{"id":"https://openalex.org/W58740590","doi":null,"title":"Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers.","display_name":"Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers.","publication_year":2010,"publication_date":"2010-06-12","ids":{"openalex":"https://openalex.org/W58740590","mag":"58740590","pmid":"https://pubmed.ncbi.nlm.nih.gov/20606733","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2897104"},"language":"en","primary_location":{"id":"pmid:20606733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20606733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2897104/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102891260","display_name":"Rodney E. Shackelford","orcid":"https://orcid.org/0000-0002-1129-5161","observed_orcids":["https://orcid.org/0000-0002-1129-5161"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodney E Shackelford","raw_affiliation_strings":["Department of Pathology and Cell Biology, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022728544","display_name":"Marilyn M. Bui","orcid":"https://orcid.org/0000-0003-4963-2255","observed_orcids":["https://orcid.org/0000-0003-4963-2255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marilyn M Bui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076324164","display_name":"Domenico Coppola","orcid":"https://orcid.org/0000-0001-9090-1205","observed_orcids":["https://orcid.org/0000-0001-9090-1205","https://orcid.org/0009-0008-3540-2014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Domenico Coppola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113955638","display_name":"Ardeshir Hakam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ardeshir Hakam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5493,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.95740957,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"5","first_page":"522","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/visfatin","display_name":"visfatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/serous-ovarian-cancer","display_name":"serous ovarian cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nad-biosynthesis","display_name":"NAD biosynthesis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/stat3-activation","display_name":"STAT3 activation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nampt-inhibitors","display_name":"NAMPT inhibitors","score":0.7319999933242798},{"id":"https://openalex.org/keywords/ovarian-cancer-pathogenesis","display_name":"ovarian cancer pathogenesis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2780391879","wikidata":"https://www.wikidata.org/wiki/Q18035058","display_name":"Nicotinamide phosphoribosyltransferase","level":4,"score":0.9545717239379883},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7017382383346558},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.5371383428573608},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.49909377098083496},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.440212607383728},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.43514424562454224},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.42909783124923706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41850683093070984},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.4158358573913574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39496371150016785},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3533499836921692},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29654818773269653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1125478446483612},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09370705485343933}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018284","descriptor_name":"Cystadenocarcinoma, Serous","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054409","descriptor_name":"Nicotinamide Phosphoribosyltransferase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:20606733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20606733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2897104","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2897104/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:58740590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20606733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2897104","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2897104/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1554638747","https://openalex.org/W1977369158","https://openalex.org/W1980494624","https://openalex.org/W1986272623","https://openalex.org/W1992913613","https://openalex.org/W1994099917","https://openalex.org/W2001560286","https://openalex.org/W2006173503","https://openalex.org/W2016527093","https://openalex.org/W2024282024","https://openalex.org/W2044227662","https://openalex.org/W2045442669","https://openalex.org/W2046898584","https://openalex.org/W2074343204","https://openalex.org/W2089662123","https://openalex.org/W2090513105","https://openalex.org/W2092950801","https://openalex.org/W2098050793","https://openalex.org/W2108536847","https://openalex.org/W2125933228","https://openalex.org/W2125997801","https://openalex.org/W2129222266","https://openalex.org/W2133273912","https://openalex.org/W2163820705","https://openalex.org/W2168491902","https://openalex.org/W2171892286","https://openalex.org/W2404274249","https://openalex.org/W7074201630"],"related_works":["https://openalex.org/W2381042439","https://openalex.org/W7223105308","https://openalex.org/W3015927894","https://openalex.org/W2108587241","https://openalex.org/W2950746678","https://openalex.org/W2616286706","https://openalex.org/W2406277694","https://openalex.org/W4251460713","https://openalex.org/W2973232271","https://openalex.org/W2782695319"],"abstract_inverted_index":{"Nicotinamide":[0],"phosphoribosyltransferase":[1],"(Nampt)":[2],"catalyzes":[3],"the":[4,87,136,140,153,160,171],"rate-limiting":[5],"step":[6],"of":[7,61,99,106,135,155,159,162,176,192],"nicotinamide":[8],"adenine":[9],"dinucleotide":[10],"(NAD(+))":[11],"synthesis":[12],"and":[13,22,24,35,41,86,103,173],"is":[14,43,67,117,139,185],"required":[15],"for":[16,203],"cell":[17,33],"growth,":[18],"survival,":[19],"DNA":[20],"replication":[21],"repair,":[23],"angiogenesis.":[25],"Nampt":[26,65,74,94,114,144,163,183,193,204],"expression":[27,30,66,95,116],"increases":[28,36],"gene":[29],"which":[31,148],"promotes":[32],"survival":[34],"SirT1":[37],"activity,":[38],"promoting":[39],"angiogenesis,":[40],"it":[42],"increased":[44,68,119],"in":[45,80,96,120,146,165,187,195,200],"several":[46],"human":[47],"malignancies.":[48],"Recently,":[49],"others":[50],"have":[51],"shown":[52],"that":[53,73,113],"ovarian":[54,101,107,126],"serous":[55,108],"adenocarcinomas":[56],"(OSAs)":[57],"express":[58],"high":[59],"levels":[60],"activated":[62],"Stat3.":[63],"Since":[64],"by":[69],"Stat3,":[70],"we":[71,92],"hypothesized":[72],"protein":[75,115],"might":[76],"be":[77,198],"highly":[78],"expressed":[79],"OSAs.":[81],"Using":[82],"tissue":[83,102,127],"microarray":[84],"(TMA)":[85],"avidin-biotin":[88],"complex":[89],"immunohistochemical":[90],"technique":[91],"examined":[93],"47":[97],"samples":[98,105],"benign":[100,125,129],"49":[104],"adenoacarcinomas.":[109],"Our":[110],"data":[111],"show":[112],"significantly":[118],"OSAs":[121],"as":[122],"compared":[123],"to":[124],"(0.49+/-0.12":[128],"vs.":[130],"4.78+/-0.46":[131],"malignant;":[132],"+/-standard":[133],"error":[134],"mean).":[137],"This":[138],"first":[141],"report":[142],"demonstrating":[143],"overexpression":[145,194],"OSA,":[147],"may":[149,167,197],"shed":[150,168],"light":[151,169],"on":[152,170],"pathogenesis":[154],"OSA.":[156,177],"Further":[157],"studies":[158,191],"role":[161],"overexpresion":[164],"OSA":[166,196],"prognosis":[172],"clinical":[174,188],"course":[175],"Last,":[178],"since":[179],"an":[180],"effective":[181],"pharmacologic":[182],"inhibitor":[184,205],"currently":[186],"use,":[189],"further":[190],"used":[199],"selecting":[201],"patients":[202],"therapy.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
