{"id":"https://openalex.org/W58808350","doi":null,"title":"Novel Directions In Therapy Against Age-Related Vascular Disease","display_name":"Novel Directions In Therapy Against Age-Related Vascular Disease","publication_year":2014,"publication_date":"2014-09-25","ids":{"openalex":"https://openalex.org/W58808350","mag":"58808350"},"language":"en","primary_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/a41ac399-f572-479d-9b96-f763be95cf6b","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/a41ac399-f572-479d-9b96-f763be95cf6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.eur.nl/en/publications/a41ac399-f572-479d-9b96-f763be95cf6b","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Haiyan Wu","orcid":"https://orcid.org/0000-0003-2550-0290","observed_orcids":["https://orcid.org/0000-0003-2550-0290"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Haiyan Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2550-0290","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.5913000106811523,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.10719999670982361,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.10429999977350235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.890999972820282},{"id":"https://openalex.org/keywords/vascular-aging","display_name":"vascular aging","score":0.8389999866485596},{"id":"https://openalex.org/keywords/age-related-vascular-disease","display_name":"age-related vascular disease","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hutchinson-gilford-progeria-syndrome","display_name":"Hutchinson-Gilford progeria syndrome","score":0.890999972820282},{"id":"https://openalex.org/keywords/progeroid-syndromes","display_name":"progeroid syndromes","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.7429999709129333},{"id":"https://openalex.org/keywords/mitochondrial-damage","display_name":"mitochondrial damage","score":0.9190000295639038},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2778465436","wikidata":"https://www.wikidata.org/wiki/Q213098","display_name":"Progeria","level":3,"score":0.9189214110374451},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.867378830909729},{"id":"https://openalex.org/C2778090637","wikidata":"https://www.wikidata.org/wiki/Q1154619","display_name":"Werner syndrome","level":5,"score":0.7731641530990601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6217575669288635},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.5930256843566895},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5887443423271179},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.50539231300354},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4925702214241028},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4761250615119934},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.47315916419029236},{"id":"https://openalex.org/C2779371275","wikidata":"https://www.wikidata.org/wiki/Q914389","display_name":"Cockayne syndrome","level":5,"score":0.47123679518699646},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4487796425819397},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35567766427993774},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.2558889389038086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23921480774879456},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.20281296968460083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18094372749328613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13321909308433533},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:eur:oai:pure.eur.nl:publications/a41ac399-f572-479d-9b96-f763be95cf6b","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/a41ac399-f572-479d-9b96-f763be95cf6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:76105","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/76105","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:repub.eur.nl:76105","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/76105","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:58808350","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/76105/140825_Wu-Haiyan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/a41ac399-f572-479d-9b96-f763be95cf6b","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/a41ac399-f572-479d-9b96-f763be95cf6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1550905784","https://openalex.org/W1974190070","https://openalex.org/W1982602899","https://openalex.org/W1987728005","https://openalex.org/W1990461933","https://openalex.org/W1993426999","https://openalex.org/W2000841566","https://openalex.org/W2010466875","https://openalex.org/W2018211784","https://openalex.org/W2025750116","https://openalex.org/W2027272551","https://openalex.org/W2034137026","https://openalex.org/W2034366812","https://openalex.org/W2035904563","https://openalex.org/W2044406058","https://openalex.org/W2045619262","https://openalex.org/W2047136642","https://openalex.org/W2050178809","https://openalex.org/W2056354555","https://openalex.org/W2057075176","https://openalex.org/W2081572906","https://openalex.org/W2085525271","https://openalex.org/W2088501994","https://openalex.org/W2101214961","https://openalex.org/W2108433881","https://openalex.org/W2110930701","https://openalex.org/W2112365416","https://openalex.org/W2114171855","https://openalex.org/W2114423489","https://openalex.org/W2117583063","https://openalex.org/W2122400411","https://openalex.org/W2127905773","https://openalex.org/W2134046854","https://openalex.org/W2134899427","https://openalex.org/W2136482074","https://openalex.org/W2142920603","https://openalex.org/W2144937091","https://openalex.org/W2145200068","https://openalex.org/W2152362788","https://openalex.org/W2153176907","https://openalex.org/W2153316977","https://openalex.org/W2157043260","https://openalex.org/W2159781994","https://openalex.org/W2165966968","https://openalex.org/W2284471912","https://openalex.org/W3015544325"],"related_works":["https://openalex.org/W1987728005","https://openalex.org/W2034366812","https://openalex.org/W2407440457","https://openalex.org/W2017567442","https://openalex.org/W1984289509","https://openalex.org/W4387773736","https://openalex.org/W2891919070","https://openalex.org/W3185216081","https://openalex.org/W2011921507","https://openalex.org/W2768125432"],"abstract_inverted_index":{"__Abstract__":[0],"\\n":[1],"\\nGenomic":[2],"instability":[3,50],"is":[4,55],"recognized":[5],"as":[6,34,120],"one":[7],"of":[8,43,48,85,107],"the":[9,79,105,111,116],"primary":[10],"mechanisms":[11,102],"that":[12,87,103],"lead":[13],"to":[14,19,28,52,61,71],"organismal":[15],"\\naging,":[16],"and":[17,40,114,126,129,134],"leads":[18],"progeria":[20],"when":[21],"developing":[22],"in":[23,38,64,67,82,91],"an":[24],"accelerated":[25],"pace":[26],"due":[27],"defective":[29],"\\ngenomic":[30],"maintenance":[31],"systems,":[32],"such":[33,119],"nucleotide":[35,92],"excision":[36,93],"repair,":[37],"humans":[39],"mouse":[41,95],"\\nmodels":[42],"progeroid":[44],"syndromes.":[45],"The":[46],"role":[47,63],"genomic":[49,108],"related":[51],"nuclear":[53],"DNA":[54],"\\ncurrently":[56],"under":[57],"investigation":[58],"with":[59],"respect":[60],"its":[62],"cardiovascular":[65],"disease,":[66],"particular":[68],"\\nin":[69],"relation":[70],"vascular":[72,113],"aging.":[73],"In":[74],"this":[75,83],"review":[76],"we":[77],"highlight":[78],"first":[80],"findings":[81],"field":[84],"\\nresearch":[86],"come":[88],"from":[89,98],"experiment":[90],"repair-defective":[94],"models":[96],"\\nand":[97],"genetic":[99],"studies.":[100],"Possible":[101],"mediate":[104],"consequences":[106],"\\ninstability":[109],"at":[110,115],"local,":[112],"systemic":[117],"level,":[118],"cell":[121],"senescence,":[122],"mutations,":[123],"\\nmitochondrial":[124],"damage,":[125],"sirtuin":[127],"1":[128],"IGF-1":[130],"decrease,":[131],"are":[132,140],"discussed":[133],"important":[135],"goals":[136],"\\nfor":[137],"future":[138],"research":[139],"set.":[141]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}