{"id":"https://openalex.org/W59326420","doi":null,"title":"Preventing nonvertebral osteoporotic fractures with extended-interval bisphosphonates: regimen selection and clinical application.","display_name":"Preventing nonvertebral osteoporotic fractures with extended-interval bisphosphonates: regimen selection and clinical application.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W59326420","mag":"59326420","pmid":"https://pubmed.ncbi.nlm.nih.gov/19295933","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2654682"},"language":"en","primary_location":{"id":"pmid:19295933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19295933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medscape journal of medicine","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2654682/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007715313","display_name":"Raymond E Cole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond E Cole","raw_affiliation_strings":["Department of Internal Medicine, Michigan State University College of Osteopathic Medicine, Michigan, USA. Recfcc@aol.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Michigan State University College of Osteopathic Medicine, Michigan, USA. Recfcc@aol.com","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047122819","display_name":"Steven T. Harris","orcid":"https://orcid.org/0000-0002-2342-9964","observed_orcids":["https://orcid.org/0000-0002-2342-9964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven T Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3623,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.3024055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"11","issue":"1","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibandronate","display_name":"ibandronate","score":0.8119999766349792},{"id":"https://openalex.org/keywords/risedronate","display_name":"risedronate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":1.0},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7490000128746033},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.8930000066757202},{"id":"https://openalex.org/keywords/fracture-prevention","display_name":"fracture prevention","score":0.5049999952316284},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hip-fracture","display_name":"hip fracture","score":0.6570000052452087},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8231186866760254},{"id":"https://openalex.org/C2776326535","wikidata":"https://www.wikidata.org/wiki/Q218507","display_name":"Zoledronic acid","level":2,"score":0.7427915930747986},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6864800453186035},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.666294515132904},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6604312062263489},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6040730476379395},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5905633568763733},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5013864040374756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46575552225112915},{"id":"https://openalex.org/C2778885795","wikidata":"https://www.wikidata.org/wiki/Q240856","display_name":"Hip fracture","level":3,"score":0.4612407386302948},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4480399191379547},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44420331716537476},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4261436462402344},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.05695939064025879},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:19295933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19295933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medscape journal of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2654682","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2654682/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medscape J Med","raw_type":"Text"},{"id":"mag:59326420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19295933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2654682","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2654682/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medscape J Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W51825763","https://openalex.org/W1823423766","https://openalex.org/W1941723515","https://openalex.org/W1966391931","https://openalex.org/W1966722256","https://openalex.org/W1967678736","https://openalex.org/W1973356978","https://openalex.org/W1976900035","https://openalex.org/W1977912628","https://openalex.org/W1984597244","https://openalex.org/W1989637027","https://openalex.org/W1993035292","https://openalex.org/W1995634245","https://openalex.org/W1996009039","https://openalex.org/W2009508470","https://openalex.org/W2011591829","https://openalex.org/W2013724724","https://openalex.org/W2016874382","https://openalex.org/W2019018649","https://openalex.org/W2021914683","https://openalex.org/W2026123506","https://openalex.org/W2028773140","https://openalex.org/W2040116426","https://openalex.org/W2046286698","https://openalex.org/W2048541373","https://openalex.org/W2059049359","https://openalex.org/W2059857909","https://openalex.org/W2067007847","https://openalex.org/W2082716372","https://openalex.org/W2085517891","https://openalex.org/W2097085104","https://openalex.org/W2099054178","https://openalex.org/W2102123887","https://openalex.org/W2106649747","https://openalex.org/W2108258946","https://openalex.org/W2108275539","https://openalex.org/W2109465803","https://openalex.org/W2110768118","https://openalex.org/W2111387898","https://openalex.org/W2111925158","https://openalex.org/W2118040100","https://openalex.org/W2120433336","https://openalex.org/W2139796029","https://openalex.org/W2147255557","https://openalex.org/W2150147443","https://openalex.org/W2150904792","https://openalex.org/W2158943274","https://openalex.org/W2163830908","https://openalex.org/W2168551344","https://openalex.org/W2399708800"],"related_works":["https://openalex.org/W2138186944","https://openalex.org/W2020430025","https://openalex.org/W1985025026","https://openalex.org/W1932931821","https://openalex.org/W1913264660","https://openalex.org/W2095278422","https://openalex.org/W2099054178","https://openalex.org/W2058565184","https://openalex.org/W2055352250","https://openalex.org/W2064580477"],"abstract_inverted_index":{"CONTEXT:":[0],"Nonvertebral":[1],"fractures":[2],"(NVFs)":[3],"are":[4],"the":[5,18],"most":[6],"costly":[7],"and":[8,29,46,73,98,118,125,132,145,159,196,236,240,252],"disabling":[9],"type":[10],"of":[11,75,110,121,178],"osteoporotic":[12],"fractures.":[13],"Bisphosphonate":[14],"therapy":[15],"effectively":[16],"reduces":[17],"risk":[19,138,193,199],"for":[20,58,67,209],"NVFs;":[21],"however,":[22],"fracture":[23,48,198],"protection":[24,49,220],"depends":[25],"critically":[26],"on":[27,44],"adherence":[28,235],"persistence.":[30],"Approved":[31],"bisphosphonate":[32,78,242],"regimens":[33,79,243],"with":[34,61,80,172,203,221,226],"extended":[35],"dosing":[36,85],"intervals":[37],"increase":[38],"patient":[39],"convenience,":[40],"help":[41],"patients":[42],"remain":[43],"therapy,":[45],"improve":[47],"in":[50,205],"clinical":[51,70],"practice.":[52],"EVIDENCE":[53,128],"ACQUISITION:":[54],"To":[55],"assess":[56],"evidence":[57],"NVF":[59,137,192,219,254],"reduction":[60],"extended-interval":[62,238],"bisphosphonates,":[63],"we":[64],"searched":[65],"PubMed":[66],"phase":[68],"3":[69],"trials,":[71],"meta-analyses,":[72],"reviews":[74],"approved":[76],"nitrogen-containing":[77],"monthly":[81,89,160],"or":[82,90,217,228],"less":[83,222],"frequent":[84],"(monthly":[86],"oral":[87,92,131,143,161,174,239],"ibandronate,":[88,97],"intermittent":[91],"risedronate,":[93],"quarterly":[94,133],"intravenous":[95],"[IV]":[96],"yearly":[99],"IV":[100,134,188,241],"zoledronic":[101,189],"acid).":[102],"These":[103],"references":[104],"were":[105,184],"augmented":[106],"by":[107,149,152,194,200],"ISI":[108,115],"Web":[109],"Science":[111],"cited":[112],"reference":[113],"searches,":[114,117],"Proceedings":[116],"hand":[119],"searches":[120],"relevant":[122],"conference":[123],"proceedings":[124],"review":[126],"bibliographies.":[127],"SYNTHESIS:":[129],"Monthly":[130],"ibandronate":[135,144,153],"reduce":[136,253],"significantly":[139],"more":[140],"than":[141],"daily":[142,173,227],"placebo,":[146],"as":[147,181],"shown":[148,164],"meta-analyses":[150],"stratified":[151],"dose":[154],"(annual":[155],"cumulative":[156],"exposure).":[157],"Intermittent":[158],"risedronate":[162],"have":[163],"bone":[165],"density":[166],"gains":[167],"similar":[168,216],"to":[169,234,248],"those":[170],"seen":[171],"risedronate.":[175],"Incidence":[176],"rates":[177],"NVF,":[179],"reported":[180],"adverse":[182],"events,":[183],"also":[185],"similar.":[186],"Yearly":[187],"acid":[190],"reduced":[191],"25%":[195],"hip":[197],"41%":[201],"compared":[202,225],"placebo":[204],"its":[206],"pivotal":[207],"trial":[208],"postmenopausal":[210],"osteoporosis.":[211],"CONCLUSIONS:":[212],"Extended-interval":[213],"bisphosphonates":[214],"offer":[215],"superior":[218],"lifestyle":[223],"disruption":[224],"weekly":[229],"treatment.":[230],"By":[231],"removing":[232],"obstacles":[233],"persistence,":[237],"provide":[244],"valuable":[245],"therapeutic":[246],"options":[247],"enhance":[249],"real-world":[250],"effectiveness":[251],"incidence.":[255]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
