{"id":"https://openalex.org/W600340376","doi":null,"title":"[Mannosylation of ligand binding domain 2 of HER-2/neu].","display_name":"[Mannosylation of ligand binding domain 2 of HER-2/neu].","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W600340376","mag":"600340376","pmid":"https://pubmed.ncbi.nlm.nih.gov/15182632"},"language":"zh","primary_location":{"id":"pmid:15182632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15182632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043881496","display_name":"Xu Ming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Xu","raw_affiliation_strings":["Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060143558","display_name":"Ning Guo","orcid":"https://orcid.org/0009-0005-5706-6400","observed_orcids":["https://orcid.org/0009-0005-5706-6400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017031282","display_name":"\u738b\u7ea2\u971e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-xia Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050530173","display_name":"\u674e\u7231\u73b2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ai-ling Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035795618","display_name":"\u80e1\u7f8e\u8339","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei-ruo Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084063243","display_name":"\u6c88\u500d\u594b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bei-fen Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04135113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"1","first_page":"95","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.9700000286102295},{"id":"https://openalex.org/keywords/protein-glycosylation","display_name":"protein glycosylation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.7549999952316284},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30905652046203613}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15182632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15182632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology","raw_type":"English Abstract"},{"id":"mag:600340376","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/94263A/200401/9422451.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306556889","display_name":"\u7ec6\u80de\u4e0e\u5206\u5b50\u514d\u75ab\u5b66\u6742\u5fd7","issn_l":"1007-8738","issn":["1007-8738"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u7ec6\u80de\u4e0e\u5206\u5b50\u514d\u75ab\u5b66\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2268775256","https://openalex.org/W144078482","https://openalex.org/W2915006747","https://openalex.org/W2340726991","https://openalex.org/W7050062896","https://openalex.org/W2380330168","https://openalex.org/W1585245815","https://openalex.org/W3046423947","https://openalex.org/W7026090244","https://openalex.org/W2008857070"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"establish":[2],"a":[3],"new":[4],"method":[5,67],"for":[6,82],"protein":[7,41],"mannosylation,":[8],"which":[9,78],"will":[10],"facilitate":[11],"the":[12,80,83,95],"study":[13,84],"of":[14,56,62,85,97],"antigen":[15,86],"presentation":[16,89],"mediated":[17,90],"by":[18,47,91],"mannose":[19,92],"receptor.":[20],"METHODS:":[21],"Recombinant":[22],"HER-2/neu":[23],"ligand":[24],"binding":[25],"domain":[26],"2":[27],"(LBD2)":[28],"was":[29,42,59,70],"purified":[30],"through":[31],"DEAE":[32],"sepharose":[33],"FF":[34],"column":[35],"and":[36,49,64,88,94],"cobalt-based":[37],"affinity":[38],"resins.":[39],"LBD2":[40,57,69,73],"mannosylated":[43],"in-vitro,and":[44],"then":[45],"analyzed":[46],"MALDI-TOF-MS":[48,63],"resorcinol-sulfuric":[50,65],"acid":[51,66],"method.":[52],"RESULTS:":[53],"The":[54],"purity":[55],"obtained":[58],"90%.":[60],"Analysis":[61],"suggested":[68],"mannosylated.":[71],"CONCLUSION:":[72],"neoglycoprotein":[74],"has":[75],"been":[76],"obtained,":[77],"lays":[79],"foundation":[81],"uptake":[87],"receptor":[93],"development":[96],"tumor":[98],"vaccine.":[99]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
