{"id":"https://openalex.org/W5938990","doi":null,"title":"Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review.","display_name":"Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W5938990","mag":"5938990","pmid":"https://pubmed.ncbi.nlm.nih.gov/22834392"},"language":"en","primary_location":{"id":"pmid:22834392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22834392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of oral implantology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067775878","display_name":"Marco AB Esposito","orcid":"https://orcid.org/0009-0004-2952-9933","observed_orcids":["https://orcid.org/0009-0004-2952-9933","https://orcid.org/0000-0003-4543-8818"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marco Esposito","raw_affiliation_strings":["Department of Biomaterials, The Sahlgrenska Academy at G\u00f6teborg University, Sweden. espositomarco@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomaterials, The Sahlgrenska Academy at G\u00f6teborg University, Sweden. espositomarco@hotmail.com","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014331094","display_name":"Maria Gabriella Grusovin","orcid":"https://orcid.org/0000-0003-4078-384X","observed_orcids":["https://orcid.org/0000-0003-4078-384X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Gabriella Grusovin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040576917","display_name":"Helen V Worthington","orcid":"https://orcid.org/0000-0002-4851-7469","observed_orcids":["https://orcid.org/0000-0002-4851-7469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen V Worthington","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.3718,"has_fulltext":false,"cited_by_count":175,"citation_normalized_percentile":{"value":0.99405145,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"5 Suppl","issue":null,"first_page":"S21","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peri-implantitis","display_name":"peri-implantitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dental-implants","display_name":"dental implants","score":0.8149999976158142},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.7319999933242798},{"id":"https://openalex.org/keywords/peri-implant-disease-treatment","display_name":"peri-implant disease treatment","score":0.7149999737739563},{"id":"https://openalex.org/keywords/bio-oss","display_name":"Bio-Oss","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nanocrystalline-hydroxyapatite","display_name":"nanocrystalline hydroxyapatite","score":0.9950000047683716},{"id":"https://openalex.org/keywords/peri-implant-bone-loss","display_name":"peri-implant bone loss","score":0.6959999799728394},{"id":"https://openalex.org/keywords/probing-attachment-level","display_name":"probing attachment level","score":0.7020000219345093},{"id":"https://openalex.org/keywords/probing-depth","display_name":"probing depth","score":0.8339999914169312},{"id":"https://openalex.org/keywords/implant-failure","display_name":"implant failure","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9318802356719971},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.7384737133979797},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.6414684057235718},{"id":"https://openalex.org/C2780802913","wikidata":"https://www.wikidata.org/wiki/Q601168","display_name":"Peri-implantitis","level":3,"score":0.5864976644515991},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.47049617767333984},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.44105294346809387},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4388265311717987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15347334742546082},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1377372145652771},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09702825546264648},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015921","descriptor_name":"Dental Implants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016301","descriptor_name":"Alveolar Bone Loss","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D016348","descriptor_name":"Osseointegration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019232","descriptor_name":"Dental Restoration Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057747","descriptor_name":"Periodontal Debridement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057873","descriptor_name":"Peri-Implantitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:22834392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22834392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of oral implantology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/99e91b6b-4373-4bdc-bb0f-3caa313ee7dd","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/99e91b6b-4373-4bdc-bb0f-3caa313ee7dd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Esposito, M, Grusovin, M G & Worthington, H V 2012, 'Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review.', European Journal of Oral Implantology, vol. 5, pp. S21-41.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:5938990","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Helen_Worthington/publication/230571480_Treatment_of_peri-implantitis_what_interventions_are_effective_A_Cochrane_systematic_review/links/00b7d5295c10e998eb000000.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2484351632","display_name":"European journal of oral implantology","issn_l":"1756-2406","issn":["1756-2406"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European journal of oral implantology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W35603954","https://openalex.org/W197324099","https://openalex.org/W234459449","https://openalex.org/W615186145","https://openalex.org/W1481346777","https://openalex.org/W1492422513","https://openalex.org/W1581103454","https://openalex.org/W1603233133","https://openalex.org/W1733418913","https://openalex.org/W1912843579","https://openalex.org/W1947685769","https://openalex.org/W1962363690","https://openalex.org/W2000811260","https://openalex.org/W2003872568","https://openalex.org/W2023006363","https://openalex.org/W2027139718","https://openalex.org/W2030332034","https://openalex.org/W2033451677","https://openalex.org/W2036123034","https://openalex.org/W2042573744","https://openalex.org/W2058846290","https://openalex.org/W2059564075","https://openalex.org/W2066050102","https://openalex.org/W2067384953","https://openalex.org/W2071564049","https://openalex.org/W2079717654","https://openalex.org/W2089892355","https://openalex.org/W2099814449","https://openalex.org/W2106258769","https://openalex.org/W2110886828","https://openalex.org/W2116593393","https://openalex.org/W2119091515","https://openalex.org/W2122291465","https://openalex.org/W2123012614","https://openalex.org/W2130235475","https://openalex.org/W2133475573","https://openalex.org/W2134326990","https://openalex.org/W2148598284","https://openalex.org/W2412069691","https://openalex.org/W2989772492","https://openalex.org/W3203425278"],"related_works":["https://openalex.org/W343603661","https://openalex.org/W2091395224","https://openalex.org/W2122291465","https://openalex.org/W4256284519","https://openalex.org/W2075123878","https://openalex.org/W2321319661","https://openalex.org/W2795239242","https://openalex.org/W4394859907","https://openalex.org/W1993974047","https://openalex.org/W3049210567"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"identify":[2],"the":[3,32,77,81,100,104,107,110,113,159,245,332,362,444,454,479,485],"most":[4,333],"effective":[5,334],"interventions":[6,45,155,165,172,178,186,335,347],"for":[7,37,46,129,135,300,336,482],"treating":[8,47,337],"peri-implantitis":[9,48,473],"around":[10,49,247],"osseointe-grated":[11],"oral":[12,50],"implants.":[13,51],"MATERIALS":[14],"AND":[15],"METHODS:":[16],"The":[17,96,153],"Cochrane":[18],"Oral":[19],"Health":[20],"Group's":[21],"Trials":[22],"Register,":[23],"CENTRAL,":[24],"MEDLINE":[25],"and":[26,64,67,83,90,102,132,175,181,264,291,307,383,413,447],"EMBASE":[27],"were":[28,55,86,121,147,151,156,211,419,450],"searched":[29],"up":[30,475],"to":[31,170,184,194,201,219,234,262,276,305,312,315,342,369,428,476],"9th":[33],"of":[34,69,72,76,80,109,206,226,244,256,270,297,358,364,395,404,415,460,472,478,484],"June":[35],"2011":[36],"randomised":[38],"controlled":[39],"trials":[40,82,146,217,442],"(RCTs)":[41],"comparing":[42],"agents":[43],"or":[44,223],"Primary":[52],"outcome":[53],"measures":[54],"implant":[56,105],"failure,":[57],"radiographic":[58],"marginal":[59],"bone":[60,246],"level":[61],"change,":[62],"complications":[63],"side":[65],"effects,":[66],"recurrence":[68,471],"peri-implantitis.":[70,338,396],"Screening":[71],"eligible":[73,145],"studies,":[74],"assessment":[75],"methodological":[78],"quality":[79],"data":[84],"extraction":[85],"conducted":[87],"in":[88,158,213,237,367,381,389,432,474],"duplicate":[89],"independently":[91],"by":[92,392],"two":[93,214],"review":[94],"authors.":[95],"statistical":[97],"unit":[98],"was":[99,199,373],"patient":[101],"not":[103,341,349],"unless":[106],"clustering":[108],"implants":[111,248],"within":[112],"patients":[114,238,281,316,390],"had":[115],"been":[116],"taken":[117],"into":[118],"account.":[119],"Results":[120],"expressed":[122],"as":[123],"random-effects":[124],"models":[125],"using":[126,422],"mean":[127,251],"differences":[128,210],"continuous":[130],"outcomes":[131,137],"risk":[133,205,225,357,403],"ratios":[134],"dichotomous":[136],"with":[138,282,289,318,375,424,502],"95%":[139],"confidence":[140],"intervals":[141],"(CI).":[142],"RESULTS:":[143],"Fifteen":[144],"identified,":[148],"but":[149],"six":[150],"excluded.":[152],"following":[154],"compared":[157,314,427],"nine":[160],"included":[161],"studies:":[162],"different":[163,176],"non-surgical":[164,171],"(five":[166],"trials),":[167],"adjunctive":[168,182,231],"treatments":[169,183],"(one":[173,187],"trial),":[174],"surgical":[177,185],"(two":[179],"trials)":[180],"trial).":[188],"Follow-up":[189,465],"ranged":[190],"from":[191,440],"3":[192],"months":[193],"4":[195,229,279,409],"years.":[196],"No":[197],"study":[198],"judged":[200,218],"be":[202,220,331,491,497],"at":[203,221,241,355,401],"low":[204],"bias.":[207,227],"Statistically":[208],"significant":[209],"observed":[212],"small":[215,353,398],"single":[216,352,399],"unclear":[222,356],"high":[224,402],"After":[228,278],"months,":[230],"local":[232,365],"antibiotics":[233,366],"manual":[235,370],"debridement":[236,372],"who":[239],"lost":[240],"least":[242],"50%":[243],"showed":[249,294,360,406],"improved":[250,411],"probing":[252,266],"attachment":[253],"levels":[254],"(PAL)":[255],"0.61":[257],"mm":[258,272,287,299,378,418],"(95%":[259,273,302,309],"CI":[260,274,303,310],"0.40":[261],"0.82)":[263],"reduced":[265],"pockets":[267],"depths":[268],"(PPD)":[269],"0.59":[271],"0.39":[275],"0.79).":[277],"years,":[280,410],"periimplant":[283],"infrabony":[284,434],"defects":[285],">3":[286],"treated":[288,317,480],"Bio-Oss":[290,423],"resorbable":[292,425],"barriers":[293,426],"an":[295],"improvement":[296,380],"1.4":[298,417],"PAL":[301,382,412],"0.24":[304],"2.56)":[306],"PPD":[308,384,414],"0.81":[311],"1.99)":[313],"a":[319,376,386,429,492],"nanocrystalline":[320,430],"hydroxyapatite.":[321],"CONCLUSIONS:":[322],"There":[323,436],"is":[324,340,437],"no":[325,438],"reliable":[326],"evidence":[327,439],"suggesting":[328],"which":[329,457],"could":[330],"This":[339],"say":[343],"that":[344,361,407,443],"currently":[345],"used":[346],"are":[348,508],"effective.":[350],"A":[351],"trial":[354,400],"bias":[359,405],"use":[363],"addition":[368],"subgingival":[371,462],"associated":[374],"0.6":[377],"additional":[379],"over":[385],"4-month":[387],"period":[388],"affected":[391],"severe":[393],"forms":[394],"Another":[397],"after":[408],"about":[416],"obtained":[420],"when":[421],"hydroxyapatite":[431],"peri-implant":[433],"defects.":[435],"four":[441],"more":[445,451],"complex":[446],"expensive":[448],"therapies":[449],"beneficial":[452],"than":[453,467,505],"control":[455],"therapies,":[456],"basically":[458],"consisted":[459],"simple":[461],"mechanical":[463],"debridement.":[464],"longer":[466,504],"1":[468,506],"year":[469,507],"suggested":[470],"100%":[477],"cases":[481],"some":[483],"tested":[486],"interventions.":[487],"As":[488],"this":[489],"can":[490],"chronic":[493],"disease,":[494],"re-treatment":[495],"may":[496],"necessary.":[498],"Larger":[499],"well-designed":[500],"RCTs":[501],"follow-ups":[503],"needed.":[509]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":12}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
