{"id":"https://openalex.org/W59585391","doi":null,"title":"Progesterone induces BRCA1 mRNA decrease, cell cycle alterations and apoptosis in the MCF7 breast cancer cell line.","display_name":"Progesterone induces BRCA1 mRNA decrease, cell cycle alterations and apoptosis in the MCF7 breast cancer cell line.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W59585391","mag":"59585391","pmid":"https://pubmed.ncbi.nlm.nih.gov/15816544"},"language":"en","primary_location":{"id":"pmid:15816544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15816544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113568169","display_name":"Y. Ansquer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yan Ansquer","raw_affiliation_strings":["INSERM U 481, Facult\u00e9 de M\u00e9decine Xavier Bichat, 75018 Paris, France. yan.ansquer@lmr.ap-hop-paris.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U 481, Facult\u00e9 de M\u00e9decine Xavier Bichat, 75018 Paris, France. yan.ansquer@lmr.ap-hop-paris.fr","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051676842","display_name":"Agn\u00e8s Legrand","orcid":"https://orcid.org/0000-0002-1063-2816","observed_orcids":["https://orcid.org/0000-0002-1063-2816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agn\u00e8s Legrand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111433848","display_name":"A.F. Bringuier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annie-France Bringuier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020074171","display_name":"Nathalie Vadrot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathalie Vadrot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032351923","display_name":"Bernard R. Lardeux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Lardeux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036742391","display_name":"Laurent Mandelbrot","orcid":"https://orcid.org/0000-0002-5883-7597","observed_orcids":["https://orcid.org/0000-0002-5883-7597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurent Mandelbrot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113512612","display_name":"G\u00e9rard Feldmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G\u00e9rard Feldmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1534,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7523889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"25","issue":"1A","first_page":"243","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9869999885559082},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.968999981880188},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cyclin-a","display_name":"cyclin A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hormone-dependent-cancers","display_name":"hormone-dependent tumors","score":0.7059999704360962},{"id":"https://openalex.org/keywords/hereditary-breast-and-ovarian-cancer-syndrome","display_name":"hereditary breast and ovarian cancer","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6985939741134644},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6447268128395081},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5671990513801575},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5654829144477844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4852123558521271},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4730971157550812},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4650847315788269},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44997626543045044},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4366469085216522},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4300454258918762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42907774448394775},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.41101136803627014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.287078320980072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06013154983520508}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15816544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15816544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:59585391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15816544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1489499258","https://openalex.org/W1811094195","https://openalex.org/W1873998261","https://openalex.org/W1977779461","https://openalex.org/W1982457346","https://openalex.org/W1993446755","https://openalex.org/W1994066190","https://openalex.org/W1996635873","https://openalex.org/W2000564958","https://openalex.org/W2003099225","https://openalex.org/W2012945894","https://openalex.org/W2031987334","https://openalex.org/W2036546668","https://openalex.org/W2048721919","https://openalex.org/W2073255752","https://openalex.org/W2079214433","https://openalex.org/W2079525757","https://openalex.org/W2080336441","https://openalex.org/W2082411289","https://openalex.org/W2083304880","https://openalex.org/W2106538596","https://openalex.org/W2134669147","https://openalex.org/W2160016715","https://openalex.org/W2401522950","https://openalex.org/W2403429472","https://openalex.org/W2515721699","https://openalex.org/W2772971838"],"related_works":["https://openalex.org/W2134669147","https://openalex.org/W2946490849","https://openalex.org/W2059896917","https://openalex.org/W2896351813","https://openalex.org/W2153864725","https://openalex.org/W7099390844","https://openalex.org/W2055071546","https://openalex.org/W7043390913","https://openalex.org/W2560982043","https://openalex.org/W2944506941"],"abstract_inverted_index":{"BACKGROUND:":[0],"Inherited":[1],"mutations":[2],"of":[3,20,23,101,117,132,141],"the":[4,44,142],"BRCA1":[5,24,38,70,92,118],"gene":[6],"are":[7],"responsible":[8],"for":[9,65],"hereditary":[10],"breast":[11,46,54],"and":[12,73,87,93],"ovarian":[13],"cancer":[14,28,47,55],"syndrome.":[15],"However,":[16],"little":[17],"is":[18],"known":[19],"how":[21],"disruption":[22],"functions":[25],"preferentially":[26],"increases":[27],"risk":[29],"in":[30,43,106,119],"hormone-dependent":[31],"organs.":[32],"We":[33],"aimed":[34],"to":[35,128],"study":[36],"whether":[37],"was":[39],"regulated":[40],"by":[41],"progesterone":[42,64,80,126],"MCF7":[45,53,107,120],"cell":[48,82,84,133],"line.":[49],"MATERIALS":[50],"AND":[51],"METHODS:":[52],"cells":[56,108,121],"were":[57,75,104],"incubated":[58,109,122],"with":[59,110,123],"10(-4)":[60,78,124],"or":[61,67],"10(-10)":[62,111],"M":[63,79,112,125],"24":[66],"48":[68],"hours.":[69],"expression,":[71],"proliferation":[72],"apoptosis":[74],"analysed.":[76],"RESULTS:":[77],"decreased":[81],"proliferation,":[83],"cycle":[85,134],"progression":[86],"induced":[88],"apoptosis.":[89],"In":[90,98],"addition,":[91],"cyclin":[94],"A":[95],"mRNA":[96],"decreased.":[97],"contrast,":[99],"none":[100],"these":[102],"effects":[103],"observed":[105],"progesterone.":[113],"CONCLUSION:":[114],"The":[115],"down-regulation":[116],"seems":[127],"be":[129],"a":[130,138],"consequence":[131],"alterations":[135],"rather":[136],"than":[137],"direct":[139],"effect":[140],"hormone":[143],"on":[144],"BRCA1.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
