{"id":"https://openalex.org/W59221692","doi":null,"title":"B16 and cloudman S91 mouse melanoma cells susceptibility to apoptosis after dacarbazine treatment.","display_name":"B16 and cloudman S91 mouse melanoma cells susceptibility to apoptosis after dacarbazine treatment.","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W59221692","mag":"59221692","pmid":"https://pubmed.ncbi.nlm.nih.gov/16583988"},"language":"en","primary_location":{"id":"pmid:16583988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16583988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta poloniae pharmaceutica","raw_type":"Journal Article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090349803","display_name":"Dorota M Olszewska-S\u0142onina","orcid":"https://orcid.org/0000-0001-9742-451X","observed_orcids":["https://orcid.org/0000-0001-9742-451X"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]},{"id":"https://openalex.org/I4210148386","display_name":"Collegium Medicum in Bydgoszcz","ror":"https://ror.org/04c5jwj47","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Dorota M Olszewska-S\u0142onina","raw_affiliation_strings":["Department of Medical Biology, Collegium Medicum, Nicolaus Copernicus University, Karlowicza 24, Bydgoszcz 85-094, Poland. dorolsze@poczta.onet.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Collegium Medicum, Nicolaus Copernicus University, Karlowicza 24, Bydgoszcz 85-094, Poland. dorolsze@poczta.onet.pl","institution_ids":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064475235","display_name":"Jan Styczy\u0144isk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Styczy\u0144isk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065569874","display_name":"Tomasz Adam Drewa","orcid":"https://orcid.org/0000-0002-5529-4320","observed_orcids":["https://orcid.org/0000-0002-5529-4320","https://orcid.org/0000-0001-5347-4136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomasz A Drewa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070816017","display_name":"Krzysztof J. Olszewski","orcid":"https://orcid.org/0000-0002-5437-2761","observed_orcids":["https://orcid.org/0000-0002-5437-2761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krzysztof J Olszewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013287013","display_name":"Rafa\u0142 Czajkowski","orcid":"https://orcid.org/0000-0003-3418-1252","observed_orcids":["https://orcid.org/0000-0003-3418-1252"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafa\u0142 Czajkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"6","first_page":"473","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dacarbazine","display_name":"dacarbazine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.765999972820282},{"id":"https://openalex.org/keywords/mouse-melanoma","display_name":"mouse melanoma","score":0.703000009059906},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tetraploidy","display_name":"tetraploidy","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8768623471260071},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.857187807559967},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.6793519854545593},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.6693642139434814},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6051133275032043},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5736366510391235},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5718896389007568},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5443978905677795},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5377315282821655},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5307471752166748},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45139333605766296},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4189506471157074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38430359959602356},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37560248374938965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31978195905685425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18096235394477844},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008858","descriptor_name":"Microscopy, Phase-Contrast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:16583988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16583988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta poloniae pharmaceutica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1552995811"],"related_works":["https://openalex.org/W2414051820","https://openalex.org/W2000352929","https://openalex.org/W2444194017","https://openalex.org/W7212258661","https://openalex.org/W2982242485","https://openalex.org/W2084640577","https://openalex.org/W4362668421","https://openalex.org/W6990762807","https://openalex.org/W2411805200","https://openalex.org/W4312910432"],"abstract_inverted_index":{"Considering":[0],"the":[1,39,61,67,70,193],"necessity":[2],"of":[3,7,26,33,41,48,50,63,72,78,94,141,151,158,176,180,212],"an":[4],"individual":[5],"choice":[6],"cytostatic":[8],"drugs":[9],"for":[10,123,161,168],"patients":[11],"with":[12],"cancer":[13],"disease":[14],"and":[15,46,52,69,80,108,125,138,165],"tumor":[16],"cells'":[17],"resistance":[18],"to":[19,24,37,59,190],"these":[20,83],"compounds,":[21],"their":[22],"ability":[23],"induction":[25,150],"apoptosis":[27,79,95,124,152,169],"should":[28],"be":[29],"investigated.":[30],"The":[31,76,148,183],"aim":[32],"this":[34],"study":[35],"was":[36,91,96,153,202],"determine":[38,60],"influence":[40],"dacarbazine":[42],"(DTIC)":[43],"on":[44],"morphology":[45],"kinetics":[47],"proliferation":[49],"B16":[51,162,184],"Cloudman":[53,170,194,205],"S91":[54,171,195,206],"cells.":[55],"It":[56],"is":[57],"important":[58],"kind":[62],"death":[64],"induced":[65,119],"by":[66,103,114],"DTIC":[68,118,131,156,177,191],"effect":[71],"a":[73],"specific":[74],"concentration.":[75],"evaluation":[77],"necrosis":[81,126],"in":[82,89,98,127,136,155,204],"two":[84],"mouse":[85],"melanoma":[86,185],"cell":[87,109,129,133,143],"lines":[88,144],"vitro":[90],"performed.":[92],"Induction":[93],"estimated":[97],"annexin":[99],"V":[100],"binding":[101],"assay":[102],"flow":[104],"cytometry.":[105],"DNA":[106],"content":[107],"cycle":[110,134],"phases":[111],"were":[112],"determined":[113],"propidium":[115],"iodide":[116],"staining.":[117],"morphological":[120],"changes":[121],"typical":[122],"both":[128,142],"lines.":[130],"caused":[132,178],"arrest":[135],"S":[137],"G2/M":[139],"phase":[140],"which":[145],"showed":[146],"hypertetraploidy.":[147],"highest":[149],"observed":[154],"concentration":[157,211],"200":[159],"microg/mL":[160,167],"cells":[163,172,186,207],"(11%)":[164],"100":[166],"(22.2%).":[173],"Higher":[174],"doses":[175],"intensification":[179],"necrotic":[181],"process.":[182],"are":[187],"more":[188,198],"sensitive":[189],"than":[192],"cells,":[196],"however":[197],"intensive":[199],"apoptotic":[200],"process":[201],"detected":[203],"already":[208],"at":[209],"lower":[210],"DTIC.":[213]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}