{"id":"https://openalex.org/W588955453","doi":null,"title":"Efficacy and safety of prenatal allopurinol treatment in low birth weight piglets with special emphasis on learning ability","display_name":"Efficacy and safety of prenatal allopurinol treatment in low birth weight piglets with special emphasis on learning ability","publication_year":2013,"publication_date":"2013-01-15","ids":{"openalex":"https://openalex.org/W588955453","mag":"588955453"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/260874","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/260874","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.library.uu.nl:8080/handle/1874/260874","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002993437","display_name":"Alexandra Antonides","orcid":"https://orcid.org/0009-0007-5278-0482","observed_orcids":["https://orcid.org/0009-0007-5278-0482"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexandra Antonides","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-5278-0482","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002993437"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.8672000169754028,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.8672000169754028,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/low-birth-weight","display_name":"low birth weight","score":0.9819999933242798},{"id":"https://openalex.org/keywords/fetal-asphyxia","display_name":"fetal asphyxia","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7870000004768372},{"id":"https://openalex.org/keywords/learning-ability","display_name":"learning ability","score":0.609000027179718},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7310000061988831},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.7820000052452087},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.8302563428878784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.545936107635498},{"id":"https://openalex.org/C2779083892","wikidata":"https://www.wikidata.org/wiki/Q6692979","display_name":"Low birth weight","level":3,"score":0.5185064077377319},{"id":"https://openalex.org/C177454536","wikidata":"https://www.wikidata.org/wiki/Q578290","display_name":"Emphasis (telecommunications)","level":2,"score":0.5179266333580017},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.36040109395980835},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.23707279562950134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23676982522010803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22123584151268005},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19535967707633972},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09455627202987671},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/260874","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/260874","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:588955453","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/260874","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/260874","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/260874","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W95638346","https://openalex.org/W613458142","https://openalex.org/W1548015133","https://openalex.org/W1775657207","https://openalex.org/W1964209509","https://openalex.org/W1965021256","https://openalex.org/W1972136516","https://openalex.org/W1975616485","https://openalex.org/W1978471986","https://openalex.org/W1985249496","https://openalex.org/W1985759738","https://openalex.org/W1986981418","https://openalex.org/W1994959545","https://openalex.org/W2002269747","https://openalex.org/W2005607003","https://openalex.org/W2018634285","https://openalex.org/W2019766973","https://openalex.org/W2022059371","https://openalex.org/W2025653580","https://openalex.org/W2036980124","https://openalex.org/W2041129027","https://openalex.org/W2050917786","https://openalex.org/W2053808137","https://openalex.org/W2055254460","https://openalex.org/W2062803021","https://openalex.org/W2064333311","https://openalex.org/W2066051611","https://openalex.org/W2071197145","https://openalex.org/W2073924899","https://openalex.org/W2074591351","https://openalex.org/W2075618588","https://openalex.org/W2082501904","https://openalex.org/W2087549799","https://openalex.org/W2088432899","https://openalex.org/W2090369139","https://openalex.org/W2090673332","https://openalex.org/W2092857303","https://openalex.org/W2094524870","https://openalex.org/W2094978599","https://openalex.org/W2097744068","https://openalex.org/W2099137874","https://openalex.org/W2103490208","https://openalex.org/W2105213855","https://openalex.org/W2105863262","https://openalex.org/W2109756862","https://openalex.org/W2111833097","https://openalex.org/W2115863844","https://openalex.org/W2118435678","https://openalex.org/W2135080739","https://openalex.org/W2137390932","https://openalex.org/W2143350631","https://openalex.org/W2143443369","https://openalex.org/W2150858502","https://openalex.org/W2153821084","https://openalex.org/W2164325598","https://openalex.org/W2166248226","https://openalex.org/W2168795031","https://openalex.org/W2410617681","https://openalex.org/W2418281073","https://openalex.org/W2495580951"],"related_works":["https://openalex.org/W1971329754","https://openalex.org/W2040278236","https://openalex.org/W7099118825","https://openalex.org/W7094484358","https://openalex.org/W2888134672","https://openalex.org/W2109756862","https://openalex.org/W2042001922","https://openalex.org/W2183614785","https://openalex.org/W2330284095","https://openalex.org/W2052317865"],"abstract_inverted_index":{"Allopurinol":[0],"is":[1,5,150,244],"a":[2,9,162],"medicine":[3],"which":[4],"currently":[6],"studied":[7],"in":[8,12,209,228],"clinical":[10],"trial":[11],"humans":[13],"to":[14,246],"possibly":[15],"prevent":[16],"brain":[17,34],"damage":[18,35],"caused":[19,160],"by":[20,36,161],"acute":[21,44],"shortage":[22,163],"of":[23,40,62,84,95,108,164],"oxygen":[24],"around":[25],"birth.":[26],"Earlier":[27],"studies":[28],"showed":[29],"that":[30,152,171,218,236],"allopurinol":[31,85,103,237],"can":[32],"limit":[33],"reducing":[37],"the":[38,54,70,81,105,173,187,210],"formation":[39],"free":[41],"radicals":[42],"after":[43,58],"asphyxia/hypoxia.":[45],"However,":[46],"no":[47],"research":[48,243],"has":[49],"yet":[50],"been":[51],"conducted":[52],"on":[53,86],"long-term":[55,82],"cognitive":[56,132,188],"effects":[57,83,94],"chronic,":[59],"prenatal":[60],"treatment":[61],"prolonged":[63],"but":[64,199],"mild":[65,167],"asphyxia":[66,168],"during":[67,104],"pregnancy.":[68,109],"In":[69,88],"present":[71],"study,":[72],"pigs":[73],"were":[74,100,121,129,145,226],"used":[75],"as":[76,114],"model":[77],"species":[78],"for":[79],"studying":[80],"cognition.":[87],"addition,":[89],"we":[90],"investigated":[91],"possible":[92],"side":[93],"this":[96],"treatment.":[97],"Six":[98,110],"sows":[99,112],"treated":[101],"with":[102,135],"last":[106],"trimester":[107],"untreated":[111],"served":[113],"controls.":[115],"After":[116],"birth,":[117],"piglets":[118,134,206],"and":[119,123,140,181,195],"placentas":[120],"measured,":[122],"umbilical":[124],"cord":[125],"mixed":[126],"blood":[127],"samples":[128],"taken.":[130],"For":[131],"tests,":[133],"normal":[136],"birth":[137,142,154],"weight":[138,143,155],"(NBW)":[139],"low":[141,153],"(LBW)":[144],"selected":[146],"per":[147],"sow.":[148],"It":[149],"believed":[151],"reflects":[156],"intra-uterine":[157],"growth":[158],"restriction,":[159],"oxygen,":[165],"i.e.":[166],"and/or":[169],"nutrients":[170],"reach":[172],"fetus.":[174],"An":[175],"Open":[176,211],"Field":[177,212],"test":[178,213],"was":[179,184],"conducted,":[180],"learning":[182,240],"ability":[183],"assessed":[185],"using":[186],"Holeboard":[189,229],"task.":[190],"Treatment":[191],"reduced":[192],"placenta":[193],"length":[194],"increased":[196],"piglet":[197],"length,":[198],"did":[200],"not":[201],"affect":[202],"other":[203],"measures.":[204],"LBW":[205],"vocalized":[207],"more":[208,221],"than":[214],"NBW":[215],"piglets,":[216],"suggesting":[217],"they":[219],"are":[220,234],"easily":[222],"stressed.":[223],"No":[224],"differences":[225],"found":[227],"task":[230],"performance,":[231],"although":[232],"there":[233],"indications":[235],"might":[238],"reduce":[239],"ability.":[241],"Further":[242],"needed":[245],"elucidate":[247],"these":[248],"indications.":[249]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}