{"id":"https://openalex.org/W59752764","doi":"https://doi.org/10.1096/fasebj.21.5.a618-a","title":"The Catalytic Subunit of Protein Phosphatase 2A is a Highly Sensitive Target of Protein Disulfide\u2010Mediated Oxidative Stress","display_name":"The Catalytic Subunit of Protein Phosphatase 2A is a Highly Sensitive Target of Protein Disulfide\u2010Mediated Oxidative Stress","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W59752764","doi":"https://doi.org/10.1096/fasebj.21.5.a618-a","mag":"59752764"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a618-a","doi":"https://doi.org/10.1096/fasebj.21.5.a618-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a618-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073319805","display_name":"Timothy D. Foley","orcid":"https://orcid.org/0000-0002-2378-0703","observed_orcids":["https://orcid.org/0000-0002-2378-0703"]},"institutions":[{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy D Foley","raw_affiliation_strings":["Chemistry University of Scranton 800 Linden St Scranton PA 18510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry University of Scranton 800 Linden St Scranton PA 18510","institution_ids":["https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012315723","display_name":"Coral M. Stredny","orcid":"https://orcid.org/0000-0003-1176-640X","observed_orcids":["https://orcid.org/0000-0003-1176-640X"]},"institutions":[{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Coral M Stredny","raw_affiliation_strings":["Chemistry University of Scranton 800 Linden St Scranton PA 18510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry University of Scranton 800 Linden St Scranton PA 18510","institution_ids":["https://openalex.org/I124113063"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087979632","display_name":"Teresa M. Coppa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa Coppa","raw_affiliation_strings":["Chemistry University of Scranton 800 Linden St Scranton PA 18510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry University of Scranton 800 Linden St Scranton PA 18510","institution_ids":["https://openalex.org/I124113063"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I124113063"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00681123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-2a","display_name":"protein phosphatase 2A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/catalytic-subunit","display_name":"catalytic subunit","score":0.9070000052452087},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7319999933242798},{"id":"https://openalex.org/keywords/disulfide-bond-formation","display_name":"disulfide bond formation","score":0.734000027179718},{"id":"https://openalex.org/keywords/thiol-oxidation","display_name":"thiol oxidation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7300000190734863},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/snap-25","display_name":"SNAP-25","score":0.8709999918937683},{"id":"https://openalex.org/keywords/protein-complexes","display_name":"protein complexes","score":0.47099998593330383},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.8824185729026794},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7562334537506104},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.720329999923706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6689108610153198},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.6273831129074097},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6130379438400269},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5989019870758057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5652251243591309},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2697627544403076},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a618-a","doi":"https://doi.org/10.1096/fasebj.21.5.a618-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a618-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.41999998688697815,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980193768","https://openalex.org/W7064716503","https://openalex.org/W2014116614","https://openalex.org/W1979656297","https://openalex.org/W7038216254","https://openalex.org/W6991688684","https://openalex.org/W2139305993","https://openalex.org/W2044136163","https://openalex.org/W2011197100","https://openalex.org/W2465901958"],"abstract_inverted_index":{"Mounting":[0],"evidence":[1],"suggests":[2],"that":[3,24,46,88,187,205],"protein":[4,158,169,199],"phosphatase":[5],"2A":[6],"(PP2A),":[7],"a":[8,33,73,84,179,194],"key":[9],"regulator":[10],"of":[11,19,28,35,42,53,58,86,95,122,129,136,150,170,191,198,209,217],"neuronal":[12],"function,":[13],"may":[14,31,48,212],"be":[15,32],"an":[16,110],"important":[17],"target":[18,197],"disulfide\u2010mediated":[20,200],"oxidative":[21,36,64,116,201,218],"stress":[22,65,117,202],"and":[23,50,139,147,203],"thiol":[25,123],"oxidation\u2010based":[26,127],"inhibition":[27,57,128],"PP2A":[29,47,59,87,130,151,176,192],"activity":[30,60],"cause":[34],"stress\u2010induced":[37],"neurotoxicity.":[38],"However,":[39],"the":[40,43,51,89,96,106,114,120,134,148,164,167,188,206,215],"nature":[41],"physiologically\u2010relevant":[44],"disulfides":[45,101],"form":[49],"relationship":[52],"disulfide":[54,112,145,181,210],"formation":[55,211],"to":[56,63],"in":[61,119],"response":[62],"remain":[66],"unclear.":[67],"The":[68],"present":[69],"results":[70,185],"demonstrate":[71,186],"using":[72],"high":[74,155],"molecular":[75,156],"weight":[76,157],"soluble":[77],"fraction":[78],"(HMWSF)":[79],"from":[80,105,163],"rat":[81],"brain":[82,107],"as":[83],"source":[85],"catalytic":[90,189],"subunit":[91,190],"(PP2A":[92],"C":[93,152,177],")":[94],"enzyme":[97],"readily":[98],"formed":[99,178],"intermolecular":[100],"with":[102,142,182],"other":[103,161],"proteins":[104,162],"and,":[108],"perhaps,":[109],"intramolecular":[111],"under":[113],"mild":[115],"achieved":[118],"absence":[121],"reducing":[124],"agent.":[125],"Thiol":[126],"activity,":[131],"however,":[132],"required":[133],"addition":[135],"hydrogen":[137],"peroxide":[138],"was":[140],"associated":[141],"more":[143],"extensive":[144],"cross\u2010linking":[146],"incorporation":[149],"into":[153],"very":[154],"complexes.":[159],"Notably,":[160],"HMWSF,":[165],"including":[166],"synaptosomal\u2010associated":[168],"25":[171],"kDa":[172],"(SNAP\u201025),":[173],"but":[174],"not":[175],"mixed":[180],"biotinyl\u2010glutathione.":[183],"These":[184],"is":[193],"highly":[195],"sensitive":[196],"suggest":[204],"functional":[207],"consequences":[208],"depend":[213],"on":[214],"level":[216],"stress.":[219]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}