{"id":"https://openalex.org/W587907907","doi":"https://doi.org/10.1016/j.actbio.2015.06.012","title":"A sustained intravitreal drug delivery system with remote real time monitoring capability","display_name":"A sustained intravitreal drug delivery system with remote real time monitoring capability","publication_year":2015,"publication_date":"2015-06-15","ids":{"openalex":"https://openalex.org/W587907907","doi":"https://doi.org/10.1016/j.actbio.2015.06.012","mag":"587907907","pmid":"https://pubmed.ncbi.nlm.nih.gov/26087110","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4560601"},"language":"en","primary_location":{"id":"doi:10.1016/j.actbio.2015.06.012","doi":"https://doi.org/10.1016/j.actbio.2015.06.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.actbio.2015.06.012","pdf_url":null,"source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4560601","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054251154","display_name":"Huiyuan Hou","orcid":"https://orcid.org/0000-0003-0082-8353","observed_orcids":["https://orcid.org/0000-0003-0082-8353"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiyuan Hou","raw_affiliation_strings":["Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036677445","display_name":"Alejandra Nieto","orcid":"https://orcid.org/0000-0003-0802-4800","observed_orcids":["https://orcid.org/0000-0003-0802-4800"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra Nieto","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, United States"],"raw_orcid":"https://orcid.org/0000-0003-0802-4800","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113950762","display_name":"Akram Belghith","orcid":"https://orcid.org/0000-0001-8837-0206","observed_orcids":["https://orcid.org/0000-0001-8837-0206"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akram Belghith","raw_affiliation_strings":["Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019898346","display_name":"Kaihui Nan","orcid":"https://orcid.org/0000-0002-6592-1682","observed_orcids":["https://orcid.org/0000-0002-6592-1682"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaihui Nan","raw_affiliation_strings":["Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032400855","display_name":"Yang Yang Li","orcid":"https://orcid.org/0000-0003-4153-9558","observed_orcids":["https://orcid.org/0000-0003-4153-9558","https://orcid.org/0009-0004-7403-5553"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yangyang Li","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101974691","display_name":"William R. Freeman","orcid":"https://orcid.org/0000-0001-9979-2500","observed_orcids":["https://orcid.org/0000-0001-9979-2500"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Freeman","raw_affiliation_strings":["Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059375688","display_name":"Michael J. Sailor","orcid":"https://orcid.org/0000-0002-4809-9826","observed_orcids":["https://orcid.org/0000-0002-4809-9826"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Sailor","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039407742","display_name":"Lingyun Cheng","orcid":"https://orcid.org/0000-0002-0748-5173","observed_orcids":["https://orcid.org/0000-0002-0748-5173"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lingyun Cheng","raw_affiliation_strings":["Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States. Electronic address: l1cheng@ucsd.edu","Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States. Electronic address: l1cheng@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Jacobs Retina Center/Shiley Eye Center at University of California, San Diego, United States","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039407742"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":1.5679,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.7762137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":null,"first_page":"309","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.7354000210762024,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.7354000210762024,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11169","display_name":"Silicon Nanostructures and Photoluminescence","score":0.1517000049352646,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravitreal-drug-delivery","display_name":"intravitreal drug delivery","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7990000247955322},{"id":"https://openalex.org/keywords/porous-silicon","display_name":"porous silicon","score":0.7919999957084656},{"id":"https://openalex.org/keywords/photonic-crystals","display_name":"photonic crystals","score":0.9459999799728394},{"id":"https://openalex.org/keywords/electrochemical-etching","display_name":"electrochemical etching","score":0.8009999990463257},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.7039999961853027},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":1.0},{"id":"https://openalex.org/keywords/chorioretinal-diseases","display_name":"chorioretinal diseases","score":0.8999999761581421},{"id":"https://openalex.org/keywords/vitreous-drug-concentration","display_name":"vitreous drug concentration","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6850196719169617},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6710835695266724},{"id":"https://openalex.org/C2776685891","wikidata":"https://www.wikidata.org/wiki/Q428660","display_name":"Porous silicon","level":3,"score":0.620864987373352},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4458664655685425},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4432542026042938},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4032760560512543},{"id":"https://openalex.org/C544956773","wikidata":"https://www.wikidata.org/wiki/Q670","display_name":"Silicon","level":2,"score":0.36586636304855347},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.28000015020370483},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2201405167579651},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1850525438785553}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014741","descriptor_name":"Video Recording","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.actbio.2015.06.012","doi":"https://doi.org/10.1016/j.actbio.2015.06.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.actbio.2015.06.012","pdf_url":null,"source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},{"id":"pmid:26087110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26087110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta biomaterialia","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3981380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4560601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4560601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4560601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acta Biomater","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0hm737pd","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0hm737pd","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Biomaterialia, vol 24","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3981380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4560601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4217451883","display_name":null,"funder_award_id":"EY 020617","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G692105573","display_name":"Porous Silicon Particles for Sustained Intravitreal Drug Delivery","funder_award_id":"R01EY020617","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000910452","display_name":"NEI Center Core Grant for Vision Research","funder_award_id":"P30EY022589","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W818694610","https://openalex.org/W1481978003","https://openalex.org/W1498783670","https://openalex.org/W1500728559","https://openalex.org/W1968189763","https://openalex.org/W1969202298","https://openalex.org/W1975606985","https://openalex.org/W1990217049","https://openalex.org/W1996466297","https://openalex.org/W2000681367","https://openalex.org/W2005272995","https://openalex.org/W2005484249","https://openalex.org/W2006898897","https://openalex.org/W2011630968","https://openalex.org/W2012976282","https://openalex.org/W2014007498","https://openalex.org/W2017700229","https://openalex.org/W2022115052","https://openalex.org/W2026286790","https://openalex.org/W2026524260","https://openalex.org/W2032934982","https://openalex.org/W2037831461","https://openalex.org/W2043385591","https://openalex.org/W2046358777","https://openalex.org/W2057036168","https://openalex.org/W2066424161","https://openalex.org/W2068285545","https://openalex.org/W2074845742","https://openalex.org/W2078588592","https://openalex.org/W2081535879","https://openalex.org/W2082066892","https://openalex.org/W2085779737","https://openalex.org/W2087415039","https://openalex.org/W2087593396","https://openalex.org/W2093620952","https://openalex.org/W2095427264","https://openalex.org/W2131129776","https://openalex.org/W2148230234","https://openalex.org/W2158699314","https://openalex.org/W2188739101","https://openalex.org/W2269439020","https://openalex.org/W4231296216"],"related_works":["https://openalex.org/W1975606985","https://openalex.org/W2057036168","https://openalex.org/W2280794878","https://openalex.org/W2066424161","https://openalex.org/W2869759688","https://openalex.org/W818694610","https://openalex.org/W122984612","https://openalex.org/W3212011949","https://openalex.org/W2074845742","https://openalex.org/W1996466297"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}