{"id":"https://openalex.org/W58744354","doi":"https://doi.org/10.1016/s0021-9258(17)31821-5","title":"Regulation of parathyroid hormone-related protein (PTHrP) gene expression. Sp1 binds through an inverted CACCC motif and regulates promoter activity in cooperation with Ets1.","display_name":"Regulation of parathyroid hormone-related protein (PTHrP) gene expression. Sp1 binds through an inverted CACCC motif and regulates promoter activity in cooperation with Ets1.","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W58744354","doi":"https://doi.org/10.1016/s0021-9258(17)31821-5","mag":"58744354","pmid":"https://pubmed.ncbi.nlm.nih.gov/8063775"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)31821-5","doi":"https://doi.org/10.1016/s0021-9258(17)31821-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31821-5","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31821-5","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)31821-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109956734","display_name":"J Dittmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"J. Dittmer","raw_affiliation_strings":["From the Laboratory of Molecular Virology , National Cancer Institute , National Znstitutes of Health , Bethesda , Maryland 20892 and Unstitut Curie ,","HematologylOncology, Ann Arbor, MI 48109","Centre Universitaire, 91405 Orsay Cedex, France","From the Laboratory of Molecular Virology, National Cancer Institute, National Znstitutes of Health, Bethesda, Maryland 20892 and","University of Michigan Medical Center, Division","Unstitut Curie, Section de Biologie, Bdtiment 110,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory of Molecular Virology , National Cancer Institute , National Znstitutes of Health , Bethesda , Maryland 20892 and Unstitut Curie ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"HematologylOncology, Ann Arbor, MI 48109","institution_ids":[]},{"raw_affiliation_string":"Centre Universitaire, 91405 Orsay Cedex, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratory of Molecular Virology, National Cancer Institute, National Znstitutes of Health, Bethesda, Maryland 20892 and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"University of Michigan Medical Center, Division","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Unstitut Curie, Section de Biologie, Bdtiment 110,","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046369466","display_name":"Anne G\u00e9gonne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. G\u00e9gonne","raw_affiliation_strings":["Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001144056","display_name":"Scott D. Gitlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"S.D. Gitlin","raw_affiliation_strings":["Centre Universitaire, 91405 Orsay Cedex, France","From the Laboratory of Molecular Virology, National Cancer Institute, National Znstitutes of Health, Bethesda, Maryland 20892 and","HematologylOncology, Ann Arbor, MI 48109","University of Michigan Medical Center, Division","Unstitut Curie, Section de Biologie, Bdtiment 110,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Universitaire, 91405 Orsay Cedex, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratory of Molecular Virology, National Cancer Institute, National Znstitutes of Health, Bethesda, Maryland 20892 and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"HematologylOncology, Ann Arbor, MI 48109","institution_ids":[]},{"raw_affiliation_string":"University of Michigan Medical Center, Division","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Unstitut Curie, Section de Biologie, Bdtiment 110,","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105836137","display_name":"Jacques Ghysdael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"J. Ghysdael","raw_affiliation_strings":["Centre Universitaire, 91405 Orsay Cedex, France","From the Laboratory of Molecular Virology, National Cancer Institute, National Znstitutes of Health, Bethesda, Maryland 20892 and","HematologylOncology, Ann Arbor, MI 48109","University of Michigan Medical Center, Division","Unstitut Curie, Section de Biologie, Bdtiment 110,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Universitaire, 91405 Orsay Cedex, France","institution_ids":[]},{"raw_affiliation_string":"From the Laboratory of Molecular Virology, National Cancer Institute, National Znstitutes of Health, Bethesda, Maryland 20892 and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"HematologylOncology, Ann Arbor, MI 48109","institution_ids":[]},{"raw_affiliation_string":"University of Michigan Medical Center, Division","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Unstitut Curie, Section de Biologie, Bdtiment 110,","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109269727","display_name":"John N Brady","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.N. Brady","raw_affiliation_strings":["Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.5303,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.90101924,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"269","issue":"34","first_page":"21428","last_page":"21434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parathyroid-hormone-related-protein","display_name":"parathyroid hormone-related protein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.7990000247955322},{"id":"https://openalex.org/keywords/ets1","display_name":"ETS1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/transcription-factor-cooperation","display_name":"transcription factor cooperation","score":0.5450000166893005},{"id":"https://openalex.org/keywords/ternary-transcription-complex","display_name":"ternary transcription complex","score":0.621999979019165},{"id":"https://openalex.org/keywords/humoral-hypercalcemia-of-malignancy","display_name":"humoral hypercalcemia of malignancy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adult-t-cell-leukemia-lymphoma","display_name":"adult T-cell leukemia/lymphoma","score":0.6949999928474426},{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.6140000224113464},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2780538058","wikidata":"https://www.wikidata.org/wiki/Q17917642","display_name":"ETS1","level":4,"score":0.8233998417854309},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.4877210557460785},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45626330375671387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4502975344657898},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4472784996032715},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4226265847682953},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42010024189949036},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.41814762353897095},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.4105723202228546},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36976122856140137},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.366097629070282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3526536226272583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27738121151924133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23189711570739746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10700556635856628},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015682","descriptor_name":"Retroviridae Proteins, Oncogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044162","descriptor_name":"Parathyroid Hormone-Related Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)31821-5","doi":"https://doi.org/10.1016/s0021-9258(17)31821-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31821-5","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31821-5","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8063775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8063775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)31821-5","doi":"https://doi.org/10.1016/s0021-9258(17)31821-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)31821-5","pdf_url":"https://doi.org/10.1016/s0021-9258(17)31821-5","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W58744354.pdf","grobid_xml":"https://content.openalex.org/works/W58744354.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W34426497","https://openalex.org/W99079292","https://openalex.org/W278903429","https://openalex.org/W287652432","https://openalex.org/W1485888391","https://openalex.org/W1487197384","https://openalex.org/W1488783754","https://openalex.org/W1507020270","https://openalex.org/W1517070102","https://openalex.org/W1534194237","https://openalex.org/W1537591711","https://openalex.org/W1547769073","https://openalex.org/W1552879000","https://openalex.org/W1566820762","https://openalex.org/W1591908767","https://openalex.org/W1595268720","https://openalex.org/W1630990577","https://openalex.org/W1784147400","https://openalex.org/W1824191488","https://openalex.org/W1892064464","https://openalex.org/W1935682792","https://openalex.org/W1968093456","https://openalex.org/W1976243900","https://openalex.org/W1982705253","https://openalex.org/W1985452373","https://openalex.org/W1986065908","https://openalex.org/W1986941949","https://openalex.org/W1991041516","https://openalex.org/W1994762862","https://openalex.org/W1998973642","https://openalex.org/W1999300597","https://openalex.org/W2001067325","https://openalex.org/W2006784180","https://openalex.org/W2008361272","https://openalex.org/W2016973558","https://openalex.org/W2017211434","https://openalex.org/W2036753536","https://openalex.org/W2055549772","https://openalex.org/W2056356586","https://openalex.org/W2081247969","https://openalex.org/W2086652233","https://openalex.org/W2105804882","https://openalex.org/W2118446959","https://openalex.org/W2127831759","https://openalex.org/W2130258789","https://openalex.org/W2131606860","https://openalex.org/W2132958485","https://openalex.org/W2144206181","https://openalex.org/W2146886804","https://openalex.org/W2169578753","https://openalex.org/W2293303528","https://openalex.org/W2398007806","https://openalex.org/W2418013090"],"related_works":["https://openalex.org/W1517070102","https://openalex.org/W2055115648","https://openalex.org/W2161204967","https://openalex.org/W2082277569","https://openalex.org/W2079458747","https://openalex.org/W1977031433","https://openalex.org/W2076592311","https://openalex.org/W1986927024","https://openalex.org/W1981197836","https://openalex.org/W2047707350"],"abstract_inverted_index":{"W":[0],"e":[1,204],"have":[2,305],"previously":[3],"shown":[4],"that":[5,75,83,102,121,168,192,209],"mutations":[6,59],"in":[7,35,56,60,91,255],"the":[8,13,28,61,78,105,126,129,133,136,142,160,163,177,201,233,278,287],"GGAA":[9],"core":[10],"motif":[11,41,63],"of":[12,20,27,53,131,135,149,180,236,265,290],"Etsl":[14,164,171,182,198,210],"binding":[15,165],"site,":[16,166],"EBSI,":[17,21,38],"or":[18],"deletion":[19],"reduced":[22],"basal":[23,51],"and":[24,45,110,115,162,170,183,211,258,263],"Tax,":[25],"transactivation":[26],"PTHrP":[29,143,178,202,216,266,300],"P2":[30,217],"promoter.Here":[31],"we":[32,81],"demonstrate":[33],"that,":[34],"addition":[36,295],"to":[37,71,77,98,104,199,286,296,304],"a":[39,99,173,228],"CACCC-like":[40],"located":[42],"between":[43,108],"-53":[44],"-58":[46],"is":[47,250],"required":[48],"for":[49],"full":[50],"activity":[52,66,243],"this":[54,150],"promoter":[55,65,218],"Jurkat":[57],"T-cells.Site-specific":[58],"CACCC":[62,79,127],"decreased":[64],"approximately":[67],"5-fold.In":[68],"an":[69,155,181],"effort":[70],"identify":[72],"transcription":[73],"factors":[74],"bind":[76,97],"element,":[80],"found":[82],"purified":[84],"human":[85,279],"Spl,":[86],"as":[87,89,227,307,309],"well":[88,308],"Spl":[90,122,161,169,184,193,212],"HeLa":[92],"nuclear":[93],"extract,":[94],"can":[95,194,213],"specifically":[96,123],"DNA":[100,144],"probe":[101],"corresponds":[103],"PTHrP-specific":[106],"sequence":[107],"-94":[109],"-34.Gel":[111],"shift":[112,139,152],"competition":[113],"studies":[114],"DNase":[116],"I":[117,146,283],"footprinting":[118],"analyses":[119],"revealed":[120],"interacts":[124],"with":[125,141,176,197,232],"motif.In":[128],"presence":[130],"Etsl,":[132],"mobility":[134],"Spl-specific":[137],"gel":[138,151],"complex":[140,153,175],"decreased.DNase":[145],"footprint":[147,157],"analysis":[148],"showed":[154],"extended":[156],"over":[158],"both":[159],"demonstrating":[167],"form":[172],"ternary":[174],"DNA.Cotransfection":[179],"expression":[185],"vector":[186],"into":[187],"Drosophila":[188],"Schneider":[189],"cells":[190,275],"demonstrated":[191],"functionally":[195],"cooperate":[196],"transactivate":[200],"promoter.W":[203],"conclude":[205],"from":[206],"these":[207],"data":[208],"cooperatively":[214],"regulate":[215],"activity.The":[219],"parathyroid":[220],"hormone-related":[221],"protein":[222],"(PTHrP)'":[223],"was":[224],"originally":[225],"identified":[226],"humoral":[229,234,288],"factor":[230],"associated":[231],"hypercalcemia":[235,289],"malignancy":[237,291],"(1,":[238,292],"2":[239],"j.PTHrP":[240],"has":[241,301],"calcium-mobilizing":[242],"by":[244,267,277],"mimicking":[245],"PTH":[246],"action":[247],"(3,":[248],"4).It":[249],"expressed":[251],"at":[252],"low":[253],"levels":[254],"normal":[256],"fetal":[257],"adult":[259,271],"tissues":[260],"(5,":[261],"6).Overexpression":[262],"secretion":[264],"tumor":[268],"cells,":[269],"like":[270],"T-cell":[272,280],"leukemia":[273],"(ATL)":[274],"transformed":[276],"lymphotropic":[281],"virus":[282],"(HTLV-I),":[284],"leads":[285],"2,":[293],"7).In":[294],"its":[297],"PTH-like":[298],"activity,":[299],"been":[302],"reported":[303],"growth-stimulating":[306],"growth-inhibiting":[310],"properties":[311],"(6,":[312],"8-13).":[313]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}