{"id":"https://openalex.org/W592558673","doi":null,"title":"Immunological and behavioral consequences of high-fat diet feeding in mice","display_name":"Immunological and behavioral consequences of high-fat diet feeding in mice","publication_year":2010,"publication_date":"2010-05-18","ids":{"openalex":"https://openalex.org/W592558673","mag":"592558673"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/15982","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/15982","pdf_url":"https://www.ideals.illinois.edu/items/16040/bitstreams/57235/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/16040/bitstreams/57235/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061643601","display_name":"Desiree N. Lavin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Desiree N. Lavin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061643601"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05156382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9810000061988831},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anhedonia","display_name":"anhedonia","score":0.8429999947547913},{"id":"https://openalex.org/keywords/saccharin-preference","display_name":"saccharin preference","score":0.9409999847412109},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.6430000066757202},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8190000057220459},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.9760000109672546},{"id":"https://openalex.org/keywords/leptin-resistance","display_name":"leptin resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6359999775886536},{"id":"https://openalex.org/keywords/reward-motivation","display_name":"reward motivation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.8539999723434448},{"id":"https://openalex.org/keywords/burrowing-behavior","display_name":"burrowing behavior","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sucrose-intake","display_name":"sucrose intake","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C3017650416","wikidata":"https://www.wikidata.org/wiki/Q3281331","display_name":"Feeding behavior","level":2,"score":0.5063351392745972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4207685589790344},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.39647430181503296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35705921053886414},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3522622883319855},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32465386390686035},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.3017790913581848}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/15982","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/15982","pdf_url":"https://www.ideals.illinois.edu/items/16040/bitstreams/57235/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1028.1891","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1028.1891","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.ideals.illinois.edu/bitstream/handle/2142/15982/Lavin_Desiree.pdf?sequence%3D2","raw_type":"text"},{"id":"mag:592558673","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/15982","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/15982","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/15982","pdf_url":"https://www.ideals.illinois.edu/items/16040/bitstreams/57235/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W592558673.pdf","grobid_xml":"https://content.openalex.org/works/W592558673.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W49677012","https://openalex.org/W72976067","https://openalex.org/W91600810","https://openalex.org/W1504775902","https://openalex.org/W1514081838","https://openalex.org/W1594976448","https://openalex.org/W1631449371","https://openalex.org/W1675314858","https://openalex.org/W1677069120","https://openalex.org/W1936533727","https://openalex.org/W1961990310","https://openalex.org/W1963690512","https://openalex.org/W1966523374","https://openalex.org/W1968748189","https://openalex.org/W1970022478","https://openalex.org/W1970790819","https://openalex.org/W1972779667","https://openalex.org/W1974760551","https://openalex.org/W1977915489","https://openalex.org/W1978180139","https://openalex.org/W1979269668","https://openalex.org/W1981118821","https://openalex.org/W1981466881","https://openalex.org/W1984735526","https://openalex.org/W1986608520","https://openalex.org/W1991810873","https://openalex.org/W1991882271","https://openalex.org/W1992162538","https://openalex.org/W1993790199","https://openalex.org/W1995300425","https://openalex.org/W1996713062","https://openalex.org/W2001585610","https://openalex.org/W2001809220","https://openalex.org/W2002250647","https://openalex.org/W2006313514","https://openalex.org/W2006944478","https://openalex.org/W2006949877","https://openalex.org/W2008869160","https://openalex.org/W2009590767","https://openalex.org/W2011823591","https://openalex.org/W2013524799","https://openalex.org/W2014093920","https://openalex.org/W2014163208","https://openalex.org/W2015072700","https://openalex.org/W2015591615","https://openalex.org/W2015611430","https://openalex.org/W2015918699","https://openalex.org/W2019371323","https://openalex.org/W2019752999","https://openalex.org/W2021045520","https://openalex.org/W2034520471","https://openalex.org/W2035121795","https://openalex.org/W2035421865","https://openalex.org/W2036126766","https://openalex.org/W2037111632","https://openalex.org/W2038081789","https://openalex.org/W2039578408","https://openalex.org/W2042893069","https://openalex.org/W2049927826","https://openalex.org/W2050037580","https://openalex.org/W2050209877","https://openalex.org/W2054028567","https://openalex.org/W2054492621","https://openalex.org/W2055747883","https://openalex.org/W2055956383","https://openalex.org/W2056352776","https://openalex.org/W2056383195","https://openalex.org/W2057119181","https://openalex.org/W2057200138","https://openalex.org/W2062680000","https://openalex.org/W2065906084","https://openalex.org/W2067183464","https://openalex.org/W2068186755","https://openalex.org/W2069038722","https://openalex.org/W2069303582","https://openalex.org/W2071070948","https://openalex.org/W2073598149","https://openalex.org/W2074229539","https://openalex.org/W2077321360","https://openalex.org/W2080776733","https://openalex.org/W2081595033","https://openalex.org/W2082743978","https://openalex.org/W2084622089","https://openalex.org/W2086068975","https://openalex.org/W2087133453","https://openalex.org/W2090977677","https://openalex.org/W2091087465","https://openalex.org/W2091144676","https://openalex.org/W2092098972","https://openalex.org/W2093624220","https://openalex.org/W2098870010","https://openalex.org/W2101299835","https://openalex.org/W2105105112","https://openalex.org/W2109311297","https://openalex.org/W2114140914","https://openalex.org/W2114207481","https://openalex.org/W2120279490","https://openalex.org/W2121614675","https://openalex.org/W2125510262","https://openalex.org/W2126795224","https://openalex.org/W2129316761","https://openalex.org/W2136024338","https://openalex.org/W2142444233","https://openalex.org/W2144150240","https://openalex.org/W2144466510","https://openalex.org/W2149271886","https://openalex.org/W2149372470","https://openalex.org/W2151566924","https://openalex.org/W2153646267","https://openalex.org/W2154502881","https://openalex.org/W2161001082","https://openalex.org/W2162472958","https://openalex.org/W2164125772","https://openalex.org/W2165345254","https://openalex.org/W2168182154","https://openalex.org/W2170378836","https://openalex.org/W2206659032","https://openalex.org/W2278747333","https://openalex.org/W2341830035","https://openalex.org/W2514742695"],"related_works":["https://openalex.org/W97403023","https://openalex.org/W3084058059","https://openalex.org/W2521664939","https://openalex.org/W2290974786","https://openalex.org/W2080455415","https://openalex.org/W2008687046","https://openalex.org/W2083283411","https://openalex.org/W3016048902","https://openalex.org/W2136217317","https://openalex.org/W2016853878"],"abstract_inverted_index":{"Obesity":[0],"is":[1,26],"a":[2,27,37,43,57,75,86,215,228,306,503,512,522,577,594],"harmful":[3],"and":[4,23,114,128,135,163,166,189,204,221,245,266,272,275,300,337,368,437,478,483,493,590],"costly":[5],"condition":[6],"which":[7],"continues":[8],"to":[9,62,72,95,148,160,184,321,383,397,423,448,495,507,527,537,540,552,587],"increase":[10,288],"in":[11,34,41,66,121,140,171,193,212,236,250,257,270,289,294,318,323,341,359,392,418,469,497,500,514,579,597,609],"prevalence.":[12],"Co-morbidities":[13],"accompanying":[14],"this":[15,351],"disease":[16],"include":[17],"brain-based":[18],"disorders":[19],"that":[20,32,53,131,467,484,556,576,591,601],"impact":[21],"cognition":[22],"mood.":[24],"Anhedonia":[25],"biobehavior":[28],"associated":[29,155],"with":[30,156],"depression":[31],"manifests":[33],"mice":[35,55,73,84,141,149,213,277,381,393,398,419,424,501,519,528,533,546,555,598],"as":[36,106],"loss":[38],"of":[39,89,158,174,473,559,582],"interest":[40,65],"consuming":[42],"highly":[44],"palatable":[45],"sucrose":[46],"or":[47,241],"saccharin":[48,67,92,99,187,498,515,523,538,549,566,588],"solution.":[49],"Here":[50],"we":[51,197],"show":[52,466],"obese":[54],"fed":[56,74,142,150,203,214,239,271,325,344,360,394,399,420,425,450,502,529,599],"high-fat":[58],"diet":[59,77],"(HFD),":[60],"fail":[61],"exhibit":[63],"an":[64,535],"(27%":[68],"vs":[69,100,218,224,298,303,330,345,348,364,373,455],"74%)":[70],"compared":[71,147,320,382,396,422,447,539,551],"low-fat":[76],"(LFD)":[78],"(p":[79,310,334,568],"<":[80,311,335,378,409,435,460,569],"0.007).":[81],"When":[82],"HFD":[83,122,143,195,216,242,274,301,319,343,380,395,421,600],"undergo":[85],"fasting":[87,120,391,417,442,592],"period":[88],"24":[90,307],"hours,":[91],"preferences":[93],"equilibrate":[94],"water":[96],"consumption":[97,188],"(51%":[98],"49%":[101],"water).":[102],"Other":[103],"behaviors":[104,191],"such":[105],"immobility":[107],"during":[108,201,390,441,481],"the":[109,172,185,202,324,342,444,610],"forced":[110],"swim":[111],"test":[112],"(FST)":[113],"burrowing":[115],"behavior":[116],"are":[117,138],"improved":[118],"by":[119,439,490],"mice.":[123,385,543],"We":[124,253],"have":[125],"previously":[126],"shown":[127],"demonstrate":[129],"here":[130],"basal":[132],"serum":[133,199],"leptin":[134,176,259,290,607],"IL-1RA":[136,167,231,313,479,510,517,531,544,584],"concentrations":[137,200],"increased":[139,186,316,414,606],"for":[144],"12":[145],"weeks":[146],"LFD.":[151],"Leptin":[152,207],"has":[153,168,593],"been":[154,169],"modulation":[157],"motivation":[159],"obtain":[161],"reward":[162],"anti-depressant":[164],"activity,":[165],"implicated":[170],"mediation":[173],"central":[175],"resistance.":[177],"To":[178],"examine":[179],"if":[180,509],"these":[181,464,485,573],"cytokines":[182],"contributed":[183],"other":[190],"observed":[192],"fasted":[194,205,273,346,369],"mice,":[196],"measured":[198],"states.":[206],"decreased,":[208],"although":[209],"not":[210,233,248,353],"significantly,":[211],"(43,844":[217],"42,791":[219],"pg/mL)":[220,226],"LFD":[222,240,276,296,322,384,400,426,445],"(8,118":[223],"3,104":[225],"after":[227,305,416],"24-hour":[229],"fast.":[230],"did":[232],"significantly":[234],"change":[235],"either":[237],"group":[238,446],"when":[243],"fasted,":[244],"IL-1\u03b2":[246,267],"was":[247,292,315,352,357,388,413],"detectable":[249],"any":[251],"group.":[252],"further":[254],"investigated":[255],"differences":[256,496],"leptin,":[258,474],"receptor":[260],"(LepR),":[261],"IL-1RA,":[262],"IL-1R1,":[263],"IL-1R2,":[264,476],"IL1\u03b1":[265],"brain":[268,470,583],"expression":[269,284,291,314,356,387,412,472,608],"utilizing":[278],"real-time":[279],"PCR":[280],"(RT":[281],"PCR)":[282],"gene":[283,471],"analysis.":[285],"A":[286],"2-fold":[287],"seen":[293],"both":[295],"(1":[297,327],"2)":[299],"(2":[302],"4)":[304],"hour":[308],"fast":[309],"0.05).":[312,461],"2.3-fold":[317],"state":[326,451],"\u00b1":[328,332,362,366,371,375,402,406,428,432,453,457],"0.31":[329],"2.26":[331],"0.66)":[333],"0.05)":[336,379,436],"trended":[338],"toward":[339],"increasing":[340],"(1.89":[347],"4.16)":[349],"but":[350],"significant.":[354],"IL-1R1":[355,477],"decreased":[358,389,438],"(0.79":[361],"0.09":[363],"1":[365,456],"0.08)":[367],"(0.68":[370],"0.14":[372,429],"0.88":[374],"0.07;":[376],"p":[377,408,434,459],"IL-1R2":[386],"(1.013":[401],"0.12":[403],"vs.":[404,430],"1.40":[405],"0.08;":[407],"0.005).":[410,570],"IL-1\u03b1":[411],"1.5-fold":[415],"(0.923":[427],"0.59":[431],"0.15;":[433],"1.6-fold":[440],"within":[443],"its":[449],"(0.6":[452],"0.15":[454],"0.19;":[458],"Taken":[462,571],"together,":[463,572],"data":[465,574],"changes":[468,486],"IL-1\u03b1,":[475],"occur":[480],"fasting,":[482],"may":[487,585,602],"be":[488,603],"affected":[489],"nutritional":[491],"status":[492],"contribute":[494,586],"preference":[499,524],"HFD.":[504],"In":[505],"order":[506],"determine":[508],"played":[511],"role":[513],"consumption,":[516],"knockout":[518],"were":[520],"given":[521],"test.":[525],"Similar":[526],"HFD,":[530],"KO":[532,545],"had":[534],"aversion":[536],"control":[541,553],"WT":[542,554],"consumed":[547,557],"12%":[548],"solution":[550,567],"65%":[558],"their":[560],"total":[561],"daily":[562],"fluid":[563],"intake":[564],"from":[565],"indicate":[575],"deviation":[578],"normal":[580],"levels":[581],"aversion,":[589],"behavioral":[595],"benefit":[596],"reliant":[604],"on":[605],"brain.":[611]},"counts_by_year":[],"updated_date":"2026-10-18T09:31:52.927876","created_date":"2016-06-24T00:00:00"}
