{"id":"https://openalex.org/W598708682","doi":"https://doi.org/10.1021/acsami.5b03879","title":"Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord Regeneration in Vivo","display_name":"Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord Regeneration in Vivo","publication_year":2015,"publication_date":"2015-06-02","ids":{"openalex":"https://openalex.org/W598708682","doi":"https://doi.org/10.1021/acsami.5b03879","mag":"598708682","pmid":"https://pubmed.ncbi.nlm.nih.gov/26034998"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.5b03879","doi":"https://doi.org/10.1021/acsami.5b03879","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.5b03879","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055105900","display_name":"Xing Li","orcid":"https://orcid.org/0000-0001-7146-0125","observed_orcids":["https://orcid.org/0000-0001-7146-0125","https://orcid.org/0009-0001-8036-1089"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Li","raw_affiliation_strings":["State\rKey Laboratory of Molecular Developmental Biology, Institute of Genetics\rand Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","University of Chinese Academy of Sciences, Beijing 100190, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State\rKey Laboratory of Molecular Developmental Biology, Institute of Genetics\rand Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100190, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057408888","display_name":"Jin Han","orcid":"https://orcid.org/0000-0001-8799-5140","observed_orcids":["https://orcid.org/0000-0001-8799-5140"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Han","raw_affiliation_strings":["State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101501520","display_name":"Yannan Zhao","orcid":"https://orcid.org/0000-0003-3240-1207","observed_orcids":["https://orcid.org/0000-0003-3240-1207"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yannan Zhao","raw_affiliation_strings":["State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102108433","display_name":"Wenyong Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyong Ding","raw_affiliation_strings":["Department\rof Biochemistry, Dalian Medical University, Dalian 116044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Biochemistry, Dalian Medical University, Dalian 116044, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103278952","display_name":"Jianshu Wei","orcid":"https://orcid.org/0000-0002-8716-570X","observed_orcids":["https://orcid.org/0000-0002-8716-570X","https://orcid.org/0000-0002-9778-7131"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianshu Wei","raw_affiliation_strings":["State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001098328","display_name":"Sufang Han","orcid":"https://orcid.org/0000-0002-5348-012X","observed_orcids":["https://orcid.org/0000-0002-5348-012X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sufang Han","raw_affiliation_strings":["State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049023394","display_name":"Xianping Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianping Shang","raw_affiliation_strings":["Department\rof Biochemistry, Dalian Medical University, Dalian 116044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Biochemistry, Dalian Medical University, Dalian 116044, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100639411","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0002-1348-1494","observed_orcids":["https://orcid.org/0000-0002-1348-1494"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Wang","raw_affiliation_strings":["State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443098","display_name":"Bing Chen","orcid":"https://orcid.org/0000-0002-1238-3948","observed_orcids":["https://orcid.org/0000-0002-1238-3948"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Chen","raw_affiliation_strings":["State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101528594","display_name":"Zhifeng Xiao","orcid":"https://orcid.org/0000-0001-8970-5565","observed_orcids":["https://orcid.org/0000-0001-8970-5565"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifeng Xiao","raw_affiliation_strings":["State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113986544","display_name":"Jianwu Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391768245","display_name":"State Key Laboratory of Molecular Developmental Biology","ror":"https://ror.org/04caj7738","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianwu Dai","raw_affiliation_strings":["State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113986544"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391768245"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1245,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.92022808,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":"25","first_page":"13960","last_page":"13971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-regeneration","display_name":"spinal cord regeneration","score":0.8330000042915344},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ephrin-b3","display_name":"ephrin-B3","score":0.9210000038146973},{"id":"https://openalex.org/keywords/sema4d","display_name":"Sema4D","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.8009999990463257},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.656000018119812},{"id":"https://openalex.org/keywords/nep1-40","display_name":"NEP1-40","score":0.8529999852180481},{"id":"https://openalex.org/keywords/collagen-binding-protein","display_name":"collagen-binding protein","score":0.5609999895095825},{"id":"https://openalex.org/keywords/locomotor-recovery","display_name":"locomotor recovery","score":0.6470000147819519},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7908953428268433},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.7747406959533691},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6352184414863586},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.6216873526573181},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5975271463394165},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.5753858089447021},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5586119890213013},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.5271199345588684},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4937923848628998},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4758205711841583},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.4659477472305298},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4638298749923706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32357752323150635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26618045568466187},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2546007037162781},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24963781237602234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19364604353904724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1384514570236206},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.13498744368553162},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036122","descriptor_name":"Receptor, EphA4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036122","descriptor_name":"Receptor, EphA4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058630","descriptor_name":"Spinal Cord Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058630","descriptor_name":"Spinal Cord Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.5b03879","doi":"https://doi.org/10.1021/acsami.5b03879","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.5b03879","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},{"id":"pmid:26034998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26034998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3537808844","display_name":null,"funder_award_id":"2014CB965003","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G5810208063","display_name":null,"funder_award_id":"XDA01030000","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G7024332431","display_name":null,"funder_award_id":"2012AA020501","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G7042690677","display_name":null,"funder_award_id":"51361130033","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7328982269","display_name":null,"funder_award_id":"2013AA020106","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G7707684810","display_name":null,"funder_award_id":"2011CB965001","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1560041527","https://openalex.org/W1974432822","https://openalex.org/W1975724680","https://openalex.org/W1983712592","https://openalex.org/W1983891257","https://openalex.org/W1986279004","https://openalex.org/W1989418404","https://openalex.org/W1994565600","https://openalex.org/W1997325127","https://openalex.org/W2001027721","https://openalex.org/W2003802768","https://openalex.org/W2013405371","https://openalex.org/W2020340848","https://openalex.org/W2020850411","https://openalex.org/W2022242829","https://openalex.org/W2023371306","https://openalex.org/W2035120744","https://openalex.org/W2038966527","https://openalex.org/W2041728734","https://openalex.org/W2042862506","https://openalex.org/W2054201119","https://openalex.org/W2059787923","https://openalex.org/W2072821348","https://openalex.org/W2079835022","https://openalex.org/W2080215345","https://openalex.org/W2081968410","https://openalex.org/W2100057436","https://openalex.org/W2129588435","https://openalex.org/W2132424160","https://openalex.org/W2141793003","https://openalex.org/W2145986561","https://openalex.org/W2155126659","https://openalex.org/W2162769562","https://openalex.org/W2164525290"],"related_works":["https://openalex.org/W2174215545","https://openalex.org/W2568379729","https://openalex.org/W2003802768","https://openalex.org/W2090754165","https://openalex.org/W2042862506","https://openalex.org/W3090268524","https://openalex.org/W2080215345","https://openalex.org/W3144799616","https://openalex.org/W3129100712","https://openalex.org/W2079835022"],"abstract_inverted_index":{"Research":[0],"has":[1],"demonstrated":[2],"that":[3,52,123,125],"many":[4],"myelin-associated":[5],"inhibitory":[6,23],"molecules":[7,48],"jointly":[8],"contribute":[9],"to":[10,43,67,72],"the":[11,21,26,45,54,96,127,131],"failure":[12],"of":[13,25,56,84,129],"adult":[14],"spinal":[15,28,116,145],"cord":[16,29,117,146],"regeneration.":[17],"Therapies":[18],"comprehensively":[19],"targeting":[20],"multiple":[22],"nature":[24],"injured":[27],"are":[30],"being":[31],"concerned.":[32],"Here,":[33],"two":[34,60],"collagen-binding":[35],"proteins,":[36],"CBD-EphA4LBD":[37,106],"and":[38,50,71,88,104,107,141],"CBD-PlexinB1LBD,":[39],"were":[40,109],"constructed,":[41],"respectively,":[42],"neutralize":[44],"axon":[46],"guidance":[47],"ephrinB3":[49],"sema4D":[51],"inhibit":[53],"regeneration":[55,140],"nerve":[57],"fibers.":[58],"The":[59],"neutralizing":[61],"proteins":[62],"have":[63],"proven":[64],"their":[65],"ability":[66],"specifically":[68],"bind":[69],"collagen":[70,76,98,133],"continuously":[73],"release":[74],"from":[75],"scaffolds.":[77],"They":[78],"could":[79],"also":[80],"promote":[81],"neurites":[82],"outgrowth":[83],"cerebellar":[85],"granular":[86],"neurons":[87,92],"dorsal":[89],"root":[90],"ganglion":[91],"in":[93],"vitro.":[94],"Subsequently,":[95],"functionalized":[97,132],"scaffolds":[99],"by":[100],"physically":[101],"absorbing":[102],"NEP1-40":[103],"immobilizing":[105],"CBD-PlexinB1LBD":[108],"transplanted":[110],"into":[111],"a":[112],"rat":[113],"T10":[114],"complete":[115],"transection":[118],"model.":[119],"Our":[120],"results":[121],"showed":[122],"rats":[124],"received":[126],"treatment":[128],"transplanting":[130],"scaffold":[134],"exhibited":[135],"great":[136],"advantage":[137],"on":[138],"axonal":[139],"locomotion":[142],"recovery":[143],"after":[144],"injury.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}