{"id":"https://openalex.org/W58787318","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb447","title":"Berry anthocyanin fractions inhibit LPS\u2010induced expression of inflammatory mediators in RAW 264.7 macrophages","display_name":"Berry anthocyanin fractions inhibit LPS\u2010induced expression of inflammatory mediators in RAW 264.7 macrophages","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W58787318","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb447","mag":"58787318"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.lb447","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb447","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.lb447","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028060131","display_name":"Sang Gil Lee","orcid":"https://orcid.org/0000-0001-8127-8132","observed_orcids":["https://orcid.org/0000-0001-8127-8132"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang Gil Lee","raw_affiliation_strings":["Nutritional Sciences University of Connecticut Storrs CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences University of Connecticut Storrs CT","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002218759","display_name":"Young\u2010Ki Park","orcid":"https://orcid.org/0000-0003-3503-5847","observed_orcids":["https://orcid.org/0000-0003-3503-5847"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young-ki Park","raw_affiliation_strings":["Nutritional Sciences University of Connecticut Storrs CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences University of Connecticut Storrs CT","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447458","display_name":"Ji\u2010Young Lee","orcid":"https://orcid.org/0000-0002-7945-793X","observed_orcids":["https://orcid.org/0000-0002-7945-793X"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyoung Lee","raw_affiliation_strings":["Nutritional Sciences University of Connecticut Storrs CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences University of Connecticut Storrs CT","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109012011","display_name":"Sung I. Koo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung I. Koo","raw_affiliation_strings":["Nutritional Sciences University of Connecticut Storrs CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences University of Connecticut Storrs CT","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074418042","display_name":"Ock K. Chun","orcid":"https://orcid.org/0000-0002-7391-2380","observed_orcids":["https://orcid.org/0000-0002-7391-2380"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ock K. Chun","raw_affiliation_strings":["Nutritional Sciences University of Connecticut Storrs CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences University of Connecticut Storrs CT","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00686765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.843999981880188},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.968999981880188},{"id":"https://openalex.org/keywords/blackberry","display_name":"blackberry","score":0.6269999742507935},{"id":"https://openalex.org/keywords/blueberry","display_name":"blueberry","score":0.996999979019165},{"id":"https://openalex.org/keywords/black-currant","display_name":"black currant","score":0.9990000128746033},{"id":"https://openalex.org/keywords/malvidin","display_name":"malvidin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cyanidin","display_name":"cyanidin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/delphinidin","display_name":"delphinidin","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anthocyanin-composition","display_name":"anthocyanin composition","score":0.8610000014305115},{"id":"https://openalex.org/keywords/solid-phase-extraction","display_name":"solid-phase extraction","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2778945092","wikidata":"https://www.wikidata.org/wiki/Q262547","display_name":"Anthocyanin","level":2,"score":0.9234192371368408},{"id":"https://openalex.org/C2776034682","wikidata":"https://www.wikidata.org/wiki/Q13184","display_name":"Berry","level":2,"score":0.880615234375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.677169919013977},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6312214136123657},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6290714740753174},{"id":"https://openalex.org/C2780949515","wikidata":"https://www.wikidata.org/wiki/Q137220","display_name":"Malvidin","level":4,"score":0.5960394144058228},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.5509063005447388},{"id":"https://openalex.org/C2781021748","wikidata":"https://www.wikidata.org/wiki/Q367258","display_name":"Delphinidin","level":4,"score":0.4401562213897705},{"id":"https://openalex.org/C64584667","wikidata":"https://www.wikidata.org/wiki/Q161179","display_name":"Pigment","level":2,"score":0.41895946860313416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36645910143852234},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3647075295448303},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3446230888366699},{"id":"https://openalex.org/C2777667348","wikidata":"https://www.wikidata.org/wiki/Q417606","display_name":"Cyanidin","level":3,"score":0.3211755156517029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25087785720825195},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16951876878738403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11524942517280579},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.lb447","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb447","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.lb447","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2530703470","https://openalex.org/W2308391468","https://openalex.org/W2028570107","https://openalex.org/W2010881622","https://openalex.org/W2149117731","https://openalex.org/W115840955","https://openalex.org/W2902307039","https://openalex.org/W2039037793","https://openalex.org/W3202201921","https://openalex.org/W3013840293"],"abstract_inverted_index":{"Considerable":[0],"attention":[1],"has":[2],"been":[3],"directed":[4],"to":[5,20,55,156],"the":[6,21,57,139,187],"health":[7],"benefits":[8,16],"of":[9,26,60,63,82,127,166],"berries":[10,41,64,167],"in":[11,28,66,70,73,77],"preventing":[12],"chronic":[13],"diseases.":[14],"The":[15,147,160],"are":[17],"mainly":[18],"attributed":[19],"antioxidant":[22,35],"and":[23,49,75,85,107,124,129,154,174,189],"anti\u2010inflammatory":[24,58,164,184],"properties":[25],"anthocyanins":[27,32,68],"berries.":[29],"Since":[30],"individual":[31],"have":[33],"different":[34,43,47],"properties,":[36],"it":[37],"is":[38],"probable":[39],"that":[40,163,175],"having":[42],"anthocyanin":[44,172,177],"compositions":[45,173],"exert":[46],"biological":[48],"physiological":[50],"effects.":[51],"This":[52],"study":[53],"aimed":[54],"compare":[56],"effects":[59,165],"three":[61],"types":[62],"differing":[65],"major":[67],"(malvidin":[69],"blueberry,":[71,83],"cyanidin":[72],"blackberry,":[74],"delphinidin":[76],"blackcurrant,":[78],"respectively).":[79],"Anthocyanin":[80],"fractions":[81,150],"blackberry":[84,176],"blackcurrant":[86,190],"were":[87,102,117],"obtained":[88],"by":[89,133,142],"solid":[90],"phase":[91],"extraction":[92],"from":[93],"80":[94],"%":[95],"methanol":[96],"crude":[97],"extracts.":[98],"RAW":[99],"264.7":[100],"macrophages":[101],"treated":[103,118],"with":[104,119],"5,":[105],"10,":[106],"25":[108,145],"ug/mL":[109],"berry":[110,149],"extracts":[111],"for":[112,121],"12":[113,122],"h.":[114],"Then,":[115],"cells":[116],"LPS":[120],"h":[123],"mRNA":[125],"abundance":[126],"TNF\u2010alpha":[128,153],"IL\u20101beta":[130],"was":[131],"determined":[132],"real\u2010time":[134],"PCR.":[135],"Blackberry":[136],"fraction":[137,178],"suppressed":[138,152],"gene":[140],"expression":[141],"15\u201320%":[143],"at":[144],"ug/mL.":[146],"other":[148],"also":[151],"IL1\u2010beta":[155],"a":[157,181],"lesser":[158],"extent.":[159],"findings":[161],"suggest":[162],"vary":[168],"depending":[169],"on":[170],"their":[171],"may":[179],"possess":[180],"more":[182],"potent":[183],"property":[185],"than":[186],"blueberry":[188],"fractions.":[191]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}