{"id":"https://openalex.org/W59475270","doi":null,"title":"Serotonergic modulation of Neural activities in the entorhinal cortex.","display_name":"Serotonergic modulation of Neural activities in the entorhinal cortex.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W59475270","mag":"59475270","pmid":"https://pubmed.ncbi.nlm.nih.gov/23320133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3544218"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3544218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3544218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Physiol Pathophysiol Pharmacol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3544218","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081093925","display_name":"Saobo Lei","orcid":"https://orcid.org/0000-0003-3667-8270","observed_orcids":["https://orcid.org/0000-0003-3667-8270","https://orcid.org/0000-0002-3882-0253"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saobo Lei","raw_affiliation_strings":["Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota Grand Forks, ND58203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota Grand Forks, ND58203, USA","institution_ids":["https://openalex.org/I24571045"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081093925"],"corresponding_institution_ids":["https://openalex.org/I24571045"],"apc_list":null,"apc_paid":null,"fwci":0.4316,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.51718446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"4","first_page":"201","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.15760000050067902,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.149399995803833,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.9160000085830688},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/serotonergic-modulation","display_name":"serotonergic modulation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.8420000076293945},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/5-ht6-receptor","display_name":"5-HT6 receptor","score":0.8740000128746033},{"id":"https://openalex.org/keywords/5-ht1d-receptor","display_name":"5-HT1D receptor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/5-ht1e-receptor","display_name":"5-HT1E receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/raphe-nuclei","display_name":"raphe nuclei","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6110000014305115},{"id":"https://openalex.org/keywords/synaptic-inhibition","display_name":"synaptic inhibition","score":0.6520000100135803},{"id":"https://openalex.org/keywords/gaba-release","display_name":"GABA release","score":0.9670000076293945},{"id":"https://openalex.org/keywords/acetylcholine-release","display_name":"acetylcholine release","score":0.9390000104904175},{"id":"https://openalex.org/keywords/epileptiform-activity","display_name":"epileptiform activity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8920000195503235},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/neural-circuits","display_name":"neural circuits","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.9361729025840759},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7343474626541138},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6790600419044495},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.6028052568435669},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.5824263095855713},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.4934023916721344},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4489641487598419},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.4374418556690216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38755202293395996},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3641276955604553},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3543294370174408},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3488270938396454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25679558515548706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23889285326004028},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16645896434783936}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3544218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3544218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Physiol Pathophysiol Pharmacol","raw_type":"Text"},{"id":"pmid:23320133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23320133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of physiology, pathophysiology and pharmacology","raw_type":"Journal Article"},{"id":"mag:2556397485","doi":null,"is_oa":false,"landing_page_url":"http://www.ijppp.org/files/ijppp1211003.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:59475270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23320133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3544218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3544218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Physiol Pathophysiol Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3227296888","display_name":"Roles and mechanisms of neurotensin in learning and memory","funder_award_id":"R01MH082881","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W1574592181","https://openalex.org/W1965688590","https://openalex.org/W1969855549","https://openalex.org/W1972646266","https://openalex.org/W1975275629","https://openalex.org/W1975701706","https://openalex.org/W1976363912","https://openalex.org/W1980796284","https://openalex.org/W1984480623","https://openalex.org/W1985437286","https://openalex.org/W1988687093","https://openalex.org/W1991974510","https://openalex.org/W1993940897","https://openalex.org/W1994356583","https://openalex.org/W1996345484","https://openalex.org/W1998811784","https://openalex.org/W1999330418","https://openalex.org/W2001344969","https://openalex.org/W2001486260","https://openalex.org/W2002582636","https://openalex.org/W2005886801","https://openalex.org/W2008291612","https://openalex.org/W2009332732","https://openalex.org/W2009821818","https://openalex.org/W2010175951","https://openalex.org/W2010918702","https://openalex.org/W2014654911","https://openalex.org/W2016983964","https://openalex.org/W2018947767","https://openalex.org/W2019103724","https://openalex.org/W2022527552","https://openalex.org/W2026478831","https://openalex.org/W2027520560","https://openalex.org/W2027579198","https://openalex.org/W2028223342","https://openalex.org/W2029084216","https://openalex.org/W2039141992","https://openalex.org/W2040051708","https://openalex.org/W2045290451","https://openalex.org/W2045947992","https://openalex.org/W2047318106","https://openalex.org/W2057470835","https://openalex.org/W2057679038","https://openalex.org/W2058369478","https://openalex.org/W2059961390","https://openalex.org/W2060502492","https://openalex.org/W2061114211","https://openalex.org/W2061697038","https://openalex.org/W2063281437","https://openalex.org/W2067917778","https://openalex.org/W2069304323","https://openalex.org/W2069559360","https://openalex.org/W2071248144","https://openalex.org/W2075331040","https://openalex.org/W2075657688","https://openalex.org/W2076063967","https://openalex.org/W2077198645","https://openalex.org/W2078795039","https://openalex.org/W2080589549","https://openalex.org/W2081331575","https://openalex.org/W2081355012","https://openalex.org/W2085259372","https://openalex.org/W2094201117","https://openalex.org/W2099225954","https://openalex.org/W2105606484","https://openalex.org/W2119156559","https://openalex.org/W2126974689","https://openalex.org/W2127019545","https://openalex.org/W2129789527","https://openalex.org/W2137435206","https://openalex.org/W2139836368","https://openalex.org/W2141202598","https://openalex.org/W2153853866","https://openalex.org/W2158056477","https://openalex.org/W2161034595","https://openalex.org/W2166105988","https://openalex.org/W2192222004","https://openalex.org/W2416298955"],"related_works":["https://openalex.org/W2556397485","https://openalex.org/W2061955472","https://openalex.org/W2022527552","https://openalex.org/W2099225954","https://openalex.org/W2192222004","https://openalex.org/W2166105988","https://openalex.org/W2005886801","https://openalex.org/W2060502492","https://openalex.org/W2078795039","https://openalex.org/W1875362086"],"abstract_inverted_index":{"The":[0,21,63,91],"entorhinal":[1,127],"cortex":[2],"(EC)":[3],"is":[4,23,48,110,205],"considered":[5],"as":[6,30],"the":[7,11,19,70,74,98,105,123,131,175,178,183,197,203,216,225],"gate":[8],"to":[9],"control":[10],"flow":[12],"of":[13,18,60,80,101,137,146,159,171,180,199,206,218],"information":[14],"into":[15],"and":[16,34,36,43,58,76,89,97,129,151,193],"out":[17],"hippocampus.":[20],"EC":[22,64,106,184,204],"important":[24],"for":[25,156],"numerous":[26],"physiological":[27,56],"functions":[28,57,179],"such":[29],"emotional":[31],"control,":[32],"learning":[33],"memory":[35],"pathological":[37],"disorders":[38],"including":[39,83],"Alzheimer's":[40,191],"disease,":[41,190],"schizophrenia":[42],"temporal":[44],"lobe":[45],"epilepsy.":[46],"Serotonin":[47,118,125],"a":[49,111],"classical":[50],"neurotransmitter":[51],"which":[52],"may":[53,165,185],"modify":[54],"these":[55],"pathology":[59],"neurological":[61],"diseases.":[62],"receives":[65],"profuse":[66],"serotonergic":[67,81,95,102,200],"innervations":[68],"from":[69],"raphe":[71],"nuclei":[72],"in":[73,104,114,122,168,174,182,188,202,224],"brainstem":[75],"expresses":[77],"high":[78],"density":[79],"receptors":[82,103,139,153,164],"5-HT(1A),":[84],"5-HT(1D),":[85],"5-HT(1E),":[86],"5-HT(2A),":[87],"5-HT(3)":[88,163],"5-HT(6).":[90],"prominent":[92],"innervation":[93],"by":[94],"neurons":[96,128],"dense":[99],"expression":[100],"suggest":[107],"that":[108],"serotonin":[109,181,219],"major":[112,207],"modulator":[113],"this":[115],"brain":[116],"region.":[117],"exerts":[119],"inhibitory":[120],"effects":[121,217],"EC.":[124,176,226],"hyperpolarizes":[126],"inhibits":[130],"excitatory":[132],"synaptic":[133],"transmission":[134],"via":[135,144],"activation":[136,145],"5-HT(1A)":[138,150],"but":[140],"facilitates":[141],"GABA":[142],"release":[143,173],"5-HT(2A)":[147,152],"receptors.":[148],"Both":[149],"are":[154],"required":[155],"serotonin-induced":[157],"inhibition":[158,170],"epileptiform":[160],"activity":[161,223],"although":[162],"be":[166,186],"involved":[167],"serotonin-mediated":[169],"acetylcholine":[172],"Furthermore,":[177],"implicated":[187],"Parkinson's":[189],"disease":[192],"depression.":[194],"Thus,":[195],"understanding":[196],"roles":[198],"modulation":[201],"clinical":[208],"importance.":[209],"Here,":[210],"I":[211],"review":[212],"recent":[213],"findings":[214],"concerning":[215],"on":[220],"neural":[221],"circuitry":[222]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
