{"id":"https://openalex.org/W596041387","doi":null,"title":"The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy","display_name":"The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W596041387","mag":"596041387"},"language":"en","primary_location":{"id":"mag:596041387","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:488170","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028392882","display_name":"Malou Friederich Persson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Malou Friederich Persson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028392882"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5849999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5849999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.3747999966144562,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ucp2","display_name":"UCP2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.6740000247955322},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2779406938","wikidata":"https://www.wikidata.org/wiki/Q24720289","display_name":"Uncoupling protein","level":4,"score":0.8491865396499634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.650357723236084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6322770118713379},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5960956811904907},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5330221652984619},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.506902277469635},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4952200949192047},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.4335160553455353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41920045018196106},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3569541573524475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21489888429641724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19374001026153564},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.09831994771957397},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:596041387","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:488170","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W57120418","https://openalex.org/W1490491630","https://openalex.org/W1496187500","https://openalex.org/W1504214484","https://openalex.org/W1529592271","https://openalex.org/W1542041608","https://openalex.org/W1586163533","https://openalex.org/W1594539479","https://openalex.org/W1674844815","https://openalex.org/W1831673877","https://openalex.org/W1849649569","https://openalex.org/W1849928642","https://openalex.org/W1964936390","https://openalex.org/W1969735455","https://openalex.org/W1972011552","https://openalex.org/W1975551314","https://openalex.org/W1975876686","https://openalex.org/W1976589215","https://openalex.org/W1977949985","https://openalex.org/W1981387108","https://openalex.org/W1983856470","https://openalex.org/W1983872288","https://openalex.org/W1986497924","https://openalex.org/W1987639430","https://openalex.org/W1990549067","https://openalex.org/W1996269872","https://openalex.org/W1996324277","https://openalex.org/W1999159221","https://openalex.org/W2001565942","https://openalex.org/W2006635347","https://openalex.org/W2007819480","https://openalex.org/W2011786942","https://openalex.org/W2013401989","https://openalex.org/W2015452872","https://openalex.org/W2020267609","https://openalex.org/W2022983363","https://openalex.org/W2023530279","https://openalex.org/W2024218799","https://openalex.org/W2025152430","https://openalex.org/W2028132430","https://openalex.org/W2029818480","https://openalex.org/W2035637304","https://openalex.org/W2035810126","https://openalex.org/W2036573181","https://openalex.org/W2039194561","https://openalex.org/W2040921324","https://openalex.org/W2045838525","https://openalex.org/W2059182705","https://openalex.org/W2061166531","https://openalex.org/W2063016600","https://openalex.org/W2063945875","https://openalex.org/W2072522516","https://openalex.org/W2072546908","https://openalex.org/W2075462691","https://openalex.org/W2087561593","https://openalex.org/W2089707588","https://openalex.org/W2092823267","https://openalex.org/W2094655287","https://openalex.org/W2096712675","https://openalex.org/W2108189618","https://openalex.org/W2109312341","https://openalex.org/W2109566112","https://openalex.org/W2114212244","https://openalex.org/W2115337518","https://openalex.org/W2116094406","https://openalex.org/W2118683198","https://openalex.org/W2121338998","https://openalex.org/W2128569391","https://openalex.org/W2128802756","https://openalex.org/W2133595737","https://openalex.org/W2136498140","https://openalex.org/W2141950542","https://openalex.org/W2145398823","https://openalex.org/W2146965330","https://openalex.org/W2154682611","https://openalex.org/W2154768987","https://openalex.org/W2155931459","https://openalex.org/W2156172044","https://openalex.org/W2157600173","https://openalex.org/W2158458517","https://openalex.org/W2159258864","https://openalex.org/W2159691173","https://openalex.org/W2160331251","https://openalex.org/W2164945237","https://openalex.org/W2165096496","https://openalex.org/W2165623186","https://openalex.org/W2167064714","https://openalex.org/W2168033876","https://openalex.org/W2170355346","https://openalex.org/W2171211849","https://openalex.org/W2174121794","https://openalex.org/W2247806974","https://openalex.org/W2282325610","https://openalex.org/W2297568899","https://openalex.org/W2315512556","https://openalex.org/W2317242858","https://openalex.org/W2324579467","https://openalex.org/W2769264260"],"related_works":["https://openalex.org/W1544234823","https://openalex.org/W2041235216","https://openalex.org/W7101042369","https://openalex.org/W275085258","https://openalex.org/W1565367515","https://openalex.org/W2059702103","https://openalex.org/W2084502320","https://openalex.org/W2111076911","https://openalex.org/W2791693089","https://openalex.org/W363036939"],"abstract_inverted_index":{"Kidney":[0,85],"uncoupling":[1,115],"protein":[2,44,69],"2":[3,72],"(UCP-2)":[4],"increases":[5],"in":[6,10,58,79,90],"streptozotocin-induced":[7],"diabetes,":[8],"resulting":[9,57],"mitochondria":[11],"uncoupling,":[12],"i.e.,":[13],"increased":[14,49],"oxygen":[15,55,60],"consumption":[16],"unrelated":[17],"to":[18,25,42],"active":[19],"transport.":[20],"The":[21,97],"present":[22],"study":[23],"aimed":[24],"investigate":[26],"the":[27,100,117],"role":[28],"of":[29,95,102,104],"UCP-2":[30,68,76,106],"for":[31,99],"normal":[32],"and":[33,53,62,73,81],"diabetic":[34,82],"kidney":[35,54],"function":[36,86],"utilizing":[37],"small":[38],"interference":[39],"RNA":[40],"(siRNA)":[41],"reduce":[43],"expression.":[45],"Diabetic":[46],"animals":[47,83],"had":[48],"glomerular":[50],"filtration":[51],"rate":[52],"consumption,":[56],"decreased":[59,71],"tension":[61],"transported":[63],"sodium":[64],"per":[65],"consumed":[66],"oxygen.":[67],"levels":[70],"50%":[74],"after":[75],"siRNA":[77],"administration":[78],"control":[80],"respectively.":[84],"was":[87],"unaffected":[88],"by":[89,116],"vivo":[91],"siRNA-mediated":[92],"gene":[93],"silencing":[94],"UCP-2.":[96],"reason":[98],"lack":[101],"effect":[103],"reducing":[105],"is":[107],"presently":[108],"unknown":[109],"but":[110],"may":[111],"involve":[112],"compensatory":[113],"mitochondrial":[114],"adenosine":[118],"nucleotide":[119],"transporter.":[120]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
