{"id":"https://openalex.org/W600211004","doi":"https://doi.org/10.1096/fasebj.20.5.a837-a","title":"Role of Neuropathy Target Esterase (NTE) in high NaCl\u2010induced accumulation of glycerophosphocholine (GPC) by mouse Inner Medullary Collecting Duct 3 (mIMCD3) cells","display_name":"Role of Neuropathy Target Esterase (NTE) in high NaCl\u2010induced accumulation of glycerophosphocholine (GPC) by mouse Inner Medullary Collecting Duct 3 (mIMCD3) cells","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W600211004","doi":"https://doi.org/10.1096/fasebj.20.5.a837-a","mag":"600211004"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.20.5.a837-a","doi":"https://doi.org/10.1096/fasebj.20.5.a837-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.5.a837-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005054637","display_name":"Morgan Gallazzini","orcid":"https://orcid.org/0000-0002-7185-7162","observed_orcids":["https://orcid.org/0000-0002-7185-7162"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Gallazzini","raw_affiliation_strings":["LKEM, NHLBI, NIH, Building 10, Room 6N260, 10 center DR MSC 1603, Bethesda, MD, 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LKEM, NHLBI, NIH, Building 10, Room 6N260, 10 center DR MSC 1603, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051074151","display_name":"Joan D. Ferraris","orcid":"https://orcid.org/0000-0003-4696-2347","observed_orcids":["https://orcid.org/0000-0003-4696-2347"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan D Ferraris","raw_affiliation_strings":["LKEM, NHLBI, NIH, Building 10, Room 6N260, 10 center DR MSC 1603, Bethesda, MD, 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LKEM, NHLBI, NIH, Building 10, Room 6N260, 10 center DR MSC 1603, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025916093","display_name":"Maurice B. Burg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurice B Burg","raw_affiliation_strings":["LKEM, NHLBI, NIH, Building 10, Room 6N260, 10 center DR MSC 1603, Bethesda, MD, 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LKEM, NHLBI, NIH, Building 10, Room 6N260, 10 center DR MSC 1603, Bethesda, MD, 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1359,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46375492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropathy-target-esterase","display_name":"neuropathy target esterase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/glycerophosphocholine","display_name":"glycerophosphocholine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/inner-medullary-collecting-duct","display_name":"inner medullary collecting duct","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mimcd3-cells","display_name":"mIMCD3 cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/phospholipase-b","display_name":"phospholipase B","score":0.9419999718666077},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.8029999732971191},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.843999981880188},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7688474059104919},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.5734577178955078},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.4661995470523834},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44103461503982544},{"id":"https://openalex.org/C2777261171","wikidata":"https://www.wikidata.org/wiki/Q418750","display_name":"Esterase","level":3,"score":0.42584165930747986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3728525936603546},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3487657904624939},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.2197687327861786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11922034621238708},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.20.5.a837-a","doi":"https://doi.org/10.1096/fasebj.20.5.a837-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.5.a837-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2064293313","https://openalex.org/W166402091","https://openalex.org/W2180007197","https://openalex.org/W2404266032","https://openalex.org/W2084976551","https://openalex.org/W34635389","https://openalex.org/W2401621255","https://openalex.org/W2130843143","https://openalex.org/W2091494318","https://openalex.org/W2290288272"],"abstract_inverted_index":{"GPC":[0,30,35,67,125,143,176,205],"is":[1,36,88],"an":[2],"osmoprotective":[3],"compatible":[4],"and":[5,21,112,120,150,172,194,202],"counteracting":[6],"organic":[7],"osmolyte":[8],"that":[9,26,48,53,63,102,188],"accumulates":[10],"in":[11,16,31,93,97,206],"renal":[12],"inner":[13],"medullary":[14],"cells":[15],"response":[17],"to":[18,59,84,177,199],"high":[19,27,91,103,189],"NaCl":[20,28,92,104,190],"urea.":[22],"We":[23,100,186],"previously":[24],"found":[25],"increases":[29,105,132,191],"MDCK":[32],"cells.":[33,208],"The":[34,77],"derived":[37],"from":[38,68],"phosphatidylcholine":[39],"(PC),":[40],"catalyzed":[41],"by":[42,90,115,145,151,167],"increased":[43,98,200],"activity":[44],"of":[45,66,79,204],"a":[46,61,128,159],"phospholipase":[47,62,195],"was":[49,56,83],"not":[50],"identified":[51],"at":[52,117,122,147,153,169,183],"time.":[54],"NTE":[55,87,106,113,138,164,192],"recently":[57],"shown":[58],"be":[60],"catalyzes":[64],"production":[65,201],"PC":[69],"(Zaccheo":[70],"et":[71],"al,":[72],"JBC":[73],"279:":[74],"24024,":[75],"2004).":[76],"purpose":[78],"the":[80,178],"present":[81],"studies":[82],"test":[85],"whether":[86],"activated":[89],"mIMCD3":[94,207],"cells,":[95],"resulting":[96],"GPC.":[99],"find":[101],"mRNA":[107],"3\u2010fold":[108],"within":[109],"8":[110],"hours,":[111],"protein":[114,165],"4\u2010fold":[116],"16":[118],"hours":[119],"8\u2010fold":[121],"48":[123],"hours.":[124],"(measured":[126],"with":[127],"sensitive":[129],"chemiluminescent":[130],"assay)":[131],"2.5\u2010fold.":[133],"Di\u2010isopropyl":[134],"FluoroPhosphate":[135],"(DFP)":[136],"inhibits":[137],"esterase":[139],"activity.":[140],"It":[141],"reduces":[142,163,175],"accumulation":[144,203],"30%":[146],"300":[148,171],"mosmol/kg":[149,155],"40%":[152],"500":[154,173],"(NaCl":[156],"added).":[157],"Further,":[158],"specific":[160],"siRNA,":[161],"which":[162],"abundance":[166],"50%":[168],"both":[170,184],"mosmol/kg,":[174],"same":[179],"extent":[180],"as":[181],"DFP":[182],"osmolalities.":[185],"conclude":[187],"expression":[193],"B":[196],"activity,":[197],"contributing":[198]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}