458288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079152086","display_name":"Alexander Leaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A Leaf","raw_affiliation_strings":["Department of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, USA. Aleaf@partners.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, USA. Aleaf@partners.org","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079152086"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":1.3047,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.7868461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"3","first_page":"173","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11083","display_name":"Cardiac Health and Mental Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.9179999828338623},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8640000224113464},{"id":"https://openalex.org/keywords/fish-oil","display_name":"fish oil","score":0.6449999809265137},{"id":"https://openalex.org/keywords/dietary-factors","display_name":"dietary factors","score":0.5490000247955322},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.8809999823570251},{"id":"https://openalex.org/keywords/voltage-dependent-sodium-current","display_name":"voltage-dependent sodium current","score":0.8560000061988831},{"id":"https://openalex.org/keywords/l-type-calcium-current","display_name":"L-type calcium current","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-release","display_name":"sarcoplasmic reticulum calcium release","score":0.8880000114440918},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7220091819763184},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.6475925445556641},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6374576091766357},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.558514416217804},{"id":"https://openalex.org/C2993353509","wikidata":"https://www.wikidata.org/wiki/Q411867","display_name":"Sudden death","level":2,"score":0.5208940505981445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5072965025901794},{"id":"https://openalex.org/C2779946292","wikidata":"https://www.wikidata.org/wiki/Q1786125","display_name":"Fish oil","level":3,"score":0.47342851758003235},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.460244357585907},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4246987998485565},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.41123348474502563},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38510340452194214},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.21836891770362854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20030945539474487},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.17010575532913208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1655469834804535},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005395","descriptor_name":"Fish Oils","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005395","descriptor_name":"Fish Oils","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013610","descriptor_name":"Tachycardia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11458288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11458288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Journal Article"},{"id":"mag:60068208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11458288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6122596465","display_name":"HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS","funder_award_id":"R01HL062284","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G755109007","display_name":"MECHANISM OF DISEASE PREVENTION BY N 3 FATTY ACIDS","funder_award_id":"R01DK038165","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007474904","https://openalex.org/W2081951837","https://openalex.org/W2080689827","https://openalex.org/W2105104503","https://openalex.org/W1968248871","https://openalex.org/W2128470619","https://openalex.org/W2150541210","https://openalex.org/W1985660454","https://openalex.org/W2159709433","https://openalex.org/W2114734166"],"abstract_inverted_index":{"The":[0,45,116,136],"purpose":[1],"of":[2,16,24,55,80,104,108,113,125,133,150,167,170],"this":[3,48,193],"paper":[4],"is":[5,70,195],"to":[6,59],"review":[7],"the":[8,14,17,53,67,75,81,88,97,111,126,130,134,168,176,183,186],"evidence":[9,140],"that":[10,141],"dietary":[11],"factors,":[12],"namely":[13],"ingestion":[15],"n-3":[18,77],"(or":[19],"w-3)":[20],"polyunsaturated":[21],"fatty":[22,57,78,145],"acids":[23,58,79,146],"fish":[25,143],"oils":[26],"can":[27],"prevent":[28],"fatal":[29],"cardiac":[30,34,151],"arrhythmias":[31],"(so-called":[32],"sudden":[33,152],"death)":[35],"in":[36,41,66,84,119,154,175,182],"experimental":[37],"animals,":[38],"and":[39,96,129,179],"probably":[40],"humans":[42,155],"as":[43],"well.":[44],"mechanism":[46],"for":[47],"striking":[49],"effect":[50],"results":[51],"from":[52,192],"ability":[54],"these":[56,142],"directly":[60],"stabilize":[61],"electrically":[62],"every":[63],"contractile":[64],"myocyte":[65],"heart.":[68,135],"This":[69],"accomplished":[71],"by":[72,74],"modulation":[73],"free":[76],"ionic":[82],"currents":[83,91],"heart":[85,114,127],"cells;":[86],"particularly":[87],"voltage-dependent":[89],"sodium":[90],"which":[92,101],"initiate":[93,102],"action":[94],"potentials":[95],"L-type":[98],"calcium":[99,109,121],"currents,":[100],"release":[103],"sarcoplasmic":[105],"reticulum":[106],"stores":[107],"into":[110],"cytosol":[112],"cells.":[115],"resultant":[117],"rise":[118],"cytosolic":[120],"concentration":[122],"initiates":[123],"contraction":[124],"cells":[128],"beating":[131],"rate":[132],"gradually":[137],"accumulating":[138],"clinical":[139],"oil":[144],"are":[147],"potent":[148],"preventors":[149],"death":[153],"will":[156],"be":[157],"reviewed.":[158],"With":[159],"some":[160],"250,000":[161],"deaths":[162],"occurring":[163],"within":[164],"one":[165],"hour":[166],"onset":[169],"acute":[171],"myocardial":[172],"infarctions":[173],"annually":[174],"USA":[177],"alone":[178],"millions":[180],"more":[181],"whole":[184],"world,":[185],"potential":[187],"large":[188],"public":[189],"health":[190],"benefit":[191],"understanding":[194],"evident.":[196]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}