{"id":"https://openalex.org/W5941526","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.710.12","title":"Role of MAPK/AP\u20101 Signaling in the protection of 2\u2010choloroethyl ethyl sulfide (CEES) \u2010 induced lung injury by antioxidant liposome","display_name":"Role of MAPK/AP\u20101 Signaling in the protection of 2\u2010choloroethyl ethyl sulfide (CEES) \u2010 induced lung injury by antioxidant liposome","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W5941526","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.710.12","mag":"5941526"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.710.12","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.710.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.710.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102128752","display_name":"Sutapa Mukhopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sutapa Mukhopadhyay","raw_affiliation_strings":["Cancer Biology Meharry Medical College Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Meharry Medical College Nashville TN","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112520459","display_name":"Shyamali Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyamali Mukherjee","raw_affiliation_strings":["Cancer Biology Meharry Medical College Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Meharry Medical College Nashville TN","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082565452","display_name":"Milton G. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milton Smith","raw_affiliation_strings":["Amaox, Ltd Melbourne FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amaox, Ltd Melbourne FL","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103404831","display_name":"Salil K. Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salil K Das","raw_affiliation_strings":["Cancer Biology Meharry Medical College Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Meharry Medical College Nashville TN","institution_ids":["https://openalex.org/I118073183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00065779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.32280001044273376,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.32280001044273376,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":0.1080000028014183,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mapk-ap-1-signaling","display_name":"MAPK/AP-1 signaling","score":0.8479999899864197},{"id":"https://openalex.org/keywords/2-chloroethyl-ethyl-sulfide","display_name":"2-chloroethyl ethyl sulfide","score":0.9229999780654907},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9290000200271606},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.781000018119812},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8500000238418579},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5590000152587891},{"id":"https://openalex.org/keywords/antidotes","display_name":"antidotes","score":0.6349999904632568},{"id":"https://openalex.org/keywords/chemical-lung-injury","display_name":"chemical lung injury","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.798583447933197},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7389684319496155},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6364396214485168},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5700010657310486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5608124732971191},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.44561389088630676},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.36480098962783813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34798792004585266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3313255310058594}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.710.12","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.710.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.710.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1975330391","https://openalex.org/W2073716990","https://openalex.org/W2008631464","https://openalex.org/W2559131604","https://openalex.org/W3016261568","https://openalex.org/W2015153552","https://openalex.org/W2069057903","https://openalex.org/W1990238477","https://openalex.org/W2069284067","https://openalex.org/W2045741487"],"abstract_inverted_index":{"We":[0],"reported":[1],"earlier":[2],"that":[3,143],"antioxidant":[4,42,57,122],"liposomes":[5,43],"containing":[6],"N\u2010acetyl":[7],"cysteine":[8],"(NAC)":[9],"and":[10,139],"vitamin":[11,148],"E":[12,149],"protect":[13],"against":[14,160],"CEES\u2010induced":[15,89],"lung":[16,29,39,161],"injury.":[17,30,162],"Our":[18],"previous":[19],"studies":[20],"also":[21],"indicated":[22],"a":[23,47,85,126,151],"role":[24],"of":[25,38,49,55,88,91,101,104,110,132],"MAPK/AP\u20101":[26],"signaling":[27],"in":[28,98,128,145],"The":[31,69,82],"present":[32],"study":[33],"examines":[34],"whether":[35],"the":[36,56,99,105,108,117,121,129],"protection":[37],"injury":[40],"by":[41,46,116,164],"is":[44],"mediated":[45],"control":[48],"MAPKs/AP\u20101":[50],"signaling.":[51],"A":[52],"single":[53],"dose":[54],"liposome":[58,123,152],"(200":[59],"\u03bcl)":[60],"was":[61,96,114],"administered":[62],"intratracheally":[63],"5":[64],"min":[65],"after":[66,79],"CEES":[67,80],"exposure.":[68,81],"animals":[70],"were":[71],"sacrificed":[72],"either":[73],"1":[74],"h":[75],"or":[76],"30":[77],"days":[78],"treatment":[83,124],"caused":[84,125],"down":[86],"regulation":[87],"activation":[90,100,109],"TNF\u2010\u03b1.":[92],"Although,":[93],"no":[94],"change":[95],"observed":[97],"any":[102],"member":[103],"MAPKs":[106],"family,":[107],"AP\u20101":[111],"transcription":[112],"factors":[113],"down\u2010regulated":[115],"treatment.":[118],"In":[119],"addition,":[120],"decrease":[127],"protein":[130],"levels":[131],"two":[133],"cell":[134],"cycle":[135],"proteins,":[136],"cyclin":[137],"D1":[138],"PCNA.":[140],"This":[141],"suggests":[142],"NAC":[144],"combination":[146],"with":[147],"as":[150,156],"can":[153],"be":[154],"used":[155],"an":[157],"effective":[158],"antidote":[159],"(Supported":[163],"US":[165],"Army":[166],"Grant":[167],"W81XWH\u201006\u20102\u20100044)":[168]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
