{"id":"https://openalex.org/W593897996","doi":null,"title":"Effets toxiques d'herbicides \u00e0 base de glyphosate sur la r\u00e9gulation du cycle cellulaire et le d\u00e9veloppement pr\u00e9coce en utilisant l'embryon d'oursin","display_name":"Effets toxiques d'herbicides \u00e0 base de glyphosate sur la r\u00e9gulation du cycle cellulaire et le d\u00e9veloppement pr\u00e9coce en utilisant l'embryon d'oursin","publication_year":2004,"publication_date":"2004-09-10","ids":{"openalex":"https://openalex.org/W593897996","mag":"593897996"},"language":"fr","primary_location":{"id":"pmh:oai:HAL:tel-01117570v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/tel-01117570","pdf_url":"https://hal.sorbonne-universite.fr/tel-01117570v1/file/marc.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicologie. Rennes 1, 2004. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.sorbonne-universite.fr/tel-01117570v1/file/marc.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111556020","display_name":"Julie Marc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087003","display_name":"Laboratoire de Biologie Int\u00e9grative des Mod\u00e8les Marins","ror":"https://ror.org/001c8pb03","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2802436875","https://openalex.org/I39804081","https://openalex.org/I4210087003","https://openalex.org/I4210096427","https://openalex.org/I4210107625"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Julie Marc","raw_affiliation_strings":["Laboratoire de Biologie Int\u00e9grative des Mod\u00e8les Marins"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie Int\u00e9grative des Mod\u00e8les Marins","institution_ids":["https://openalex.org/I4210087003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111556020"],"corresponding_institution_ids":["https://openalex.org/I4210087003"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.3840000033378601,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.3840000033378601,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.19269999861717224,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glyphosate","display_name":"glyphosate","score":0.9549999833106995},{"id":"https://openalex.org/keywords/herbicide-toxicity","display_name":"herbicide toxicity","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sea-urchin-embryo","display_name":"sea urchin embryo","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/early-embryonic-development","display_name":"early embryonic development","score":0.8299999833106995},{"id":"https://openalex.org/keywords/g2-m-transition","display_name":"G2/M transition","score":0.7799999713897705},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/transcriptional-dysregulation","display_name":"transcriptional dysregulation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/roundup","display_name":"Roundup","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5633307695388794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3785955011844635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34144502878189087}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:HAL:tel-01117570v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/tel-01117570","pdf_url":"https://hal.sorbonne-universite.fr/tel-01117570v1/file/marc.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicologie. Rennes 1, 2004. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:hdl:10068/753741","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/753741","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:593897996","doi":null,"is_oa":false,"landing_page_url":"http://hal.upmc.fr/tel-01117570","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:tel-01117570v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/tel-01117570","pdf_url":"https://hal.sorbonne-universite.fr/tel-01117570v1/file/marc.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicologie. Rennes 1, 2004. Fran\u00e7ais. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W593897996.pdf","grobid_xml":"https://content.openalex.org/works/W593897996.grobid-xml"},"referenced_works_count":253,"referenced_works":["https://openalex.org/W11746033","https://openalex.org/W34776290","https://openalex.org/W84518793","https://openalex.org/W96091379","https://openalex.org/W100878181","https://openalex.org/W122980870","https://openalex.org/W124931762","https://openalex.org/W126363341","https://openalex.org/W129634405","https://openalex.org/W171936907","https://openalex.org/W609998551","https://openalex.org/W1483839132","https://openalex.org/W1494248298","https://openalex.org/W1506378798","https://openalex.org/W1513726945","https://openalex.org/W1521417371","https://openalex.org/W1529783836","https://openalex.org/W1531747712","https://openalex.org/W1542558659","https://openalex.org/W1544564404","https://openalex.org/W1558989936","https://openalex.org/W1562338683","https://openalex.org/W1563500132","https://openalex.org/W1594985705","https://openalex.org/W1599979091","https://openalex.org/W1603059344","https://openalex.org/W1709867883","https://openalex.org/W1723327061","https://openalex.org/W1744830096","https://openalex.org/W1778387444","https://openalex.org/W1849680308","https://openalex.org/W1877319834","https://openalex.org/W1888003329","https://openalex.org/W1914194999","https://openalex.org/W1943010247","https://openalex.org/W1952982568","https://openalex.org/W1963712136","https://openalex.org/W1964511352","https://openalex.org/W1964963207","https://openalex.org/W1965390803","https://openalex.org/W1965756219","https://openalex.org/W1966532367","https://openalex.org/W1968144640","https://openalex.org/W1968201777","https://openalex.org/W1968268257","https://openalex.org/W1969939692","https://openalex.org/W1970256522","https://openalex.org/W1971079672","https://openalex.org/W1971732278","https://openalex.org/W1972091482","https://openalex.org/W1972925423","https://openalex.org/W1974791555","https://openalex.org/W1975931639","https://openalex.org/W1976397353","https://openalex.org/W1976558883","https://openalex.org/W1978374026","https://openalex.org/W1979915115","https://openalex.org/W1981341970","https://openalex.org/W1982115709","https://openalex.org/W1982607151","https://openalex.org/W1983018722","https://openalex.org/W1983972534","https://openalex.org/W1984028352","https://openalex.org/W1985182356","https://openalex.org/W1985844240","https://openalex.org/W1986148855","https://openalex.org/W1987163070","https://openalex.org/W1990830210","https://openalex.org/W1992195472","https://openalex.org/W1992848268","https://openalex.org/W1993620782","https://openalex.org/W1995254753","https://openalex.org/W1996044367","https://openalex.org/W1996711598","https://openalex.org/W1997643531","https://openalex.org/W1997759534","https://openalex.org/W1998057027","https://openalex.org/W1999866626","https://openalex.org/W2000146554","https://openalex.org/W2002114666","https://openalex.org/W2002899511","https://openalex.org/W2003082106","https://openalex.org/W2004313732","https://openalex.org/W2005391118","https://openalex.org/W2005894352","https://openalex.org/W2006303534","https://openalex.org/W2008423232","https://openalex.org/W2008693579","https://openalex.org/W2010281502","https://openalex.org/W2010452319","https://openalex.org/W2012015317","https://openalex.org/W2012482335","https://openalex.org/W2012672784","https://openalex.org/W2012869876","https://openalex.org/W2013282241","https://openalex.org/W2013714072","https://openalex.org/W2013993442","https://openalex.org/W2014445311","https://openalex.org/W2015108163","https://openalex.org/W2015446431","https://openalex.org/W2015537283","https://openalex.org/W2016769893","https://openalex.org/W2018614002","https://openalex.org/W2019237376","https://openalex.org/W2020676488","https://openalex.org/W2021505095","https://openalex.org/W2023602283","https://openalex.org/W2023827302","https://openalex.org/W2024382915","https://openalex.org/W2025465341","https://openalex.org/W2027376766","https://openalex.org/W2029466526","https://openalex.org/W2029479878","https://openalex.org/W2029497249","https://openalex.org/W2031153472","https://openalex.org/W2031541849","https://openalex.org/W2033396306","https://openalex.org/W2034419242","https://openalex.org/W2034426488","https://openalex.org/W2034633607","https://openalex.org/W2035831025","https://openalex.org/W2037327661","https://openalex.org/W2038113207","https://openalex.org/W2038143768","https://openalex.org/W2038340312","https://openalex.org/W2039839254","https://openalex.org/W2042484325","https://openalex.org/W2043790677","https://openalex.org/W2044145281","https://openalex.org/W2044884232","https://openalex.org/W2046239497","https://openalex.org/W2048875557","https://openalex.org/W2049164828","https://openalex.org/W2049562411","https://openalex.org/W2050918524","https://openalex.org/W2051522390","https://openalex.org/W2051928958","https://openalex.org/W2052221882","https://openalex.org/W2054228387","https://openalex.org/W2054310345","https://openalex.org/W2059155490","https://openalex.org/W2060788204","https://openalex.org/W2061052064","https://openalex.org/W2062856695","https://openalex.org/W2063203058","https://openalex.org/W2063799595","https://openalex.org/W2064306389","https://openalex.org/W2064458964","https://openalex.org/W2066305597","https://openalex.org/W2066378387","https://openalex.org/W2066893159","https://openalex.org/W2067107892","https://openalex.org/W2067992724","https://openalex.org/W2070147996","https://openalex.org/W2070489915","https://openalex.org/W2071183649","https://openalex.org/W2072720547","https://openalex.org/W2074903637","https://openalex.org/W2075145671","https://openalex.org/W2075719209","https://openalex.org/W2075963587","https://openalex.org/W2076314401","https://openalex.org/W2076775634","https://openalex.org/W2076932702","https://openalex.org/W2077270224","https://openalex.org/W2077278757","https://openalex.org/W2080125477","https://openalex.org/W2082507134","https://openalex.org/W2083703171","https://openalex.org/W2084058766","https://openalex.org/W2085593164","https://openalex.org/W2085791143","https://openalex.org/W2086131247","https://openalex.org/W2086903352","https://openalex.org/W2089557229","https://openalex.org/W2089603504","https://openalex.org/W2089973144","https://openalex.org/W2090827556","https://openalex.org/W2091829207","https://openalex.org/W2092962351","https://openalex.org/W2096750214","https://openalex.org/W2097337430","https://openalex.org/W2102242413","https://openalex.org/W2103169642","https://openalex.org/W2103332439","https://openalex.org/W2105016405","https://openalex.org/W2105592350","https://openalex.org/W2107419808","https://openalex.org/W2108586779","https://openalex.org/W2108979392","https://openalex.org/W2109609438","https://openalex.org/W2109623711","https://openalex.org/W2109707457","https://openalex.org/W2110300087","https://openalex.org/W2111987203","https://openalex.org/W2114435526","https://openalex.org/W2114811679","https://openalex.org/W2114915425","https://openalex.org/W2115663260","https://openalex.org/W2116644216","https://openalex.org/W2117939247","https://openalex.org/W2119646277","https://openalex.org/W2120009233","https://openalex.org/W2121619780","https://openalex.org/W2122318575","https://openalex.org/W2125751525","https://openalex.org/W2126004595","https://openalex.org/W2127397312","https://openalex.org/W2128705810","https://openalex.org/W2128994729","https://openalex.org/W2129381867","https://openalex.org/W2129695021","https://openalex.org/W2130084958","https://openalex.org/W2130290124","https://openalex.org/W2131954674","https://openalex.org/W2133378734","https://openalex.org/W2133921968","https://openalex.org/W2135820065","https://openalex.org/W2137157708","https://openalex.org/W2137321384","https://openalex.org/W2140103470","https://openalex.org/W2140369540","https://openalex.org/W2140656629","https://openalex.org/W2142904932","https://openalex.org/W2144942522","https://openalex.org/W2147288798","https://openalex.org/W2147925889","https://openalex.org/W2147963427","https://openalex.org/W2147971204","https://openalex.org/W2151348630","https://openalex.org/W2153451248","https://openalex.org/W2154247747","https://openalex.org/W2159630851","https://openalex.org/W2160190028","https://openalex.org/W2162418284","https://openalex.org/W2162993621","https://openalex.org/W2165002050","https://openalex.org/W2169927110","https://openalex.org/W2170678181","https://openalex.org/W2170944181","https://openalex.org/W2188252613","https://openalex.org/W2235427389","https://openalex.org/W2237217492","https://openalex.org/W2324660863","https://openalex.org/W2398382373","https://openalex.org/W2410629393","https://openalex.org/W2412057364","https://openalex.org/W2416926240","https://openalex.org/W2460827171","https://openalex.org/W2470697986","https://openalex.org/W2478409626","https://openalex.org/W2483651165","https://openalex.org/W2515003624"],"related_works":["https://openalex.org/W2154247747","https://openalex.org/W3043733604","https://openalex.org/W1978374026","https://openalex.org/W7067256206","https://openalex.org/W2734653979","https://openalex.org/W366874168","https://openalex.org/W2530099513","https://openalex.org/W2168130144","https://openalex.org/W2582638370","https://openalex.org/W2128173229"],"abstract_inverted_index":{"L'utilisation":[0],"du":[1,16,20,33,41,57,78,93],"d\u00e9veloppement":[2,21,94],"pr\u00e9coce":[3,96],"de":[4,9,44,61,66,68,101,109,123],"l'oursin":[5],"nous":[6,82],"a":[7],"permis":[8],"mettre":[10],"en":[11,46,85,97,107,121],"\u00e9vidence":[12,86],"des":[13,91,114],"dysfonctionnements":[14,92],"sp\u00e9cifiques":[15],"cycle":[17,79],"cellulaire":[18],"et":[19,74,116],"pr\u00e9coce.":[22],"Nous":[23],"montrons":[24],"que":[25,87],"le":[26,49,76,88,99],"roundup":[27,58,89,110],"provoque":[28,75,90],"un":[29],"d\u00e9lai":[30],"dans":[31],"l'apparition":[32],"premier":[34],"clivage":[35],"mitotique":[36],";":[37],"il":[38],"retarde":[39],"l'activation":[40],"complexe":[42,50],"r\u00e9gulateur":[43],"l'entr\u00e9e":[45],"phase":[47],"M,":[48],"CDK/cycline":[51],"B.":[52],"La":[53],"cible":[54],"mol\u00e9culaire":[55],"initiale":[56],"est":[59],"l'activit\u00e9":[60],"synth\u00e8se":[62],"d'ADN.":[63],"Le":[64],"m\u00e9canisme":[65,100],"surveillance":[67],"la":[69],"transition":[70],"G2M":[71],"d\u00e9tecte":[72],"l'anomalie":[73],"retard":[77],"cellulaire.":[80],"Parall\u00e8lement,":[81],"avons":[83],"mis":[84],"embryonnaire":[95],"affectant":[98],"transcription.":[102],"Les":[103],"deux":[104],"effets":[105],"d\u00e9crits":[106],"pr\u00e9sence":[108],"sont":[111],"asoci\u00e9s":[112],"\u00e0":[113],"pathologies":[115],"leur":[117],"existence":[118],"pose":[119],"probl\u00e8me":[120],"terme":[122],"sant\u00e9":[124],"humaine":[125]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2016-06-24T00:00:00"}