{"id":"https://openalex.org/W59132852","doi":"https://doi.org/10.1007/978-1-59259-005-6_5","title":"Genetic Testing in the Early Diagnosis of Alzheimer\u2019s Disease","display_name":"Genetic Testing in the Early Diagnosis of Alzheimer\u2019s Disease","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W59132852","doi":"https://doi.org/10.1007/978-1-59259-005-6_5","mag":"59132852"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-005-6_5","doi":"https://doi.org/10.1007/978-1-59259-005-6_5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-005-6_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Early Diagnosis of Alzheimer\u2019s Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2419053760","display_name":"Early Diagnosis of Alzheimer\u2019s Disease"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006645872","display_name":"Deborah Blacker","orcid":"https://orcid.org/0000-0001-6107-7376","observed_orcids":["https://orcid.org/0000-0001-6107-7376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deborah Blacker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050004777","display_name":"Rudolph E. Tanzi","orcid":"https://orcid.org/0000-0002-7032-1454","observed_orcids":["https://orcid.org/0000-0002-7032-1454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rudolph E. Tanzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0315865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"105","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.9990000128746033},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/genetic-risk-prediction","display_name":"genetic risk prediction","score":0.5759999752044678},{"id":"https://openalex.org/keywords/genetic-complexity","display_name":"genetic complexity","score":0.4860000014305115},{"id":"https://openalex.org/keywords/predictive-value","display_name":"predictive value","score":0.6449999809265137},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.4699999988079071},{"id":"https://openalex.org/keywords/asymptomatic-individuals","display_name":"asymptomatic individuals","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.8101553916931152},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7073778510093689},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4684702754020691},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.46038082242012024},{"id":"https://openalex.org/C134534832","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Predictive testing","level":3,"score":0.4269477427005768},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.41796037554740906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31630557775497437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31512829661369324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2870945334434509},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15549615025520325},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59259-005-6_5","doi":"https://doi.org/10.1007/978-1-59259-005-6_5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-005-6_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Early Diagnosis of Alzheimer\u2019s Disease","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W25163377","https://openalex.org/W1539826184","https://openalex.org/W1590499183","https://openalex.org/W1607190847","https://openalex.org/W1640428455","https://openalex.org/W1892157526","https://openalex.org/W1966406375","https://openalex.org/W1969481688","https://openalex.org/W1972509050","https://openalex.org/W1974015070","https://openalex.org/W1981554609","https://openalex.org/W1981744647","https://openalex.org/W1989178832","https://openalex.org/W1996807233","https://openalex.org/W1999631936","https://openalex.org/W1999902101","https://openalex.org/W2000548634","https://openalex.org/W2001147484","https://openalex.org/W2001210466","https://openalex.org/W2011220564","https://openalex.org/W2013669235","https://openalex.org/W2014758112","https://openalex.org/W2020706970","https://openalex.org/W2021181758","https://openalex.org/W2024631916","https://openalex.org/W2024696795","https://openalex.org/W2024737628","https://openalex.org/W2029205666","https://openalex.org/W2030623470","https://openalex.org/W2031895045","https://openalex.org/W2033356439","https://openalex.org/W2033559242","https://openalex.org/W2035176443","https://openalex.org/W2036362108","https://openalex.org/W2037917702","https://openalex.org/W2038943581","https://openalex.org/W2039821621","https://openalex.org/W2040522662","https://openalex.org/W2041981163","https://openalex.org/W2045153164","https://openalex.org/W2046209489","https://openalex.org/W2055464748","https://openalex.org/W2056046302","https://openalex.org/W2058165674","https://openalex.org/W2058723245","https://openalex.org/W2059806453","https://openalex.org/W2070637891","https://openalex.org/W2072691846","https://openalex.org/W2076787353","https://openalex.org/W2081469183","https://openalex.org/W2083633251","https://openalex.org/W2084550083","https://openalex.org/W2090271811","https://openalex.org/W2091775763","https://openalex.org/W2092343129","https://openalex.org/W2097567647","https://openalex.org/W2098546816","https://openalex.org/W2107728076","https://openalex.org/W2108288354","https://openalex.org/W2112933367","https://openalex.org/W2113456980","https://openalex.org/W2113539936","https://openalex.org/W2115361517","https://openalex.org/W2115403312","https://openalex.org/W2126800086","https://openalex.org/W2129678592","https://openalex.org/W2132508894","https://openalex.org/W2135508686","https://openalex.org/W2136250824","https://openalex.org/W2150712225","https://openalex.org/W2152410944","https://openalex.org/W2156220037","https://openalex.org/W2156941821","https://openalex.org/W2159671926","https://openalex.org/W2164067072","https://openalex.org/W2166086723","https://openalex.org/W2170724596","https://openalex.org/W2171405125","https://openalex.org/W2171444309","https://openalex.org/W2331442217","https://openalex.org/W2347366171","https://openalex.org/W2411477302","https://openalex.org/W2511246053","https://openalex.org/W4210821588","https://openalex.org/W4231712045","https://openalex.org/W4236328779","https://openalex.org/W4236879419","https://openalex.org/W4237709179","https://openalex.org/W4251377087","https://openalex.org/W4285719527","https://openalex.org/W4291919895","https://openalex.org/W4323284467"],"related_works":["https://openalex.org/W2064640561","https://openalex.org/W199744283","https://openalex.org/W2065994295","https://openalex.org/W2079863304","https://openalex.org/W2093732841","https://openalex.org/W2135441011","https://openalex.org/W150418346","https://openalex.org/W2460247932","https://openalex.org/W2077748849","https://openalex.org/W1858258953"],"abstract_inverted_index":{"Given":[0],"the":[1,8,15,22,31,45,49,53],"clear":[2],"role":[3],"of":[4,10,17,34,44,48,56,75,90],"genetic":[5,24,37,46,57,71,86],"factors":[6],"in":[7,21,93],"development":[9],"Alzheimer\u2019s":[11],"disease":[12],"(AD),":[13],"and":[14,85],"identification":[16],"several":[18],"genes":[19],"involved":[20],"disease,":[23,50],"testing":[25,60,72,87],"presents":[26],"some":[27],"interesting":[28],"possibilities":[29],"for":[30,39,61,73,88],"early":[32,62],"diagnosis":[33,63,74],"AD.":[35],"However,":[36],"tests":[38],"AD":[40,91],"are":[41],"complicated":[42,66],"because":[43,67],"complexity":[47],"which":[51],"limits":[52],"predictive":[54],"value":[55],"tests.":[58],"Genetic":[59],"is":[64],"further":[65],"it":[68],"lies":[69],"between":[70],"patients":[76],"who":[77],"clearly":[78],"have":[79],"a":[80],"dementia":[81],"consistent":[82],"with":[83],"AD,":[84],"prediction":[89],"onset":[92],"currently":[94],"asymptomatic":[95],"individuals.":[96]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
