{"id":"https://openalex.org/W598682979","doi":null,"title":"Mutational analysis of the Guanine Nucleotide Exchange Factor C3G in Drosophila melanogaster reveals a role for C3G in larval muscle development.","display_name":"Mutational analysis of the Guanine Nucleotide Exchange Factor C3G in Drosophila melanogaster reveals a role for C3G in larval muscle development.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W598682979","mag":"598682979"},"language":"en","primary_location":{"id":"mag:598682979","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:212877","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005107515","display_name":"Margret Shirinian","orcid":"https://orcid.org/0000-0003-4666-2758","observed_orcids":["https://orcid.org/0000-0003-4666-2758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margret Shirinian","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4666-2758","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007263489","display_name":"Gaurav K. Varshney","orcid":"https://orcid.org/0000-0002-0429-1904","observed_orcids":["https://orcid.org/0000-0002-0429-1904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaurav K. Varshney","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0429-1904","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007977575","display_name":"Ruth Helen Palmer","orcid":"https://orcid.org/0000-0002-2735-8470","observed_orcids":["https://orcid.org/0000-0002-2735-8470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth H. Palmer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2735-8470","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04371157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c3g","display_name":"C3G","score":0.9010000228881836},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/smooth-muscle","display_name":"smooth muscle","score":0.5270000100135803},{"id":"https://openalex.org/keywords/midgut","display_name":"midgut","score":0.6259999871253967},{"id":"https://openalex.org/keywords/alk-receptor-tyrosine-kinase","display_name":"ALK receptor tyrosine kinase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/founder-cells","display_name":"founder cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/myoblast-fusion","display_name":"myoblast fusion","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dpp-signaling","display_name":"Dpp signaling","score":0.5770000219345093},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.6430000066757202},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.9344042539596558},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.8162460923194885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7826871275901794},{"id":"https://openalex.org/C191548132","wikidata":"https://www.wikidata.org/wiki/Q2355306","display_name":"Histogenesis","level":3,"score":0.6199581027030945},{"id":"https://openalex.org/C63101894","wikidata":"https://www.wikidata.org/wiki/Q604095","display_name":"Fate mapping","level":4,"score":0.5188035368919373},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5134928822517395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4423941671848297},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.4147905111312866},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37109923362731934},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3196384310722351},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15408951044082642},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0999268889427185},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:598682979","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:212877","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097667073","https://openalex.org/W2163375761","https://openalex.org/W6963381076","https://openalex.org/W2060863019","https://openalex.org/W2170677464","https://openalex.org/W253796135","https://openalex.org/W2060909091","https://openalex.org/W1994889979","https://openalex.org/W2156574327","https://openalex.org/W567699116"],"abstract_inverted_index":{"The":[0,16,39,68,144,245],"fully":[1],"developed":[2],"and":[3,13,44,48,74,84,150,239,251,269,342,430],"functional":[4],"Drosophila":[5,410],"midgut":[6,21,53,363],"comprises":[7],"two":[8,306],"layers,":[9],"the":[10,14,20,25,36,46,49,52,58,71,82,85,89,94,116,120,126,129,135,147,154,189,199,234,237,240,267,272,283,292,305,333,339,344,359,362,371,382,402,409,415],"visceral":[11,17,72,95,130,148,175,190,241,273,284,300,319,345,403],"mesoderm":[12,96,285],"endoderm.":[15],"muscle":[18,37,54,73,149,176,191,242,274,301,320,346,404,455],"of":[19,27,41,51,88,119,128,146,188,198,248,271,282,291,299,335,361,408,417,435],"is":[22,55,75,122,156,193,216,314,394,441],"formed":[23,76],"by":[24,366,391,450],"fusion":[26,31,47,252,258],"founder":[28,249,340,383,405],"cells":[29,33,43,78,92,250,341],"with":[30],"competent":[32,253,385],"to":[34,184,218,231,332,378],"form":[35],"syncytia.":[38],"specification":[40,247],"these":[42],"thus":[45],"formation":[50],"dependent":[56],"on":[57,153],"Receptor":[59],"tyrosine":[60],"kinase":[61],"(RTK)":[62],"Alk":[63,104,313,324,336,352],"(Loren":[64],"et":[65],"al.,":[66],"2003).":[67],"endoderm":[69,110,121,155,224,238,287,293],"underlies":[70],"from":[77,81],"that":[79,134,351,387,439],"originate":[80],"anterior":[83],"posterior":[86],"parts":[87],"embryo.":[90],"These":[91],"use":[93],"as":[97,204,255,257,278],"a":[98,169,205,208,296,315,356,395],"substrate":[99],"for":[100,172,195,327,443],"their":[101,185],"migration.":[102],"Using":[103],"mutant":[105,164,325],"animals,":[106,165],"we":[107,132,322,348,376],"have":[108,160,219,349],"studied":[109],"migration":[111,118,139],"during":[112,243],"embryonic":[113,373],"development.":[114,225,244],"While":[115],"initial":[117,246],"not":[123,141,276],"affected":[124],"in":[125,168,207,223,262,295,310,318,337,358,370,381,401,414,420,448],"absence":[127],"mesoderm,":[131],"observe":[133],"later":[136],"dorsal-ventral":[137],"endodermal":[138],"does":[140,275],"take":[142],"place.":[143],"development":[145],"its":[151],"dependence":[152],"poorly":[157],"understood.":[158],"We":[159],"analysed":[161],"gurtelchen":[162],"(gurt)":[163],"originally":[166],"identified":[167,202],"genetic":[170],"screen":[171],"mutations":[173],"affecting":[174],"formation.":[177,302],"Gurt":[178,226],"mutants":[179,228,419,437],"are":[180,260,423,431],"so":[181],"named":[182],"due":[183],"belt-like":[186],"phenotype":[187],"(gurtelchen":[192],"German":[194],"belt).":[196],"Mapping":[197],"genomic":[200],"locus":[201,412],"gurt":[203,263],"mutation":[206],"previously":[209],"described":[210],"gene":[211],"-":[212],"huckebein":[213],"(hkb)":[214,227,264],"which":[215,422],"known":[217],"an":[220],"important":[221],"function":[222],"were":[229],"used":[230],"further":[232],"study":[233],"interaction":[235],"between":[236,304],"myoblasts":[254,386],"well":[256],"events":[259],"unaffected":[261],"mutants,":[265],"however,":[266],"elongation":[268],"stretching":[270],"proceed":[277],"normal.":[279],"Moreover,":[280],"ablation":[281,290],"disrupts":[286],"migration,":[288],"while":[289],"results":[294],"delayed":[297],"disruption":[298],"Signaling":[303],"tissues":[307],"was":[308],"investigated":[309],"detail.":[311],"Since":[312],"critical":[316],"player":[317],"development,":[321,447],"employed":[323],"embryos":[326],"this":[328],"task.":[329],"In":[330],"addition":[331],"role":[334,357],"specifying":[338],"initiating":[343],"fusion,":[347],"shown":[350],"mediated":[353],"signaling":[354],"has":[355],"induction":[360],"constriction":[364],"process":[365],"regulating":[367,451],"dpp":[368],"expression":[369],"developing":[372],"gut.":[374],"Finally,":[375],"wished":[377],"identify":[379],"genes":[380],"cells/fusion":[384],"might":[388],"be":[389],"regulated":[390],"Alk.":[392],"C3G":[393,411,421,436,440],"gunaine":[396],"nucleotide":[397],"exchange":[398],"factor":[399],"expressed":[400],"cells.":[406],"Deletion":[407],"resulted":[413],"generation":[416],"null":[418],"viable,":[424],"but":[425],"display":[426],"decreased":[427],"longevity,":[428],"fitness":[429],"semi-lethal.":[432],"Further":[433],"analysis":[434],"indicated":[438],"essential":[442],"normal":[444],"larval":[445],"musculature":[446],"part":[449],"integrin":[452],"localization":[453],"at":[454],"attachment":[456],"sites.":[457]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}