{"id":"https://openalex.org/W59496444","doi":null,"title":"An in silico analysis of the glutamate dehydrogenases of Teladorsagia circumcincta and Haemonchus contortus","display_name":"An in silico analysis of the glutamate dehydrogenases of Teladorsagia circumcincta and Haemonchus contortus","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W59496444","mag":"59496444"},"language":"en","primary_location":{"id":"pmh:oai:researchonline.jcu.edu.au:35819","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.jcu.edu.au/35819/1/In%20silico%20GDH.pdf","pdf_url":"https://researchonline.jcu.edu.au/35819/1/In%20silico%20GDH.pdf","source":{"id":"https://openalex.org/S4306400519","display_name":"ResearchOnline at James Cook University (James Cook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86467917","host_organization_name":"James Cook University","host_organization_lineage":["https://openalex.org/I86467917"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/72f746c177ba496c8ae966a66414a0a3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103465126","display_name":"Simon B Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"SIMON BROWN","raw_affiliation_strings":["Deviot Institute, Deviot,  Tasmania 7275, Australia.   School of Human Life Sciences,  University of Tasmania, Locked Bag 1320,  Launceston, Tasmania 7250, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deviot Institute, Deviot,  Tasmania 7275, Australia.   School of Human Life Sciences,  University of Tasmania, Locked Bag 1320,  Launceston, Tasmania 7250, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016506861","display_name":"Noorzaid Muhamad","orcid":"https://orcid.org/0000-0002-7459-0088","observed_orcids":["https://orcid.org/0000-0002-7459-0088"]},"institutions":[{"id":"https://openalex.org/I4528857","display_name":"University of Kuala Lumpur","ror":"https://ror.org/026wwrx19","country_code":"MY","type":"education","lineage":["https://openalex.org/I4528857"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"NOORZAID MUHAMAD","raw_affiliation_strings":["University Kuala Lumpur, Royal College  of Medicine Perak, 3 Greentown Road,  30450 Ipoh, Perak, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Kuala Lumpur, Royal College  of Medicine Perak, 3 Greentown Road,  30450 Ipoh, Perak, Malaysia","institution_ids":["https://openalex.org/I4528857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062944538","display_name":"L.R. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51158804","display_name":"Massey University","ror":"https://ror.org/052czxv31","country_code":"NZ","type":"education","lineage":["https://openalex.org/I51158804"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"LISA R. WALKER","raw_affiliation_strings":["Institute of Food, Nutrition and Human  Health, Massey University, Private Bag  11222, Palmerston North, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food, Nutrition and Human  Health, Massey University, Private Bag  11222, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I51158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112582620","display_name":"Kevin C. Pedley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51158804","display_name":"Massey University","ror":"https://ror.org/052czxv31","country_code":"NZ","type":"education","lineage":["https://openalex.org/I51158804"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"KEVIN C. PEDLEY","raw_affiliation_strings":["Institute of Food, Nutrition and Human  Health, Massey University, Private Bag  11222, Palmerston North, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food, Nutrition and Human  Health, Massey University, Private Bag  11222, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I51158804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109912555","display_name":"David C. Simcock","orcid":"https://orcid.org/0000-0001-8959-9889","observed_orcids":["https://orcid.org/0000-0001-8959-9889"]},"institutions":[{"id":"https://openalex.org/I51158804","display_name":"Massey University","ror":"https://ror.org/052czxv31","country_code":"NZ","type":"education","lineage":["https://openalex.org/I51158804"]},{"id":"https://openalex.org/I86467917","display_name":"James Cook University","ror":"https://ror.org/04gsp2c11","country_code":"AU","type":"education","lineage":["https://openalex.org/I86467917"]}],"countries":["AU","NZ"],"is_corresponding":false,"raw_author_name":"DAVID C. SIMCOCK","raw_affiliation_strings":["Deviot Institute, Deviot,  Tasmania 7275, Australia.   Institute of Food, Nutrition and Human  Health, Massey University, Private Bag  11222, Palmerston North, New Zealand. Faculty of Medicine, Health and  Molecular Sciences, James Cook  University, Cairns, Queensland 4870,  Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deviot Institute, Deviot,  Tasmania 7275, Australia.   Institute of Food, Nutrition and Human  Health, Massey University, Private Bag  11222, Palmerston North, New Zealand. Faculty of Medicine, Health and  Molecular Sciences, James Cook  University, Cairns, Queensland 4870,  Australia","institution_ids":["https://openalex.org/I51158804","https://openalex.org/I86467917"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00210054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-dehydrogenase","display_name":"glutamate dehydrogenase","score":1.0},{"id":"https://openalex.org/keywords/teladorsagia-circumcincta","display_name":"Teladorsagia circumcincta","score":1.0},{"id":"https://openalex.org/keywords/haemonchus-contortus","display_name":"Haemonchus contortus","score":1.0},{"id":"https://openalex.org/keywords/enzyme-structure-modeling","display_name":"enzyme structure modeling","score":0.4690000116825104},{"id":"https://openalex.org/keywords/sequence-conservation","display_name":"sequence conservation","score":0.5740000009536743},{"id":"https://openalex.org/keywords/ligand-binding-site","display_name":"ligand binding sites","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tryptophan-substitution","display_name":"tryptophan substitution","score":0.8740000128746033},{"id":"https://openalex.org/keywords/anthelmintic-drug-targets","display_name":"anthelmintic drug targets","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2776595779","wikidata":"https://www.wikidata.org/wiki/Q7695599","display_name":"Teladorsagia circumcincta","level":4,"score":0.9177384972572327},{"id":"https://openalex.org/C2779825395","wikidata":"https://www.wikidata.org/wiki/Q1754336","display_name":"Haemonchus contortus","level":3,"score":0.7472100853919983},{"id":"https://openalex.org/C2777202666","wikidata":"https://www.wikidata.org/wiki/Q417383","display_name":"Glutamate dehydrogenase","level":4,"score":0.5926750898361206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.535565972328186},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.5153729319572449},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5104848146438599},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4697193205356598},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4632856249809265},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.43823644518852234},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4297637939453125},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.42777135968208313},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36796802282333374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2847525477409363},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.24392762780189514},{"id":"https://openalex.org/C2778830712","wikidata":"https://www.wikidata.org/wiki/Q5185","display_name":"Nematode","level":2,"score":0.15559813380241394},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07925990223884583},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:researchonline.jcu.edu.au:35819","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.jcu.edu.au/35819/1/In%20silico%20GDH.pdf","pdf_url":"https://researchonline.jcu.edu.au/35819/1/In%20silico%20GDH.pdf","source":{"id":"https://openalex.org/S4306400519","display_name":"ResearchOnline at James Cook University (James Cook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86467917","host_organization_name":"James Cook University","host_organization_lineage":["https://openalex.org/I86467917"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:72f746c177ba496c8ae966a66414a0a3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/72f746c177ba496c8ae966a66414a0a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of BioScience and Biotechnology, Vol 3, Iss 1, Pp 49-60 (2014)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:72f746c177ba496c8ae966a66414a0a3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/72f746c177ba496c8ae966a66414a0a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of BioScience and Biotechnology, Vol 3, Iss 1, Pp 49-60 (2014)","raw_type":"article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W142391650","https://openalex.org/W187013985","https://openalex.org/W1497712500","https://openalex.org/W1519727504","https://openalex.org/W1543932334","https://openalex.org/W1981509964","https://openalex.org/W1982447955","https://openalex.org/W1982611963","https://openalex.org/W1987430808","https://openalex.org/W2004324768","https://openalex.org/W2007144056","https://openalex.org/W2010249729","https://openalex.org/W2012072946","https://openalex.org/W2017519756","https://openalex.org/W2018014586","https://openalex.org/W2028297170","https://openalex.org/W2030966943","https://openalex.org/W2054698000","https://openalex.org/W2059338233","https://openalex.org/W2060259273","https://openalex.org/W2068301872","https://openalex.org/W2083851878","https://openalex.org/W2084480094","https://openalex.org/W2085263375","https://openalex.org/W2085423194","https://openalex.org/W2085803143","https://openalex.org/W2097382368","https://openalex.org/W2098770192","https://openalex.org/W2103967715","https://openalex.org/W2106151976","https://openalex.org/W2118200955","https://openalex.org/W2132632499","https://openalex.org/W2134294998","https://openalex.org/W2141856080","https://openalex.org/W2145709194","https://openalex.org/W2154320306","https://openalex.org/W2155434795","https://openalex.org/W2158811282","https://openalex.org/W2170672962","https://openalex.org/W2277339801","https://openalex.org/W2337240748"],"related_works":["https://openalex.org/W2088552515","https://openalex.org/W2010249729","https://openalex.org/W2158811282","https://openalex.org/W1566161480","https://openalex.org/W1580736768","https://openalex.org/W2034984803","https://openalex.org/W3033930475","https://openalex.org/W2087789912","https://openalex.org/W1991640055","https://openalex.org/W2087459352"],"abstract_inverted_index":{"Nematode":[0],"glutamate":[1],"dehydrogenase":[2],"(GDH)":[3],"amino":[4],"acid":[5],"sequences":[6,203],"are":[7,14,36,172],"very":[8,16,91,107,140],"highly":[9,45],"conserved":[10,38,46],"(68-99%":[11],"identity)":[12],"and":[13,23,39,61,74,100,123,130,153,170,193,200,218],"also":[15],"similar":[17,92],"to":[18,41,93,179],"those":[19],"of":[20,48,67,70,82,95,103,111,132,147,156,163,181,191,210,221,236],"the":[21,49,53,57,68,71,83,96,101,104,112,117,121,127,133,157,161,164,182,189,197,211,215,219,229,233,237],"bovine":[22,97,113,122,158,183],"human":[24],"enzymes":[25,166],"(54-60%":[26],"identity).":[27],"The":[28,80,142,176,207],"residues":[29,134],"involved":[30,135,186],"in":[31,44,136,187,196],"binding":[32,138,188],"nucleotides":[33],"or":[34],"substrates":[35],"completely":[37],"tend":[40],"be":[42],"located":[43],"regions":[47],"sequence.":[50],"Based":[51],"on":[52],"strong":[54],"homology":[55],"between":[56,120],"bovine,":[58],"Teladorsagia":[59],"circumcincta":[60,73,85,125,149,199,239],"Haemonchus":[62],"contortus":[63,76,202],"GDH":[64],"sequences,":[65],"models":[66],"structure":[69,81],"T.":[72,84,124,148,198,238],"H.":[75,201],"monomers":[77],"were":[78,139],"constructed.":[79],"monomer":[86,99],"obtained":[87],"using":[88],"SWISS-MODEL":[89],"was":[90],"that":[94,110,155],"enzyme":[98,114,184],"backbone":[102],"polypetide":[105],"deviated":[106],"little":[108],"from":[109],"monomer.":[115],"Despite":[116],"sequence":[118],"differences":[119],"enzymes,":[126],"relative":[128],"positions":[129],"orientations":[131],"ligand":[137],"similar.":[141,175],"reported":[143],"Km":[144],"for":[145,167,240],"NADP+":[146,192],"is":[150,185,194],"about":[151],"35":[152],"times":[154],"enzyme,":[159],"whereas":[160],"Kms":[162],"two":[165],"glutamate,":[168],"\u03b1-ketoglutarate":[169],"NAD(P)H":[171],"much":[173],"more":[174],"residue":[177],"corresponding":[178],"S267":[180],"2'-phosphate":[190],"replaced":[195],"by":[204,214,228],"a":[205],"tryptophan.":[206],"partial":[208],"occlusion":[209],"NAD(P)-binding":[212],"site":[213],"tryptophan":[216],"sidechain":[217],"loss":[220],"at":[222],"least":[223],"one":[224],"potential":[225],"H-bond":[226],"provided":[227],"serine":[230],"may":[231],"explain":[232],"lower":[234],"affinity":[235],"NADP+.":[241]},"counts_by_year":[{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
