{"id":"https://openalex.org/W593860738","doi":null,"title":"On the issue of drug washout prior to polysomnographic studies in depressed patients.","display_name":"On the issue of drug washout prior to polysomnographic studies in depressed patients.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W593860738","mag":"593860738","pmid":"https://pubmed.ncbi.nlm.nih.gov/1349209"},"language":"en","primary_location":{"id":"pmid:1349209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1349209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108209028","display_name":"Christoph Johannes Lauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C J Lauer","raw_affiliation_strings":["Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067474389","display_name":"Thomas Pollm\u00e4cher","orcid":"https://orcid.org/0009-0008-1790-7588","observed_orcids":["https://orcid.org/0009-0008-1790-7588"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Pollm\u00e4cher","raw_affiliation_strings":["Max Planck Institute of Psychiatry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute of Psychiatry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0936,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.94002665,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"1","first_page":"11","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.07729999721050262,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-washout","display_name":"drug washout","score":0.9610000252723694},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6729999780654907},{"id":"https://openalex.org/keywords/polysomnography","display_name":"polysomnography","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sleep-eeg","display_name":"sleep EEG","score":0.7149999737739563},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9879999756813049},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":1.0},{"id":"https://openalex.org/keywords/sleep-architecture","display_name":"sleep architecture","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C71839028","wikidata":"https://www.wikidata.org/wiki/Q7972627","display_name":"Washout","level":2,"score":0.6351791024208069},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5684216618537903},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5434144139289856},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.533467710018158},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.4659838080406189},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4280554950237274},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4150148630142212},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3928717374801636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1984773874282837}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:1349209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1349209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mpg.de:461267","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/461267","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuropsychopharmacology, v.6, 11-16 (1992)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_1629997","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-000E-86B9-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuropsychopharmacology","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:593860738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1349209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086238232","https://openalex.org/W2051036034","https://openalex.org/W2414868021","https://openalex.org/W4231977058","https://openalex.org/W2039465869","https://openalex.org/W1988561921","https://openalex.org/W2462815664","https://openalex.org/W1982662707","https://openalex.org/W2418223925","https://openalex.org/W2037166692"],"abstract_inverted_index":{"In":[0,27,87],"psychoneurobiological":[1],"studies":[2],"it":[3],"is":[4,43],"a":[5,50,69,97],"point":[6],"of":[7,33,40,54,72,94,108],"controversy":[8],"how":[9],"long":[10],"psychoactive":[11,41,110],"medication":[12,42,111],"has":[13],"to":[14,17,24,29,104],"be":[15,25,102],"withdrawn":[16],"exclude":[18,105],"drug":[19,81,99],"effects":[20,82,107],"on":[21,83,112],"the":[22,31,35,89,92],"variables":[23],"investigated.":[26],"order":[28],"answer":[30],"question":[32,93],"whether":[34,95],"generally":[36],"assumed":[37],"two-week":[38],"washout":[39,100],"sufficient":[44,103],"for":[45],"polysomnographic":[46],"studies,":[47],"we":[48],"computed":[49],"post":[51],"hoc":[52],"analysis":[53],"EEG":[55,113],"sleep":[56],"recordings":[57],"in":[58],"61":[59],"newly":[60],"admitted":[61],"depressed":[62],"patients.":[63],"The":[64],"results":[65],"indicate":[66],"that":[67],"after":[68],"2-week":[70],"withdrawal":[71],"tricyclic":[73],"antidepressants":[74],"and/or":[75],"benzodiazepines":[76],"there":[77],"are":[78],"no":[79],"major":[80],"visually":[84],"scored":[85],"polysomnograms.":[86],"addition,":[88],"observations":[90],"raise":[91],"even":[96],"1-week":[98],"may":[101],"confounding":[106],"prior":[109],"sleep.":[114]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}