{"id":"https://openalex.org/W59648168","doi":null,"title":"The nature of the natural killer (NK) cell of human intestinal mucosa and mesenteric lymph node.","display_name":"The nature of the natural killer (NK) cell of human intestinal mucosa and mesenteric lymph node.","publication_year":1985,"publication_date":"1985-07-01","ids":{"openalex":"https://openalex.org/W59648168","mag":"59648168","pmid":"https://pubmed.ncbi.nlm.nih.gov/2412737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577248"},"language":"en","primary_location":{"id":"pmid:2412737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2412737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1577248/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038423820","display_name":"Peter G. Gibson","orcid":"https://orcid.org/0000-0001-5865-489X","observed_orcids":["https://orcid.org/0000-0001-5865-489X"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P R Gibson","raw_affiliation_strings":["Radcliffe Infirmary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radcliffe Infirmary","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108412159","display_name":"Derek P. Jewell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D P Jewell","raw_affiliation_strings":["Radcliffe Infirmary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radcliffe Infirmary","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4539,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.57887065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"1","first_page":"160","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intestinal-mucosa","display_name":"intestinal mucosa","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mesenteric-lymph-nodes","display_name":"mesenteric lymph nodes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mononuclear-cells","display_name":"mononuclear cells","score":0.7829999923706055},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lymphoblastoid-interferon","display_name":"lymphoblastoid interferon","score":0.8849999904632568},{"id":"https://openalex.org/keywords/complement-mediated-cell-lysis","display_name":"complement-mediated lysis","score":0.6819999814033508},{"id":"https://openalex.org/keywords/nk-cell-precursors","display_name":"NK cell precursors","score":0.6729999780654907},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.7960000038146973},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6869999766349792},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nordihydroguaiaretic-acid","display_name":"nordihydroguaiaretic acid","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.7490000128746033},{"id":"https://openalex.org/keywords/lipoxygenase","display_name":"lipoxygenase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/macrophage-depletion","display_name":"macrophage depletion","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5801838636398315},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.5736872553825378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5678488612174988},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5507661700248718},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5294285416603088},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.5151656866073608},{"id":"https://openalex.org/C2776889390","wikidata":"https://www.wikidata.org/wiki/Q7050774","display_name":"Nordihydroguaiaretic acid","level":4,"score":0.49247416853904724},{"id":"https://openalex.org/C2779237934","wikidata":"https://www.wikidata.org/wiki/Q7643652","display_name":"Mesenteric lymph nodes","level":3,"score":0.4763469994068146},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.46917277574539185},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.42092105746269226},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.33502593636512756},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2728903889656067},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24451962113380432},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22156789898872375},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.22056859731674194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2089638113975525},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.1475188434123993},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10136786103248596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07394835352897644}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007410","descriptor_name":"Intestinal Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009637","descriptor_name":"Masoprocol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011459","descriptor_name":"Prostaglandins E, Synthetic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:2412737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2412737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1577248","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1577248/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"mag:59648168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2412737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1577248","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1577248/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1549587599","https://openalex.org/W1585835155","https://openalex.org/W1597297458","https://openalex.org/W1786228688","https://openalex.org/W1898713645","https://openalex.org/W1917376276","https://openalex.org/W1935482302","https://openalex.org/W1969861792","https://openalex.org/W1974954844","https://openalex.org/W1994467802","https://openalex.org/W1996219139","https://openalex.org/W2003801599","https://openalex.org/W2007232136","https://openalex.org/W2037849908","https://openalex.org/W2072554190","https://openalex.org/W2087847435","https://openalex.org/W2106059483","https://openalex.org/W2131874825","https://openalex.org/W2241390467","https://openalex.org/W2337954569","https://openalex.org/W2399978833","https://openalex.org/W2412858175","https://openalex.org/W2413973395","https://openalex.org/W2416460292","https://openalex.org/W2418827088","https://openalex.org/W4313310658"],"related_works":["https://openalex.org/W1833012631","https://openalex.org/W2007232136","https://openalex.org/W1645362680","https://openalex.org/W2413305885","https://openalex.org/W1974954844","https://openalex.org/W2336387791","https://openalex.org/W2114891836","https://openalex.org/W2010344744","https://openalex.org/W2418827088","https://openalex.org/W2121400836"],"abstract_inverted_index":{"The":[0,79],"relationship":[1],"of":[2,20,27,44,64,84,106,111,127,137,154,165,205,212,222],"the":[3,32,37,134,146,172,209],"mononuclear":[4],"cell":[5,224],"(MNC)":[6],"from":[7,145],"human":[8],"intestinal":[9,53,117,166,178,190,230],"mucosa":[10],"and":[11,47,86,118,139,167,179,200],"mesenteric":[12,68],"lymph":[13,69],"node":[14,70],"mediating":[15],"anti-K-562":[16,187],"activity":[17,57,72,83,121,144,156,164,183,188],"with":[18,92,108,157,197],"that":[19,36,63,98,126,219],"peripheral":[21,65,100,128,168,180,206],"blood":[22,66,101,129,169,181],"has":[23],"been":[24],"assessed.":[25],"Depletion":[26],"macrophages":[28],"did":[29],"not":[30],"alter":[31],"measured":[33],"cytotoxicity":[34],"confirming":[35],"effector":[38],"cells":[39,51,196,215],"were":[40,149],"lymphocytes.":[41],"Complement":[42],"lysis":[43],"Leu":[45,48],"7":[46],"11b":[49],"coated":[50],"reduced":[52],"natural":[54],"killer":[55],"(NK)":[56],"by":[58,189,194],"a":[59,76],"similar":[60,96,198],"degree":[61],"to":[62,75,89,97,124,203,216],"but":[67,122],"NK":[71,82,120,143,163,182,195,214,223],"was":[73,95],"affected":[74],"lesser":[77],"extent.":[78],"response":[80],"in":[81,229],"mucosal":[85,213],"nodal":[87,119],"MNC":[88,107,170,191,231],"short":[90],"incubation":[91,105],"lymphoblastoid":[93],"interferon":[94],"for":[99],"MNC.":[102,130],"Twenty-four":[103],"hours":[104],"low":[109],"concentrations":[110],"purified":[112],"interleukin-2":[113],"(IL-2)":[114],"consistently":[115],"augmented":[116],"failed":[123],"augment":[125],"No":[131],"differences":[132],"between":[133],"inhibitory":[135],"effects":[136],"cAMP":[138],"prostaglandin":[140],"E2":[141],"on":[142,162],"three":[147],"sites":[148],"seen.":[150],"In":[151,185],"addition,":[152],"inhibition":[153],"cyclo-oxygenase":[155],"indomethacin":[158],"had":[159],"no":[160],"effect":[161],"while":[171],"lipoxygenase":[173],"inhibitor,":[174],"nordihydroguaiaretic":[175],"acid,":[176],"suppressed":[177],"similarly.":[184],"conclusion,":[186],"is":[192],"mediated":[193],"phenotypic":[199],"functional":[201],"properties":[202],"those":[204],"blood.":[207],"However,":[208],"increased":[210],"sensitivity":[211],"IL-2":[217],"suggests":[218],"higher":[220],"proportions":[221],"precursors":[225],"may":[226],"be":[227],"present":[228],"populations.":[232]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}