{"id":"https://openalex.org/W59880676","doi":null,"title":"Corticosteroids for the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP): what evidence?","display_name":"Corticosteroids for the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP): what evidence?","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W59880676","mag":"59880676","pmid":"https://pubmed.ncbi.nlm.nih.gov/17505460"},"language":"en","primary_location":{"id":"pmid:17505460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17505460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva ginecologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050873707","display_name":"Alex C. Vidaeff","orcid":"https://orcid.org/0000-0002-5066-5663","observed_orcids":["https://orcid.org/0000-0002-5066-5663"]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A C Vidaeff","raw_affiliation_strings":["Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77030, USA. alex.c.vidaeff@uth.tmc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77030, USA. alex.c.vidaeff@uth.tmc.edu","institution_ids":["https://openalex.org/I1337852284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048662041","display_name":"Edward R. Yeomans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E R Yeomans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7476,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.91662003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"59","issue":"2","first_page":"183","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hellp-syndrome","display_name":"HELLP syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/disease-modification","display_name":"disease modification","score":0.7870000004768372},{"id":"https://openalex.org/keywords/systemic-inflammatory-response","display_name":"systemic inflammatory response","score":0.734000027179718},{"id":"https://openalex.org/keywords/maternal-fetal-communication","display_name":"maternal-fetal communication","score":0.8180000185966492},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.8619999885559082},{"id":"https://openalex.org/keywords/absent-end-diastolic-flow","display_name":"absent end-diastolic flow","score":0.9210000038146973},{"id":"https://openalex.org/keywords/maternal-and-fetal-outcomes","display_name":"maternal and fetal outcomes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C2780537801","wikidata":"https://www.wikidata.org/wiki/Q1563513","display_name":"HELLP syndrome","level":4,"score":0.9786311984062195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9366506338119507},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.6175358295440674},{"id":"https://openalex.org/C2781276381","wikidata":"https://www.wikidata.org/wiki/Q552348","display_name":"Eclampsia","level":3,"score":0.5173506140708923},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5037643313407898},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38700392842292786},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.3444499373435974},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3394958972930908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011295","descriptor_name":"Prenatal Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017359","descriptor_name":"HELLP Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D049590","descriptor_name":"Postpartum Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17505460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17505460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva ginecologica","raw_type":"Journal Article"},{"id":"mag:59880676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17505460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2286113666","https://openalex.org/W1888444958","https://openalex.org/W1764176278","https://openalex.org/W1973795002","https://openalex.org/W2065865183","https://openalex.org/W4400777723","https://openalex.org/W4400159179","https://openalex.org/W4388491337","https://openalex.org/W2112442583","https://openalex.org/W4410051553"],"abstract_inverted_index":{"The":[0,62,90,110,151],"fundamental":[1],"premise":[2],"that":[3,31,72],"has":[4],"governed":[5],"the":[6,10,15,54,66,82,192],"proposal":[7],"relative":[8],"to":[9,56,159],"use":[11],"of":[12,17,84,138,194],"corticosteroids":[13,52,73,125,178],"for":[14,121,127,179],"purpose":[16],"disease":[18,128,180],"modification":[19,129,181],"in":[20,48,98,113,130,182],"Hemolysis,":[21],"Elevated":[22],"Liver":[23],"Enzymes,":[24],"and":[25,44,59,103,117,132,146,148,169],"Low":[26],"Platelets":[27],"(HELLP)":[28],"syndrome":[29,142,186],"was":[30,119],"pre-eclampsia":[32,131],"is":[33],"a":[34,136],"condition":[35],"characterized":[36],"by":[37,87],"an":[38,95,195],"inappropriate":[39],"maternal":[40],"systemic":[41],"inflammatory":[42],"response":[43],"possibly":[45],"immune-mediated":[46],"impairment":[47],"maternal-fetal":[49],"communication,":[50],"while":[51],"have":[53],"capacity":[55],"exercise":[57],"anti-inflammatory":[58],"immunosuppressive":[60],"effects.":[61],"present":[63],"article":[64],"reviews":[65],"evidence":[67],"behind":[68],"this":[69,160],"proposal,":[70],"concluding":[71],"administration,":[74],"either":[75],"antepartum":[76],"or":[77],"postpartum,":[78],"does":[79],"not":[80,188],"improve":[81],"outcome":[83],"pregnancies":[85],"affected":[86],"HELLP":[88,133,185],"syndrome.":[89],"risks":[91],"associated":[92],"with":[93,124,184],"such":[94],"approach,":[96],"especially":[97],"fetuses":[99],"manifesting":[100],"growth":[101],"restriction":[102],"absent":[104],"end-diastolic":[105],"flow,":[106],"are":[107],"also":[108],"discussed.":[109],"literature":[111],"published":[112],"English":[114],"between":[115],"1990":[116],"2006":[118],"searched":[120],"papers":[122],"dealing":[123],"treatment":[126],"syndrome,":[134],"using":[135],"combination":[137],"keywords":[139],"including":[140,162],"''HELLP":[141],"'',":[143],"''pre-eclampsia'',":[144],"''corticosteroids'',":[145],"''maternal":[147],"fetal":[149],"outcomes''.":[150],"MEDLINE":[152],"bibliographic":[153],"database":[154],"yielded":[155],"9":[156],"studies":[157],"relevant":[158],"topic,":[161],"one":[163,170],"retrospective":[164],"analysis,":[165],"7":[166],"randomized":[167],"trials,":[168],"meta-analysis.":[171],"Until":[172],"more":[173],"convincing":[174],"data":[175],"become":[176],"available,":[177],"women":[183],"should":[187],"be":[189],"used":[190],"outside":[191],"setting":[193],"approved":[196],"investigational":[197],"protocol.":[198]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}