{"id":"https://openalex.org/W59129145","doi":"https://doi.org/10.1152/ajpheart.2001.281.5.h1992","title":"Platelet-conditioned medium increases endothelial electrical resistance independently of cAMP/PKA and cGMP/PKG","display_name":"Platelet-conditioned medium increases endothelial electrical resistance independently of cAMP/PKA and cGMP/PKG","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W59129145","doi":"https://doi.org/10.1152/ajpheart.2001.281.5.h1992","mag":"59129145","pmid":"https://pubmed.ncbi.nlm.nih.gov/11668060"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.2001.281.5.h1992","doi":"https://doi.org/10.1152/ajpheart.2001.281.5.h1992","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.2001.281.5.h1992","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071250418","display_name":"Jonathan P. Gainor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan P. Gainor","raw_affiliation_strings":["Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046398770","display_name":"Christine A. Morton","orcid":"https://orcid.org/0000-0003-3008-8579","observed_orcids":["https://orcid.org/0000-0003-3008-8579"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine A. Morton","raw_affiliation_strings":["Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070594287","display_name":"Jared T. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared T. Roberts","raw_affiliation_strings":["Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025867170","display_name":"Peter A. Vincent","orcid":"https://orcid.org/0000-0002-2641-1874","observed_orcids":["https://orcid.org/0000-0002-2641-1874"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. Vincent","raw_affiliation_strings":["Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052846902","display_name":"Fred L. Minnear","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred L. Minnear","raw_affiliation_strings":["Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208-3479","institution_ids":["https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405260259"],"apc_list":null,"apc_paid":null,"fwci":0.5819,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.61748366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"281","issue":"5","first_page":"H1992","last_page":"H2001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.19629999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.9459999799728394},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6830000281333923},{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":0.8610000014305115},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.878000020980835},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.6729999780654907},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.7120000123977661},{"id":"https://openalex.org/keywords/pulmonary-artery-endothelium","display_name":"pulmonary artery endothelium","score":0.7049999833106995},{"id":"https://openalex.org/keywords/microvascular-endothelium","display_name":"microvascular endothelium","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.8769758939743042},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6290872693061829},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.5944201946258545},{"id":"https://openalex.org/C199217515","wikidata":"https://www.wikidata.org/wiki/Q24720987","display_name":"cGMP-dependent protein kinase","level":5,"score":0.5800150036811829},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5609120726585388},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5113748908042908},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5064629316329956},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4891098141670227},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.44533708691596985},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.43211114406585693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42879718542099},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42302176356315613},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3500722050666809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34116482734680176},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.30389541387557983}],"mesh":[{"descriptor_ui":"D000077191","descriptor_name":"Wortmannin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017869","descriptor_name":"Cyclic GMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019206","descriptor_name":"GTP-Binding Protein alpha Subunits, Gi-Go","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpheart.2001.281.5.h1992","doi":"https://doi.org/10.1152/ajpheart.2001.281.5.h1992","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.2001.281.5.h1992","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:11668060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11668060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.857.7422","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.857.7422","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpheart.physiology.org/content/ajpheart/281/5/H1992.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W112886495","https://openalex.org/W176987746","https://openalex.org/W194037863","https://openalex.org/W1890556425","https://openalex.org/W1968422435","https://openalex.org/W1971771344","https://openalex.org/W1973054747","https://openalex.org/W2009387204","https://openalex.org/W2010568321","https://openalex.org/W2014211428","https://openalex.org/W2020845461","https://openalex.org/W2036464893","https://openalex.org/W2038349428","https://openalex.org/W2043112660","https://openalex.org/W2049759529","https://openalex.org/W2050944466","https://openalex.org/W2051806653","https://openalex.org/W2053122488","https://openalex.org/W2060485911","https://openalex.org/W2068775635","https://openalex.org/W2100549520","https://openalex.org/W2100837269","https://openalex.org/W2103294240","https://openalex.org/W2117594247","https://openalex.org/W2124510663","https://openalex.org/W2136860362","https://openalex.org/W2150592919","https://openalex.org/W2151272706","https://openalex.org/W2152907506","https://openalex.org/W2166538320","https://openalex.org/W2177264898","https://openalex.org/W2200276621","https://openalex.org/W2221879822","https://openalex.org/W2339005914","https://openalex.org/W2397240651","https://openalex.org/W2408376652","https://openalex.org/W2415703952","https://openalex.org/W2417146222","https://openalex.org/W2433200533","https://openalex.org/W2469947486"],"related_works":["https://openalex.org/W2337773763","https://openalex.org/W2005502844","https://openalex.org/W2157699210","https://openalex.org/W2021533601","https://openalex.org/W1970539529","https://openalex.org/W3174394116","https://openalex.org/W2142176880","https://openalex.org/W2054017727","https://openalex.org/W2152846761","https://openalex.org/W2021087951"],"abstract_inverted_index":{"Platelets":[0],"release":[1],"a":[2,57,140,208,222],"soluble":[3],"factor":[4],"into":[5],"blood":[6],"and":[7,54,66,80,110,125,137,169,186,190,216,231],"conditioned":[8],"medium":[9],"(PCM)":[10],"that":[11,27,71,199],"decreases":[12],"vascular":[13],"endothelial":[14,92,202],"permeability.":[15,32],"The":[16],"objective":[17],"of":[18,35,43,74,78,85,108,119,126,156,158,176,188,214],"this":[19,29,106],"study":[20],"was":[21,37],"to":[22,102,113,142,182],"determine":[23],"the":[24,40,72,89,115,120,127,146,163,174,183,228],"signal-transduction":[25],"pathway":[26,212,224],"elicits":[28],"decrease":[30],"in":[31,91,145,149,205],"Permeability-decreasing":[33],"activity":[34,73,107,175],"PCM":[36,75,109,200,219],"assessed":[38],"by":[39,153],"real-time":[41],"measurement":[42],"electrical":[44,93,150,203],"resistance":[45,151,204],"across":[46],"cell":[47],"monolayers":[48],"derived":[49],"from":[50],"bovine":[51],"pulmonary":[52],"arteries":[53],"microvessels.":[55],"Using":[56],"desensitization":[58],"protocol":[59],"with":[60,162,180],"cAMP/protein":[61],"kinase":[62,161,165,166],"A":[63],"(PKA)-enhancing":[64],"agents":[65],"pharmacological":[67],"inhibitors,":[68],"we":[69],"determined":[70],"is":[76,111],"independent":[77,213],"PKA":[79],"PKG.":[81],"Genistein,":[82],"an":[83],"inhibitor":[84],"tyrosine":[86,226],"kinases,":[87],"prevented":[88],"increase":[90],"resistance.":[94],"Because":[95],"lysophosphatidic":[96],"acid":[97],"(LPA)":[98],"has":[99],"been":[100],"proposed":[101],"be":[103],"responsible":[104],"for":[105,194],"known":[112],"activate":[114],"G(i)":[116,189,229],"protein,":[117,230],"inhibitors":[118,167],"G":[121],"protein":[122],"pertussis":[123],"toxin":[124,136],"associated":[128],"phosphatidylinositol":[129],"3-kinase":[130],"(PI3K)":[131],"wortmannin":[132,138],"were":[133,192],"used.":[134],"Pertussis":[135],"caused":[139],"10-":[141],"15-min":[143],"delay":[144],"characteristic":[147],"rise":[148],"induced":[152],"PCM.":[154,177],"Inhibition":[155],"phosphorylation":[157],"extracellular":[159],"signal-regulated":[160],"mitogen-activated":[164],"PD-98059":[168],"U-0126":[170],"did":[171],"not":[172],"prevent":[173],"Similar":[178],"findings":[179],"regard":[181],"cAMP":[184],"protocols":[185],"inhibition":[187],"PI3K":[191],"obtained":[193],"1-oleoyl-LPA.":[195],"These":[196],"results":[197],"demonstrate":[198],"increases":[201],"vitro":[206],"via":[207],"novel,":[209],"signal":[210],"transduction":[211],"cAMP/PKA":[215],"cGMP/PKG.":[217],"Furthermore,":[218],"rapidly":[220],"activates":[221],"signaling":[223],"involving":[225],"phosphorylation,":[227],"PI3K.":[232]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}