{"id":"https://openalex.org/W597609891","doi":null,"title":"Pathophysiological impact of targeting the ROS-p53 axis","display_name":"Pathophysiological impact of targeting the ROS-p53 axis","publication_year":2014,"publication_date":"2014-10-21","ids":{"openalex":"https://openalex.org/W597609891","mag":"597609891"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/36746","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/36746","pdf_url":"http://hdl.handle.net/2077/36746","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/36746","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076143617","display_name":"Volkan I. Sayin","orcid":"https://orcid.org/0000-0002-5225-8260","observed_orcids":["https://orcid.org/0000-0002-5225-8260"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Volkan I. Sayin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5225-8260","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076143617"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9359999895095825},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lung-cancer-progression","display_name":"lung cancer progression","score":0.8360000252723694},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5339999794960022},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8460000157356262},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.6190000176429749},{"id":"https://openalex.org/keywords/lung-development","display_name":"lung development","score":0.6990000009536743},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8370000123977661},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6303691864013672},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5471063256263733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4547225832939148},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43200722336769104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.383797824382782},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37745440006256104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.304379403591156}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/36746","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/36746","pdf_url":"http://hdl.handle.net/2077/36746","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:597609891","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/36746/2/gupea_2077_36746_2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/36746","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/36746","pdf_url":"http://hdl.handle.net/2077/36746","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W597609891.pdf","grobid_xml":"https://content.openalex.org/works/W597609891.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W10635023","https://openalex.org/W1525444530","https://openalex.org/W1595293335","https://openalex.org/W1598779357","https://openalex.org/W1650797637","https://openalex.org/W1657827244","https://openalex.org/W1678580492","https://openalex.org/W1756908435","https://openalex.org/W1792024194","https://openalex.org/W1965009601","https://openalex.org/W1965749441","https://openalex.org/W1967287827","https://openalex.org/W1967411041","https://openalex.org/W1967528766","https://openalex.org/W1967880683","https://openalex.org/W1969044026","https://openalex.org/W1969526991","https://openalex.org/W1976816889","https://openalex.org/W1986377088","https://openalex.org/W1990095100","https://openalex.org/W1990606472","https://openalex.org/W1990797461","https://openalex.org/W1995049749","https://openalex.org/W1997685333","https://openalex.org/W1998560601","https://openalex.org/W1998931004","https://openalex.org/W1999563094","https://openalex.org/W2000673132","https://openalex.org/W2001258296","https://openalex.org/W2006314834","https://openalex.org/W2010832415","https://openalex.org/W2017757397","https://openalex.org/W2021517975","https://openalex.org/W2023975001","https://openalex.org/W2024028136","https://openalex.org/W2025722611","https://openalex.org/W2027146979","https://openalex.org/W2032906278","https://openalex.org/W2034269086","https://openalex.org/W2036761446","https://openalex.org/W2037755687","https://openalex.org/W2038970416","https://openalex.org/W2043281296","https://openalex.org/W2046780997","https://openalex.org/W2046990478","https://openalex.org/W2049151505","https://openalex.org/W2049980919","https://openalex.org/W2050389860","https://openalex.org/W2057060764","https://openalex.org/W2057830803","https://openalex.org/W2059566565","https://openalex.org/W2064190260","https://openalex.org/W2067480394","https://openalex.org/W2072569792","https://openalex.org/W2073331259","https://openalex.org/W2078581194","https://openalex.org/W2085243691","https://openalex.org/W2085848981","https://openalex.org/W2088420183","https://openalex.org/W2091723114","https://openalex.org/W2092685208","https://openalex.org/W2093116072","https://openalex.org/W2094655287","https://openalex.org/W2095301528","https://openalex.org/W2096276671","https://openalex.org/W2096751224","https://openalex.org/W2098942721","https://openalex.org/W2107079238","https://openalex.org/W2109193464","https://openalex.org/W2113252276","https://openalex.org/W2116885418","https://openalex.org/W2117035050","https://openalex.org/W2117692326","https://openalex.org/W2118446959","https://openalex.org/W2123160603","https://openalex.org/W2134208169","https://openalex.org/W2141638474","https://openalex.org/W2144104488","https://openalex.org/W2144411286","https://openalex.org/W2150097377","https://openalex.org/W2150930051","https://openalex.org/W2151782814","https://openalex.org/W2154101400","https://openalex.org/W2157032821","https://openalex.org/W2158777030","https://openalex.org/W2159449551","https://openalex.org/W2160750179","https://openalex.org/W2161771297","https://openalex.org/W2167674778","https://openalex.org/W2187379309","https://openalex.org/W2337788552","https://openalex.org/W7075739058"],"related_works":["https://openalex.org/W2010077871","https://openalex.org/W2154553542","https://openalex.org/W2056270397","https://openalex.org/W2059474909","https://openalex.org/W13599526","https://openalex.org/W3007389146","https://openalex.org/W7098738319","https://openalex.org/W1976774441","https://openalex.org/W1591491536","https://openalex.org/W7099790848"],"abstract_inverted_index":{"The":[0,190],"goal":[1],"of":[2,11,22,66,76,109,119,124,137,145,148,159,180,192,219],"this":[3,33],"PhD":[4],"thesis":[5],"was":[6],"to":[7,90,209],"define":[8],"the":[9,12,23,64,74,83,97,134,142,176,206],"importance":[10],"interplay":[13],"between":[14],"reactive":[15],"oxygen":[16],"species":[17],"(ROS)":[18],"and":[19,29,38,45,63,78,86,127,140,153,167,178,184,227],"their":[20],"activation":[21,111],"tumor":[24,151],"suppressor":[25,108],"p53":[26,84,110,120,149,160,231],"in":[27,61,133,141,164,196,225],"development":[28,152],"disease.":[30],"We":[31],"addressed":[32],"question":[34],"using":[35],"molecular":[36],"biology":[37],"biochemical":[39],"techniques":[40],"together":[41],"with":[42,188,198],"mouse":[43],"genetics":[44],"bioinformatics.\\nWe":[46],"have":[47,222],"made":[48],"two":[49],"important":[50,162],"discoveries:\\nFirst,":[51],"we":[52,94],"show":[53,95],"that":[54,96],"antioxidant":[55,207],"supplementation":[56,173],"accelerates":[57],"lung":[58,68,116,130,182,194],"cancer":[59,69,88,139,195,226],"progression":[60,179],"mice":[62],"growth":[65,92,122,177],"human":[67],"cell":[70],"lines.":[71],"By":[72],"reducing":[73],"levels":[75],"ROS":[77],"DNA":[79],"damage,":[80],"antioxidants":[81],"deactivate":[82],"protein":[85,102],"help":[87],"cells":[89,126],"evade":[91],"arrest.\\nSecond,":[93],"transcription":[98],"factor":[99],"zinc":[100],"finger":[101],"148":[103],"(Zfp148)":[104],"is":[105],"a":[106],"potent":[107],"under":[112],"oxidative":[113],"conditions.":[114],"During":[115],"development,":[117],"suppression":[118,147,158],"prevents":[121],"arrest":[123],"pulmonary":[125,201],"permits":[128],"prenatal":[129],"maturation.":[131],"However,":[132],"ApcMin/+":[135],"model":[136,144],"colorectal":[138],"Apoe\u2013/\u2013":[143],"atherosclerosis,":[146,154],"promotes":[150],"respectively.":[155],"Thus":[156],"Zfp148":[157,220],"plays":[161],"roles":[163],"both":[165],"physiological":[166],"pathological":[168],"contexts.\\nWe":[169],"conclude":[170],"that:\\n1)":[171],"Antioxidant":[172],"may":[174,221],"stimulate":[175],"undiagnosed":[181],"tumors":[183],"should":[185,213],"be":[186,214],"used":[187],"caution.":[189],"risk":[191],"developing":[193],"patients":[197],"chronic":[199],"obstructive":[200],"disease":[202],"(COPD)":[203],"who":[204],"take":[205],"acetylcysteine":[208],"break":[210],"down":[211],"mucus":[212],"carefully":[215],"evaluated.\\n2)":[216],"Therapeutic":[217],"targeting":[218],"beneficial":[223],"effects":[224],"atherosclerosis":[228],"by":[229],"increasing":[230],"activity.":[232]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}