{"id":"https://openalex.org/W587528119","doi":null,"title":"La fonction contractile r\u00e9gionale du myocarde post-isch\u00e9mique : adaptations physiopathologiques et pharmacologiques","display_name":"La fonction contractile r\u00e9gionale du myocarde post-isch\u00e9mique : adaptations physiopathologiques et pharmacologiques","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W587528119","mag":"587528119"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/788943","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/788943","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040461172","display_name":"Laurence Lucats","orcid":"https://orcid.org/0000-0002-4735-0951","observed_orcids":["https://orcid.org/0000-0002-4735-0951"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laurence Lucats","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4735-0951","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040461172"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regional-myocardial-contractility","display_name":"regional myocardial contractility","score":0.8610000014305115},{"id":"https://openalex.org/keywords/myocardial-stunning","display_name":"myocardial stunning","score":0.7770000100135803},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.7609999775886536},{"id":"https://openalex.org/keywords/late-preconditioning","display_name":"late preconditioning","score":0.5659999847412109},{"id":"https://openalex.org/keywords/ivabradine","display_name":"ivabradine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ventricular-asynchrony","display_name":"ventricular asynchrony","score":0.847000002861023},{"id":"https://openalex.org/keywords/systolic-thickening","display_name":"systolic thickening","score":0.7009999752044678},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/fkbp12-6","display_name":"FKBP12.6","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.847000002861023},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6742987036705017},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3922104239463806}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/788943","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/788943","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:587528119","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2006PA120048","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":260,"referenced_works":["https://openalex.org/W20162488","https://openalex.org/W44430016","https://openalex.org/W60892343","https://openalex.org/W118182295","https://openalex.org/W158335811","https://openalex.org/W194457679","https://openalex.org/W1269302828","https://openalex.org/W1510710257","https://openalex.org/W1598476292","https://openalex.org/W1628979938","https://openalex.org/W1683420538","https://openalex.org/W1768713563","https://openalex.org/W1814497677","https://openalex.org/W1838048421","https://openalex.org/W1856107376","https://openalex.org/W1932166311","https://openalex.org/W1964825054","https://openalex.org/W1966229422","https://openalex.org/W1966502113","https://openalex.org/W1967526945","https://openalex.org/W1968940913","https://openalex.org/W1970793487","https://openalex.org/W1971192897","https://openalex.org/W1971597120","https://openalex.org/W1972112252","https://openalex.org/W1972351278","https://openalex.org/W1973056685","https://openalex.org/W1973160550","https://openalex.org/W1974085555","https://openalex.org/W1975395211","https://openalex.org/W1975774325","https://openalex.org/W1975832543","https://openalex.org/W1977661035","https://openalex.org/W1978221784","https://openalex.org/W1979363597","https://openalex.org/W1979947635","https://openalex.org/W1980622321","https://openalex.org/W1981576632","https://openalex.org/W1982260690","https://openalex.org/W1983606561","https://openalex.org/W1983619570","https://openalex.org/W1983730633","https://openalex.org/W1986441073","https://openalex.org/W1986680773","https://openalex.org/W1987636927","https://openalex.org/W1987847419","https://openalex.org/W1988211761","https://openalex.org/W1988276642","https://openalex.org/W1988674701","https://openalex.org/W1989865205","https://openalex.org/W1991194822","https://openalex.org/W1994543305","https://openalex.org/W1994681182","https://openalex.org/W1994765179","https://openalex.org/W1996188899","https://openalex.org/W1996331100","https://openalex.org/W1998503563","https://openalex.org/W1999113917","https://openalex.org/W1999637274","https://openalex.org/W2000884462","https://openalex.org/W2002384956","https://openalex.org/W2002459835","https://openalex.org/W2002564316","https://openalex.org/W2003203834","https://openalex.org/W2005419514","https://openalex.org/W2005591501","https://openalex.org/W2006308176","https://openalex.org/W2006469962","https://openalex.org/W2006491962","https://openalex.org/W2006588307","https://openalex.org/W2007294454","https://openalex.org/W2007320632","https://openalex.org/W2007330950","https://openalex.org/W2007645428","https://openalex.org/W2007965216","https://openalex.org/W2008876188","https://openalex.org/W2010731810","https://openalex.org/W2013177736","https://openalex.org/W2014180730","https://openalex.org/W2014784604","https://openalex.org/W2014851123","https://openalex.org/W2015033303","https://openalex.org/W2018815671","https://openalex.org/W2020648460","https://openalex.org/W2021858086","https://openalex.org/W2022750217","https://openalex.org/W2024393365","https://openalex.org/W2024896479","https://openalex.org/W2024986782","https://openalex.org/W2027998136","https://openalex.org/W2028575503","https://openalex.org/W2028855217","https://openalex.org/W2029967055","https://openalex.org/W2030438343","https://openalex.org/W2031445070","https://openalex.org/W2031515601","https://openalex.org/W2033644083","https://openalex.org/W2033780408","https://openalex.org/W2033858209","https://openalex.org/W2034086174","https://openalex.org/W2035108339","https://openalex.org/W2037603869","https://openalex.org/W2038192583","https://openalex.org/W2040000255","https://openalex.org/W2041888873","https://openalex.org/W2042476232","https://openalex.org/W2044629144","https://openalex.org/W2045345895","https://openalex.org/W2046004615","https://openalex.org/W2046475516","https://openalex.org/W2047109668","https://openalex.org/W2047512989","https://openalex.org/W2048543877","https://openalex.org/W2049290498","https://openalex.org/W2051521078","https://openalex.org/W2051921599","https://openalex.org/W2052128224","https://openalex.org/W2053330560","https://openalex.org/W2053809643","https://openalex.org/W2054462605","https://openalex.org/W2054475515","https://openalex.org/W2058520514","https://openalex.org/W2059924540","https://openalex.org/W2059930169","https://openalex.org/W2063662218","https://openalex.org/W2063887940","https://openalex.org/W2065034442","https://openalex.org/W2066188492","https://openalex.org/W2067991743","https://openalex.org/W2069563551","https://openalex.org/W2069623000","https://openalex.org/W2070264051","https://openalex.org/W2071221350","https://openalex.org/W2071703422","https://openalex.org/W2071794599","https://openalex.org/W2072310727","https://openalex.org/W2072537336","https://openalex.org/W2072719128","https://openalex.org/W2074142746","https://openalex.org/W2075290453","https://openalex.org/W2075989491","https://openalex.org/W2076384379","https://openalex.org/W2079378968","https://openalex.org/W2080432415","https://openalex.org/W2081193762","https://openalex.org/W2081609995","https://openalex.org/W2082001748","https://openalex.org/W2083553869","https://openalex.org/W2087693277","https://openalex.org/W2088043482","https://openalex.org/W2088227060","https://openalex.org/W2088264606","https://openalex.org/W2089638313","https://openalex.org/W2089982590","https://openalex.org/W2091471938","https://openalex.org/W2091811857","https://openalex.org/W2093542277","https://openalex.org/W2093965108","https://openalex.org/W2095488878","https://openalex.org/W2097733771","https://openalex.org/W2098748324","https://openalex.org/W2099486124","https://openalex.org/W2100062422","https://openalex.org/W2100065656","https://openalex.org/W2100489367","https://openalex.org/W2101489177","https://openalex.org/W2101970542","https://openalex.org/W2105695354","https://openalex.org/W2105945127","https://openalex.org/W2106169085","https://openalex.org/W2106169455","https://openalex.org/W2106829353","https://openalex.org/W2107109209","https://openalex.org/W2108206718","https://openalex.org/W2109550444","https://openalex.org/W2110156661","https://openalex.org/W2110178326","https://openalex.org/W2112238259","https://openalex.org/W2113289559","https://openalex.org/W2113370810","https://openalex.org/W2114709689","https://openalex.org/W2114941644","https://openalex.org/W2115226541","https://openalex.org/W2115783430","https://openalex.org/W2117344826","https://openalex.org/W2118537958","https://openalex.org/W2118765432","https://openalex.org/W2119129185","https://openalex.org/W2119277805","https://openalex.org/W2119818446","https://openalex.org/W2120649473","https://openalex.org/W2122625797","https://openalex.org/W2123372576","https://openalex.org/W2130065841","https://openalex.org/W2131015734","https://openalex.org/W2131809466","https://openalex.org/W2132432215","https://openalex.org/W2132494613","https://openalex.org/W2133193775","https://openalex.org/W2133592793","https://openalex.org/W2134931728","https://openalex.org/W2135152189","https://openalex.org/W2135356317","https://openalex.org/W2136215483","https://openalex.org/W2136739994","https://openalex.org/W2137283585","https://openalex.org/W2137445925","https://openalex.org/W2137474478","https://openalex.org/W2139581197","https://openalex.org/W2140313980","https://openalex.org/W2141336992","https://openalex.org/W2143596205","https://openalex.org/W2144201074","https://openalex.org/W2146217294","https://openalex.org/W2146592576","https://openalex.org/W2147821795","https://openalex.org/W2148734617","https://openalex.org/W2148823498","https://openalex.org/W2148864636","https://openalex.org/W2151668796","https://openalex.org/W2152228426","https://openalex.org/W2152886450","https://openalex.org/W2153276700","https://openalex.org/W2154584172","https://openalex.org/W2160009981","https://openalex.org/W2164649416","https://openalex.org/W2164699443","https://openalex.org/W2165008520","https://openalex.org/W2166227348","https://openalex.org/W2167198300","https://openalex.org/W2168233602","https://openalex.org/W2168275634","https://openalex.org/W2169074747","https://openalex.org/W2169166924","https://openalex.org/W2169799235","https://openalex.org/W2170164022","https://openalex.org/W2170866682","https://openalex.org/W2171182749","https://openalex.org/W2172131688","https://openalex.org/W2183014949","https://openalex.org/W2183402675","https://openalex.org/W2186114039","https://openalex.org/W2187616507","https://openalex.org/W2210726304","https://openalex.org/W2219615058","https://openalex.org/W2226773015","https://openalex.org/W2253689771","https://openalex.org/W2268280437","https://openalex.org/W2272871794","https://openalex.org/W2283677401","https://openalex.org/W2331224779","https://openalex.org/W2397817221","https://openalex.org/W2401129937","https://openalex.org/W2408204425","https://openalex.org/W2408352480","https://openalex.org/W2412605361","https://openalex.org/W2416074078","https://openalex.org/W2417609169","https://openalex.org/W2425846948","https://openalex.org/W2465624403"],"related_works":["https://openalex.org/W6986784032","https://openalex.org/W6986503013","https://openalex.org/W14013829","https://openalex.org/W7045731629","https://openalex.org/W51768127","https://openalex.org/W2111342835","https://openalex.org/W2524137535","https://openalex.org/W631740884","https://openalex.org/W7008282628","https://openalex.org/W2318524791"],"abstract_inverted_index":{"La":[0],"contractilit\u00e9":[1,69],"r\u00e9gionale":[2],"du":[3,98],"myocarde":[4],"est":[5,15,35,45,82],"alt\u00e9r\u00e9e":[6],"au":[7],"cours":[8],"de":[9,26,86,92,100,107,114],"la":[10,36,52,60,101],"sid\u00e9ration":[11],":":[12],"l'\u00e9paississement":[13,33,64,77],"systolique":[14],"r\u00e9duit":[16,58,76],"et":[17,41],"un":[18,24],"\u00e9paississement":[19],"postsystolique":[20,34,65],"paradoxal":[21],"appara\u00eet.":[22],"Sur":[23],"mod\u00e8le":[25],"chien":[27],"\u00e9veill\u00e9,":[28],"nous":[29],"avons":[30],"d\u00e9montr\u00e9":[31],"que":[32,42],"r\u00e9sultante":[37],"d'une":[38,84],"asynchronie":[39],"ventriculaire":[40],"ctte":[43],"anomalie":[44],"corrig\u00e9e":[46],"par":[47],"le":[48,73,112],"pr\u00e9conditionnement":[49,74],"tardif":[50,75],"ou":[51],"cardioprotection":[53],"pharmacologique.":[54],"Ainsi,":[55],"l'ivabradine":[56],"qui":[57],"s\u00e9lectivement":[59],"fr\u00e9quence":[61],"cardiaque,":[62],"convertit":[63],"inefficace":[66],"en":[67],"une":[68,90,95],"\u00e9jectionnelle.":[70],"De":[71],"m\u00eame,":[72],"postsystolique.":[78],"Cette":[79],"adaptation":[80],"contractile":[81],"concomitante":[83],"modification":[85],"l'hom\u00e9ostasie":[87],"calcique":[88],"via":[89],"\u00e9l\u00e9vation":[91],"FKBP":[93],"12.6,":[94],"prot\u00e9ine":[96],"r\u00e9gulatrice":[97],"r\u00e9cepteur":[99],"ryanodine.":[102],"Ces":[103],"r\u00e9sultats":[104],"permettent":[105],"d'identifier":[106],"nouvelles":[108],"cibles":[109],"pharmacologiques":[110],"pour":[111],"d\u00e9veloppement":[113],"strat\u00e9gies":[115],"protectrices":[116],"contre":[117],"les":[118],"l\u00e9sions":[119],"d'isch\u00e9mie/reperfusion.":[120]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}