{"id":"https://openalex.org/W58756698","doi":null,"title":"Quantitative model for multiple levels of drug resistance in clinical tumors.","display_name":"Quantitative model for multiple levels of drug resistance in clinical tumors.","publication_year":1983,"publication_date":"1983-10-01","ids":{"openalex":"https://openalex.org/W58756698","mag":"58756698","pmid":"https://pubmed.ncbi.nlm.nih.gov/6627236"},"language":"en","primary_location":{"id":"pmid:6627236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6627236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036266304","display_name":"J.H. Goldie","orcid":"https://orcid.org/0000-0001-9828-8468","observed_orcids":["https://orcid.org/0000-0001-9828-8468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Goldie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040731269","display_name":"Andrew J. Coldman","orcid":"https://orcid.org/0000-0002-3263-2649","observed_orcids":["https://orcid.org/0000-0002-3263-2649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Coldman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.2273,"has_fulltext":false,"cited_by_count":189,"citation_normalized_percentile":{"value":0.99052133,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"67","issue":"10","first_page":"923","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.41920000314712524,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/phenotypic-heterogeneity","display_name":"phenotypic heterogeneity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.5009999871253967},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"mutation rate","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.771196722984314},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6661049127578735},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6295363903045654},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6019526124000549},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5812169313430786},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4248749613761902},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.41793137788772583},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41384032368659973},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3625607192516327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3131791055202484},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2939346432685852},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2669617235660553},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19198444485664368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18615314364433289},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6627236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6627236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Journal Article"},{"id":"mag:58756698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6627236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022562134","https://openalex.org/W146977150","https://openalex.org/W2764308330","https://openalex.org/W2009031936","https://openalex.org/W2502480703","https://openalex.org/W2611714775","https://openalex.org/W942243915","https://openalex.org/W2336875093","https://openalex.org/W2762933103","https://openalex.org/W4237681424"],"abstract_inverted_index":{"A":[0],"mathematical":[1],"model":[2,96],"to":[3,21,79,144],"examine":[4],"the":[5,22,100,119,122,125,134,137,160,166],"effect":[6],"of":[7,24,37,50,64,67,82,91,103,124,136,162,165],"cellular":[8],"differentiation":[9],"on":[10,117],"phenotypic":[11,101],"drug":[12,68,163],"resistance":[13,69],"in":[14,34,56,133,159],"neoplasms":[15],"is":[16,19,60],"proposed.":[17],"Attention":[18],"restricted":[20],"maintenance":[23],"stem":[25,38,52,88],"cell":[26,39,89],"proliferative":[27],"capacity.":[28],"For":[29],"fixed":[30],"mutation":[31],"rates,":[32],"tumors":[33,85,107],"which":[35,57,77],"loss":[36,59],"capacity":[40],"occurs":[41],"with":[42,86],"high":[43],"frequency":[44],"will":[45,70,108,128],"have":[46],"a":[47,73,87,92,130],"higher":[48],"proportion":[49],"resistant":[51],"cells":[53],"than":[54],"those":[55],"such":[58],"infrequent.":[61],"The":[62],"acquisition":[63],"multiple":[65],"levels":[66],"proceed":[71],"at":[72,151],"disproportionately":[74],"accelerated":[75],"pace,":[76],"leads":[78],"greater":[80],"degrees":[81],"incurability":[83],"for":[84,149],"compartment":[90],"given":[93],"size.":[94],"This":[95,147],"directly":[97],"predicts":[98],"that":[99],"heterogeneity":[102,115],"slow-growing":[104],"advanced":[105,167],"clinical":[106],"be":[109,129,142,157],"very":[110],"great.":[111],"However,":[112],"as":[113],"this":[114],"depends":[116],"both":[118],"size":[120],"and":[121],"age":[123],"tumor,":[126],"there":[127],"period":[131],"early":[132,153],"development":[135],"tumor":[138],"when":[139],"it":[140],"should":[141],"susceptible":[143],"drug-induced":[145],"cure.":[146],"potential":[148],"curability":[150],"an":[152],"stage":[154],"may":[155],"not":[156],"reflected":[158],"pattern":[161],"responsiveness":[164],"tumor.":[168]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}